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Npr3
Gene Detail
 Symbol
Name
ID
Npr3
natriuretic peptide receptor 3
MGI:97373
Synonyms B430320C24Rik, lgj, longjohn, Nppc receptor, NPR-C
Feature Type protein coding gene
Genetic Map
Chromosome 15
5.83 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr15:11839896-11905674 bp, - strand
From NCBI annotation of GRCm38

  65779 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:699  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: natriuretic peptide receptor C
Gene Tree: Npr3

Human
homologs
Human Homolog NPR3, natriuretic peptide receptor 3
NCBI Gene ID 4883
neXtProt AC  NX_P17342
Human Synonyms  ANP-C, ANPRC, ANPR-C, C5orf23, GUCY2B, NPRC, NPR-C
Human Chr (Location)  5p13.3; chr5:32710178-32791724 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Chemically induced (ENU)(2) Spontaneous(4) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous inactivation of this gene leads to partial postnatal lethality, altered blood homeostasis, reduced urine osmolality, polyuria, hypovolemia, hypotension, increased bone turnover and striking skeletal deformities. Spontaneous and ENU-induced mutations cause a skeletal-overgrowth phenotype.
 
Phenotype Images(5)
Interactions
Npr3 interacts with 422 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway, negative regulation of adenylate cyclase activity, ...
Component extracellular vesicular exosome, integral component of membrane, ...
Function G-protein coupled peptide receptor activity, hormone binding, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (314)    Tissues (127)    Images (56)
Theiler Stages: 10, 17, 18, 19, 20, 22, 23, 25, 28
Assay TypeResults
RNA in situ 302
Northern blot 12
cDNA source data(23)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(29) Genomic(2) cDNA(24) Primer pair(2) Other(1)
Microarray probesets(9)
Other database
links
Ensembl Gene ModelENSMUSG00000022206 (Evidence)
Entrez Gene18162 (Evidence)
Consensus CDS ProjectCCDS27386.1
International Mouse Knockout Project StatusNpr3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 18162 NCBI Gene Model | MGI Sequence Detail 65779 C57BL/6J ±  kb
transcript NM_008728 RefSeq | MGI Sequence Detail 6927 C57BL/6 
polypeptide P70180 UniProt | EBI | MGI Sequence Detail 536 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(15) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(415 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001828 Extracellular ligand-binding receptor
InterPro IPR001170 Natriuretic peptide receptor
Protein Ontology PR:000011379 atrial natriuretic peptide receptor 3
Graphical View of Protein Domain Structure
References (Earliest) J:34286 Levin ER, et al., Natriuretic peptides inhibit rat astroglial proliferation: mediation by C receptor. Am J Physiol. 1991 Aug;261(2 Pt 2):R453-7
(Latest) J:198125 Rajakumari S, et al., EBF2 determines and maintains brown adipocyte identity. Cell Metab. 2013 Apr 2;17(4):562-74
All references(54)
Other
accession IDs
MGD-MRK-12927, MGI:1330807, MGI:1330847, MGI:2146299, MGI:2442945

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory