Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NPLOC4
  • Mouse genes Nploc4
  • Rat genes Nploc4
  • Zfish genes nploc4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nploc4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0051117	ATPase binding	Nploc4	IPI	UniProtKB:Q01853	Rat	PMID:10811609|RGD:633500
Molecular Function	GO:0036435	K48-linked polyubiquitin modification-dependent protein binding	Nploc4	IDA		Rat	PMID:12847084|RGD:10047330
Molecular Function	GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	Nploc4	IDA		Rat	PMID:12847084|RGD:10047330
Molecular Function	GO:0005515	protein binding	NPLOC4	IPI	UniProtKB:Q92890	Human	PMID:11574150
Molecular Function	GO:0005515	protein binding	NPLOC4	IPI	UniProtKB:P55072	Human	PMID:18775313
Molecular Function	GO:0005515	protein binding	NPLOC4	IPI	UniProtKB:Q92890	Human	PMID:18775313
Molecular Function	GO:0005515	protein binding	NPLOC4	IPI	UniProtKB:P55072	Human	PMID:20414249
Molecular Function	GO:0005515	protein binding	NPLOC4	IPI	UniProtKB:Q92890	Human	PMID:20414249
Molecular Function	GO:0005515	protein binding	NPLOC4	IPI	UniProtKB:P55072	Human	PMID:21645854
Molecular Function	GO:0005515	protein binding	NPLOC4	IPI	UniProtKB:Q92890	Human	PMID:21645854
Molecular Function	GO:0005515	protein binding	NPLOC4	IPI	UniProtKB:Q4G0F5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	NPLOC4	IPI	UniProtKB:Q92890	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	NPLOC4	IPI	UniProtKB:P37173	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	NPLOC4	IPI	UniProtKB:P55072	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Nploc4	IPI	RGD:619822	Rat	PMID:10811609|RGD:633500
Molecular Function	GO:0005515	protein binding	Nploc4	IPI	RGD:732949	Rat	PMID:10811609|RGD:633500
Molecular Function	GO:0005515	protein binding	Nploc4	IPI	UniProtKB:P70362	Rat	PMID:10811609|RGD:633500
Molecular Function	GO:0005515	protein binding	Nploc4	IPI	UniProtKB:Q01853	Rat	PMID:10811609|RGD:633500
Molecular Function	GO:0005515	protein binding	Nploc4	IPI	UniProtKB:Q9ES53	Rat	PMID:10811609|RGD:633500
Molecular Function	GO:0005515	protein binding	Nploc4	IPI	UniProtKB:P70362	Rat	PMID:17202270|RGD:13432310
Molecular Function	GO:0005515	protein binding	Nploc4	IPI	UniProtKB:Q01853	Rat	PMID:17202270|RGD:13432310
Molecular Function	GO:0005515	protein binding	Nploc4	IPI	UniProtKB:P70362	Rat	PMID:22232657|RGD:13432281
Molecular Function	GO:0005515	protein binding	Nploc4	IPI	UniProtKB:Q01853	Rat	PMID:22232657|RGD:13432281
Molecular Function	GO:0044877	protein-containing complex binding	Nploc4	IPI	RGD:621595|RGD:619822	Rat	PMID:10811609|RGD:633500
Molecular Function	GO:0043130	ubiquitin binding	Nploc4	IDA		Rat	PMID:18775313|RGD:8554384
Molecular Function	GO:0031625	ubiquitin protein ligase binding	Nploc4	IDA		Rat	PMID:18775313|RGD:8554384
Cellular Component	GO:0005829	cytosol	Nploc4	IDA		Rat	PMID:10811609|RGD:633500
Cellular Component	GO:0005634	nucleus	NPLOC4	HDA		Human	PMID:21630459
Cellular Component	GO:0005634	nucleus	Nploc4	IDA		Rat	PMID:10811609|RGD:633500
Cellular Component	GO:0036501	UFD1-NPL4 complex	NPLOC4	IPI	UniProtKB:Q92890	Human	PMID:11574150
Cellular Component	GO:0036501	UFD1-NPL4 complex	Nploc4	IDA		Rat	PMID:10811609|RGD:633500
Cellular Component	GO:0034098	VCP-NPL4-UFD1 AAA ATPase complex	NPLOC4	IPI		Human	PMID:20414249
Cellular Component	GO:0034098	VCP-NPL4-UFD1 AAA ATPase complex	NPLOC4	IDA		Human	PMID:26471729
Cellular Component	GO:0034098	VCP-NPL4-UFD1 AAA ATPase complex	Nploc4	EXP		Mouse	MGI:MGI:5914283|PMID:22232657
Cellular Component	GO:0034098	VCP-NPL4-UFD1 AAA ATPase complex	Nploc4	EXP		Rat	PMID:22232657|RGD:13432281
Cellular Component	GO:0034098	VCP-NPL4-UFD1 AAA ATPase complex	Nploc4	IDA		Rat	PMID:10811609|RGD:633500
Cellular Component	GO:0034098	VCP-NPL4-UFD1 AAA ATPase complex	Nploc4	IDA		Rat	PMID:17000876|RGD:10047192
Cellular Component	GO:0034098	VCP-NPL4-UFD1 AAA ATPase complex	Nploc4	IDA		Rat	PMID:18775313|RGD:8554384
Biological Process	GO:0007030	Golgi organization	Nploc4	IDA		Rat	PMID:10811609|RGD:633500
Biological Process	GO:0039536	negative regulation of RIG-I signaling pathway	NPLOC4	IMP		Human	PMID:26471729
Biological Process	GO:0032480	negative regulation of type I interferon production	NPLOC4	IMP		Human	PMID:26471729
Biological Process	GO:0030970	retrograde protein transport, ER to cytosol	NPLOC4	IMP		Human	PMID:25660456
Biological Process	GO:0030970	retrograde protein transport, ER to cytosol	Nploc4	EXP		Mouse	MGI:MGI:5634892|PMID:12847084
Biological Process	GO:0030970	retrograde protein transport, ER to cytosol	Nploc4	EXP		Rat	PMID:12847084|RGD:10047330
Biological Process	GO:0030433	ubiquitin-dependent ERAD pathway	Nploc4	EXP		Mouse	MGI:MGI:5634892|PMID:12847084
Biological Process	GO:0030433	ubiquitin-dependent ERAD pathway	Nploc4	EXP		Rat	PMID:12847084|RGD:10047330
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	NPLOC4	IMP		Human	PMID:26471729

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern