Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NPR3
  • Mouse genes Npr3
  • Rat genes Npr3
  • Zfish genes npr3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Npr3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0031404	chloride ion binding	NPR3	IDA		Human	PMID:16870210
Molecular Function	GO:0008528	G protein-coupled peptide receptor activity	Npr3	IDA		Rat	PMID:9843699|RGD:8554308
Molecular Function	GO:0042562	hormone binding	NPR3	IPI	UniProtKB:P01160|UniProtKB:P16860|UniProtKB:P23582	Human	PMID:16870210
Molecular Function	GO:0042802	identical protein binding	Npr3	IPI	RGD:3196	Rat	PMID:8702617|RGD:1601497
Molecular Function	GO:0016941	natriuretic peptide receptor activity	NPR3	IDA		Human	PMID:1660465
Molecular Function	GO:0016941	natriuretic peptide receptor activity	Npr3	IMP		Rat	PMID:15337698|RGD:1580149
Molecular Function	GO:0016941	natriuretic peptide receptor activity	Npr3	IMP		Rat	PMID:7911802|RGD:729390
Molecular Function	GO:0016941	natriuretic peptide receptor activity	Npr3	IDA		Rat	PMID:9843699|RGD:8554308
Molecular Function	GO:0042277	peptide binding	NPR3	IPI	UniProtKB:P01160|UniProtKB:P16860|UniProtKB:P23582	Human	PMID:16870210
Molecular Function	GO:0017046	peptide hormone binding	NPR3	IPI	UniProtKB:P01160	Human	PMID:1660465
Molecular Function	GO:0017046	peptide hormone binding	NPR3	IPI	UniProtKB:P16860	Human	PMID:1660465
Molecular Function	GO:0017046	peptide hormone binding	NPR3	IPI	UniProtKB:P23582	Human	PMID:1660465
Molecular Function	GO:0017046	peptide hormone binding	Npr3	IDA		Rat	PMID:8702617|RGD:1601497
Molecular Function	GO:0017046	peptide hormone binding	Npr3	IDA		Rat	PMID:9843699|RGD:8554308
Molecular Function	GO:0005515	protein binding	NPR3	IPI	UniProtKB:P01160,UniProtKB:P17342	Human	PMID:16870210
Molecular Function	GO:0005515	protein binding	NPR3	IPI	UniProtKB:P16860,UniProtKB:P17342	Human	PMID:16870210
Molecular Function	GO:0005515	protein binding	NPR3	IPI	UniProtKB:P17342,UniProtKB:P23582	Human	PMID:16870210
Molecular Function	GO:0042803	protein homodimerization activity	NPR3	IDA		Human	PMID:16870210
Cellular Component	GO:0070062	extracellular exosome	NPR3	HDA		Human	PMID:23533145
Cellular Component	GO:0016020	membrane	Npr3	IDA		Rat	PMID:8702617|RGD:1601497
Cellular Component	GO:0032991	protein-containing complex	NPR3	IDA		Human	PMID:16870210
Biological Process	GO:0007193	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	Npr3	IMP		Rat	PMID:12676657|RGD:1581461
Biological Process	GO:0001525	angiogenesis	Npr3	IMP		Mouse	PMID:30586761
Biological Process	GO:0001974	blood vessel remodeling	Npr3	IMP		Mouse	PMID:30586761
Biological Process	GO:0060038	cardiac muscle cell proliferation	npr3	IMP	ZFIN:ZDB-MRPHLNO-140401-3	Zfish	PMID:24353062
Biological Process	GO:0007194	negative regulation of adenylate cyclase activity	Npr3	IDA		Rat	PMID:8702617|RGD:1601497
Biological Process	GO:0120163	negative regulation of cold-induced thermogenesis	Npr3	IMP		Mouse	MGI:MGI:5424094|PMID:22307324
Biological Process	GO:0048662	negative regulation of smooth muscle cell proliferation	Npr3	IMP		Rat	PMID:21457229|RGD:7327141
Biological Process	GO:0002158	osteoclast proliferation	Npr3	IMP		Mouse	MGI:MGI:1339924|PMID:10377427
Biological Process	GO:0030157	pancreatic juice secretion	Npr3	IMP		Rat	PMID:12829435|RGD:1581460
Biological Process	GO:0048015	phosphatidylinositol-mediated signaling	Npr3	IMP		Rat	PMID:12829435|RGD:1581460
Biological Process	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	Npr3	IMP		Rat	PMID:15044621|RGD:1581459
Biological Process	GO:0051000	positive regulation of nitric-oxide synthase activity	Npr3	IDA		Rat	PMID:9843699|RGD:8554308
Biological Process	GO:0035810	positive regulation of urine volume	Npr3	IMP		Mouse	MGI:MGI:1339924|PMID:10377427
Biological Process	GO:0008217	regulation of blood pressure	Npr3	IMP		Mouse	MGI:MGI:1339924|PMID:10377427
Biological Process	GO:0008217	regulation of blood pressure	Npr3	IMP		Rat	PMID:15337698|RGD:1580149
Biological Process	GO:0033688	regulation of osteoblast proliferation	Npr3	IMP		Mouse	MGI:MGI:1339924|PMID:10377427
Biological Process	GO:0002931	response to ischemia	Npr3	IMP		Mouse	PMID:30586761
Biological Process	GO:0001501	skeletal system development	Npr3	IMP		Mouse	MGI:MGI:1339924|PMID:10377427
Biological Process	GO:0001501	skeletal system development	Npr3	IDA		Mouse	MGI:MGI:1339924|PMID:10377427
Biological Process	GO:0042311	vasodilation	Npr3	IMP		Rat	PMID:17391657|RGD:1642299

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern