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Npr3 Gene Detail
Summary
  • Symbol
    Npr3
  • Name
    natriuretic peptide receptor 3
  • Synonyms
    B430320C24Rik, lgj, longjohn, Nppc receptor, NPR-C
  • Feature Type
    protein coding gene
  • IDs
    MGI:97373
    NCBI Gene: 18162
  • Gene Overview
    MyGene.info: NPR3
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:11839896-11907287 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 5.83 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    424 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97373
protein coding gene Chr15:11839896-11907371 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021732
protein coding gene Chr15:9047703-9120446 (-)
A/J MGP_AJ_G0021692
protein coding gene Chr15:8773293-8841430 (-)
AKR/J MGP_AKRJ_G0021670
protein coding gene Chr15:8998651-9066427 (-)
BALB/cJ MGP_BALBcJ_G0021699
protein coding gene Chr15:8670534-8738726 (-)
C3H/HeJ MGP_C3HHeJ_G0021475
protein coding gene Chr15:8951126-9022707 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022138
protein coding gene Chr15:9378210-9450229 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019675
protein coding gene Chr15:8231164-8298465 (-)
CAST/EiJ MGP_CASTEiJ_G0020991
protein coding gene Chr15:9035163-9112566 (-)
CBA/J MGP_CBAJ_G0021444
protein coding gene Chr15:9651282-9733179 (-)
DBA/2J MGP_DBA2J_G0021568
protein coding gene Chr15:8629374-8695633 (-)
FVB/NJ MGP_FVBNJ_G0021546
protein coding gene Chr15:8482263-8551665 (-)
LP/J MGP_LPJ_G0021636
protein coding gene Chr15:8980724-9052732 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021571
protein coding gene Chr15:9887245-9975270 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022161
protein coding gene Chr15:8985262-9063034 (-)
PWK/PhJ MGP_PWKPhJ_G0020734
protein coding gene Chr15:8786064-8883781 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020572
protein coding gene Chr15:8939143-9013154 (-)
WSB/EiJ MGP_WSBEiJ_G0021047
protein coding gene Chr15:8981031-9062229 (-)



Homology
more
  • Human Ortholog
    NPR3, natriuretic peptide receptor 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NPR3, natriuretic peptide receptor 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ANP-C, ANPRC, ANPR-C, C5orf23, GUCY2B, NPRC, NPR-C
  • Links
    NCBI Gene ID: 4883
    neXtProt AC: NX_P17342
    UniProt: P17342

  • Chr Location
    5p13.3; chr5:32689076-32791724 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    71 phenotypes from 8 alleles in 9 genetic backgrounds
    5 images
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene leads to partial postnatal lethality, altered blood homeostasis, polyuria, hypovolemia, hypotension, increased bone turnover, skeletal deformities and altered adipose morphology. Spontaneous and ENU-induced mutations cause a skeletal-overgrowth phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022206 Ensembl Gene Model | MGI Sequence Detail 67392 C57BL/6J ±  kb
    transcript ENSMUST00000066529 Ensembl | MGI Sequence Detail 6892 Not Applicable  
    polypeptide ENSMUSP00000066737 Ensembl | MGI Sequence Detail 536 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 30
      Genomic 2
      cDNA 25
      Primer pair 2
      Other 1

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGD-MRK-12927, MGI:1330807, MGI:1330847, MGI:2146299, MGI:2442945
    References
    more
    • Summaries
      All 69
      Developmental Gene Expression 14
      Gene Ontology 6
      Phenotypes 17
    • Earliest
      J:34286 Levin ER, et al., Natriuretic peptides inhibit rat astroglial proliferation: mediation by C receptor. Am J Physiol. 1991 Aug;261(2 Pt 2):R453-7
    • Latest
      J:260362 Daigle TL, et al., A suite of transgenic driver and reporter mouse lines with enhanced brain cell type targeting and functionality. Cell. 2018 Jul 12;174(2):465-480.e22

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory