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Nploc4
Gene Detail
Symbol

Name
ID
Nploc4
nuclear protein localization 4 homolog (S. cerevisiae)
MGI:2679787
Synonyms
mKIAA1499
Feature Type
protein coding gene
Genetic Map
Chromosome 11
84.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:120380370-120437708 bp, - strand
From VEGA annotation of GRCm38

  57339 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5403  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: polyubiquitin-tagged protein recognition complex, Npl4 component
Gene Tree: Nploc4

Human
homologs
Human Homolog NPLOC4, nuclear protein localization 4 homolog (S. cerevisiae)
NCBI Gene ID 55666
neXtProt AC  NX_Q8TAT6
Human Synonyms  NPL4
Human Chr (Location)  17qter; chr17:81556887-81637112 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(19) : Gene trapped(17) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Nploc4 interacts with 268 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process Golgi organization, membrane fusion
Component Cdc48p-Npl4p-Ufd1p AAA ATPase complex, cytoplasm, ...
Function metal ion binding, protein complex binding, ...
External Resources: FuncBase
Expression
cDNA source data(8)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(8) cDNA(8)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000004173 (Evidence)
Ensembl Gene ModelENSMUSG00000039703 (Evidence)
Entrez Gene217365 (Evidence)
DFCITC1652688, TC1601550, TC1575281
DoTSDT.101232245, DT.94292782, DT.531432
NIA Mouse Gene IndexU033712
PDB2PJH
Consensus CDS ProjectCCDS25732.1, CCDS56827.1
International Mouse Knockout Project StatusNploc4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004173 VEGA Gene Model | MGI Sequence Detail 57339 C57BL/6J ±  kb
transcript OTTMUST00000009470 VEGA | MGI Sequence Detail 4121 Not Applicable 
polypeptide OTTMUSP00000004607 VEGA | MGI Sequence Detail 608 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(6) UniProt(5)
Polymorphisms
SNPs within 2kb(77 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007716 NPL4, zinc-binding putative
InterPro IPR007717 Nuclear pore localisation protein NPL4
InterPro IPR024682 Nuclear pore localisation protein Npl4, ubiquitin-like domain
InterPro IPR016563 Polyubiquitin-tagged protein recognition complex, Npl4 component
InterPro IPR001876 Zinc finger, RanBP2-type
Protein Ontology PR:000011369 nuclear protein localization protein 4
References
(Earliest) J:86686 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Aug 31;10(4):167-80
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(33)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory