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Npy
Gene Detail
Symbol

Name
ID
Npy
neuropeptide Y
MGI:97374
STS
Synonyms
0710005A05Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 6
24.04 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr6:49822710-49829507 bp, + strand
From VEGA annotation of GRCm38

  6798 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:697  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NPY
Gene Tree: Npy

Human
homologs
NPY, neuropeptide Y
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 4852
neXtProt AC: NX_P01303

Human Synonyms: PYY4

Human Chr (Location): 7p15.1; chr7:24284188-24291865 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from APF )
 
Mice homozygous for a null allele exhibit sporadic mild seizures and increased susceptibility to PTZ-induced seizures. Mice homozygous for a different null allele show hypoactivity and reduced exploratory behavior, an increased anxiety-related response in males, and increased defecation in females.
 
Interactions
Npy interacts with 60 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process cell-cell signaling, feeding behavior, ...
Component cytoplasm, extracellular region, ...
Function G-protein coupled receptor binding, hormone activity, ...
External Resources: FuncBase
Expression
Literature Summary: (118 records)
Data Summary: Results (274)    Tissues (204)    Images (57)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 12
RNA in situ 255
RT-PCR 7
cDNA source data(14)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase npy ; ZFIN npy    NEW 
Molecular
reagents
All nucleic(23) Genomic(1) cDNA(16) Primer pair(5) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000034262 (Evidence)
Ensembl Gene Model ENSMUSG00000029819 (Evidence)
Entrez Gene 109648 (Evidence)
UniGene 154796
DFCI TC1583455
DoTS DT.526623
NIA Mouse Gene Index U006842
Consensus CDS Project CCDS39488.1
International Mouse Phenotyping Consortium Status Npy
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034262 VEGA Gene Model | MGI Sequence Detail 6798 C57BL/6J ±  kb
transcript OTTMUST00000087064 VEGA | MGI Sequence Detail 566 Not Applicable 
polypeptide OTTMUSP00000047208 VEGA | MGI Sequence Detail 97 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(2) UniProt(1)
Polymorphisms
All PCR and RFLP(4) : PCR(2) RFLP(2) SNPs within 2kb(122 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001955 Pancreatic hormone-like
InterPro IPR020392 Pancreatic hormone-like, conserved site
Protein Ontology PR:000011387 neuropeptide Y
References
(Earliest) J:14597 Allen JM, et al., Ontogeny of a novel peptide, neuropeptide Y (NPY) in rat brain. Brain Res. 1984 Jun 11;303(1):197-200
(Latest) J:220524 Pehrson JG, et al., Mice without MacroH2A Histone Variants. Mol Cell Biol. 2014;34(24):4523-33
All references(259)
Other
accession IDs
MGD-MRK-12928, MGI:1915648

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory