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Nploc4 Gene Detail
Summary
  • Symbol
    Nploc4
  • Name
    NPL4 homolog, ubiquitin recognition factor
  • Synonyms
    mKIAA1499
  • Feature Type
    protein coding gene
  • IDs
    MGI:2679787
    NCBI Gene: 217365
  • Gene Overview
    MyGene.info: NPLOC4
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:120380370-120437708 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 84.09 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    77 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2679787
protein coding gene Chr11:120379798-120437708 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019498
protein coding gene Chr11:124836730-124904117 (-)
A/J MGP_AJ_G0019466
protein coding gene Chr11:119287292-119345958 (-)
AKR/J MGP_AKRJ_G0019436
protein coding gene Chr11:122871808-122933537 (-)
BALB/cJ MGP_BALBcJ_G0019441
protein coding gene Chr11:119639968-119700071 (-)
C3H/HeJ MGP_C3HHeJ_G0019247
protein coding gene Chr11:123209140-123271057 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019889
protein coding gene Chr11:128613068-128682084 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017515
protein coding gene Chr11:116277260-116334969 (-)
CAST/EiJ MGP_CASTEiJ_G0018801
protein coding gene Chr11:124685938-124747632 (-)
CBA/J MGP_CBAJ_G0019218
protein coding gene Chr11:133649462-133717097 (-)
DBA/2J MGP_DBA2J_G0019330
protein coding gene Chr11:118656254-118714750 (-)
FVB/NJ MGP_FVBNJ_G0019322
protein coding gene Chr11:118360920-118423621 (-)
LP/J MGP_LPJ_G0019402
protein coding gene Chr11:125139392-125201603 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019355
protein coding gene Chr11:132489400-132561840 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019929
protein coding gene Chr11:123558366-123622922 (-)
PWK/PhJ MGP_PWKPhJ_G0018567
protein coding gene Chr11:120084708-120145717 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018359
protein coding gene Chr11:123321600-123380441 (-)
WSB/EiJ MGP_WSBEiJ_G0018853
protein coding gene Chr11:123548517-123610076 (-)



Homology
more
  • Human Ortholog
    NPLOC4, NPL4 homolog, ubiquitin recognition factor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NPLOC4, NPL4 homolog, ubiquitin recognition factor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NPL4
  • Links
    NCBI Gene ID: 55666
    neXtProt AC: NX_Q8TAT6
    UniProt: Q8TAT6

  • Chr Location
    17q25.3; chr17:81556885-81637153 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000039703 Ensembl Gene Model | MGI Sequence Detail 57339 C57BL/6J ±  kb
transcript ENSMUST00000044271 Ensembl | MGI Sequence Detail 4121 Not Applicable  
polypeptide ENSMUSP00000035851 Ensembl | MGI Sequence Detail 608 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 9
    cDNA 9

    Microarray probesets 3
References
more
  • Summaries
    All 31
    Gene Ontology 5
    Phenotypes 7
  • Earliest
    J:220517 Meyer HH, et al., A complex of mammalian ufd1 and npl4 links the AAA-ATPase, p97, to ubiquitin and nuclear transport pathways. EMBO J. 2000 May 15;19(10):2181-92
  • Latest
    J:236193 Shimizu S, et al., Differential Involvement of the Npl4 Zinc Finger Domains of SHARPIN and HOIL-1L in Linear Ubiquitin Chain Assembly Complex-Mediated Cell Death Protection. Mol Cell Biol. 2016 May 15;36(10):1569-83

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory