Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Nlrp6

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes NLRP6
- Mouse genes Nlrp6
- Rat genes Nlrp6
- Zfish genes nlrb5,nlrp1
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nlrp6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003725	double-stranded RNA binding	NLRP6	IDA		Human	PMID:34678144
Molecular Function	GO:0003725	double-stranded RNA binding	Nlrp6	IDA		Mouse	MGI:MGI:6833928\|PMID:34678144
Molecular Function	GO:0001530	lipopolysaccharide binding	NLRP6	IDA		Human	PMID:31932628
Molecular Function	GO:0070891	lipoteichoic acid binding	NLRP6	IDA		Human	PMID:30392956
Molecular Function	GO:0070891	lipoteichoic acid binding	NLRP6	IDA		Human	PMID:33377178
Molecular Function	GO:0070891	lipoteichoic acid binding	NLRP6	IDA		Human	PMID:34678144
Molecular Function	GO:0070891	lipoteichoic acid binding	Nlrp6	IDA		Mouse	MGI:MGI:6259277\|PMID:30392956
Molecular Function	GO:0070891	lipoteichoic acid binding	Nlrp6	IDA		Mouse	MGI:MGI:6833928\|PMID:34678144
Molecular Function	GO:0140693	molecular condensate scaffold activity	NLRP6	IDA		Human	PMID:34678144
Molecular Function	GO:0140693	molecular condensate scaffold activity	Nlrp6	IDA		Mouse	MGI:MGI:6833928\|PMID:34678144
Molecular Function	GO:0140677	molecular function activator activity	NLRP6	IDA		Human	PMID:34678144
Molecular Function	GO:0038187	pattern recognition receptor activity	NLRP6	IDA		Human	PMID:31932628
Molecular Function	GO:0038187	pattern recognition receptor activity	NLRP6	IDA		Human	PMID:33377178
Molecular Function	GO:0038187	pattern recognition receptor activity	NLRP6	IDA		Human	PMID:34678144
Molecular Function	GO:0038187	pattern recognition receptor activity	Nlrp6	IDA		Mouse	MGI:MGI:6833928\|PMID:34678144
Molecular Function	GO:0042277	peptide binding	Nlrp6	IMP		Rat	PMID:7489366\|RGD:724666
Molecular Function	GO:0005515	protein binding	Nlrp6	IPI	UniProtKB:O35286\|UniProtKB:O43143\|UniProtKB:Q7Z434-1	Mouse	MGI:MGI:5699624\|PMID:26494172
Molecular Function	GO:0035591	signaling adaptor activity	NLRP6	IDA		Human	PMID:34678144
Molecular Function	GO:0030546	signaling receptor activator activity	NLRP6	IDA		Human	PMID:30392956
Molecular Function	GO:0030546	signaling receptor activator activity	NLRP6	IDA		Human	PMID:34678144
Molecular Function	GO:0005000	vasopressin receptor activity	Nlrp6	IDA		Rat	PMID:18413781\|RGD:8554347
Cellular Component	GO:0061702	canonical inflammasome complex	Nlrp6	IDA		Mouse	PMID:30248149
Cellular Component	GO:0061702	canonical inflammasome complex	nlrp1	IPI	ZFIN:ZDB-GENE-000616-3,ZFIN:ZDB-GENE-000511-2	Zfish	PMID:30150286
Cellular Component	GO:0061702	canonical inflammasome complex	nlrp1	IPI	ZFIN:ZDB-GENE-020812-1,ZFIN:ZDB-GENE-000511-2	Zfish	PMID:30150286
Cellular Component	GO:0005737	cytoplasm	nlrb5	IDA		Zfish	PMID:24858030
Cellular Component	GO:0005829	cytosol	NLRP6	IDA		Human	PMID:31932628
Cellular Component	GO:0072558	NLRP1 inflammasome complex	nlrp1	IPI		Zfish	PMID:30150286\|ZFIN:ZDB-PUB-180829-2
Cellular Component	GO:0072558	NLRP1 inflammasome complex	nlrp1	IDA		Zfish	PMID:30150286\|ZFIN:ZDB-PUB-180829-2
Cellular Component	GO:0140738	NLRP6 inflammasome complex	NLRP6	IDA		Human	PMID:30674671
Cellular Component	GO:0140738	NLRP6 inflammasome complex	NLRP6	IDA		Human	PMID:31932628
Cellular Component	GO:0140738	NLRP6 inflammasome complex	NLRP6	IDA		Human	PMID:34678144
Cellular Component	GO:0140738	NLRP6 inflammasome complex	Nlrp6	IDA		Mouse	MGI:MGI:6833928\|PMID:34678144
Cellular Component	GO:0140738	NLRP6 inflammasome complex	Nlrp6	IDA		Mouse	MGI:MGI:6706628\|PMID:32424362
Cellular Component	GO:0043228	non-membrane-bounded organelle	NLRP6	IDA		Human	PMID:34678144
Cellular Component	GO:0043228	non-membrane-bounded organelle	Nlrp6	IDA		Mouse	MGI:MGI:6833928\|PMID:34678144
Biological Process	GO:0097202	activation of cysteine-type endopeptidase activity	Nlrp6	IMP		Mouse	PMID:30248149
Biological Process	GO:0002526	acute inflammatory response	Nlrp6	IMP		Mouse	PMID:30248149
Biological Process	GO:0002438	acute inflammatory response to antigenic stimulus	Nlrp6	IMP		Mouse	PMID:30248149
Biological Process	GO:0140374	antiviral innate immune response	NLRP6	IDA		Human	PMID:34161762
Biological Process	GO:0140374	antiviral innate immune response	Nlrp6	IDA		Mouse	MGI:MGI:6833928\|PMID:34678144
Biological Process	GO:0140374	antiviral innate immune response	Nlrp6	IMP		Mouse	MGI:MGI:5699624\|PMID:26494172
Biological Process	GO:0050830	defense response to Gram-positive bacterium	NLRP6	IDA		Human	PMID:33377178
Biological Process	GO:0050830	defense response to Gram-positive bacterium	NLRP6	IDA		Human	PMID:34678144
Biological Process	GO:0050830	defense response to Gram-positive bacterium	Nlrp6	IDA		Mouse	MGI:MGI:6259277\|PMID:30392956
Biological Process	GO:0051607	defense response to virus	NLRP6	IDA		Human	PMID:34161762
Biological Process	GO:0051607	defense response to virus	NLRP6	IDA		Human	PMID:34678144
Biological Process	GO:0051607	defense response to virus	Nlrp6	IMP		Mouse	MGI:MGI:5699624\|PMID:26494172
Biological Process	GO:0048874	host-mediated regulation of intestinal microbiota composition	Nlrp6	IMP		Mouse	MGI:MGI:5704237\|PMID:26638072
Biological Process	GO:0032611	interleukin-1 beta production	Nlrp6	IMP		Mouse	PMID:30248149
Biological Process	GO:0032621	interleukin-18 production	Nlrp6	IMP		Mouse	PMID:30248149
Biological Process	GO:0070266	necroptotic process	Nlrp6	IMP		Mouse	PMID:30248149
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	Nlrp6	IMP		Mouse	MGI:MGI:5432950\|PMID:22763455
Biological Process	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	Nlrp6	IMP	MGI:MGI:5085850	Mouse	PMID:22763455
Biological Process	GO:0050777	negative regulation of immune response	Nlrp6	IMP	MGI:MGI:5085850	Mouse	PMID:22763455
Biological Process	GO:0002862	negative regulation of inflammatory response to antigenic stimulus	Nlrp6	IMP		Mouse	MGI:MGI:5432950\|PMID:22763455
Biological Process	GO:0043409	negative regulation of MAPK cascade	Nlrp6	IMP	MGI:MGI:5085850	Mouse	PMID:22763455
Biological Process	GO:0034122	negative regulation of toll-like receptor signaling pathway	Nlrp6	IMP	MGI:MGI:5085850	Mouse	PMID:22763455
Biological Process	GO:0032689	negative regulation of type II interferon production	Nlrp6	IMP		Mouse	PMID:30248149
Biological Process	GO:0070946	neutrophil-mediated killing of gram-positive bacterium	Nlrp6	IMP		Mouse	PMID:30248149
Biological Process	GO:0140739	NLRP6 inflammasome complex assembly	NLRP6	IDA		Human	PMID:30674671
Biological Process	GO:0140739	NLRP6 inflammasome complex assembly	NLRP6	IDA		Human	PMID:31932628
Biological Process	GO:0140739	NLRP6 inflammasome complex assembly	NLRP6	IDA		Human	PMID:34678144
Biological Process	GO:0140739	NLRP6 inflammasome complex assembly	Nlrp6	IDA		Mouse	MGI:MGI:6833928\|PMID:34678144
Biological Process	GO:0140739	NLRP6 inflammasome complex assembly	Nlrp6	IDA		Mouse	MGI:MGI:6706628\|PMID:32424362
Biological Process	GO:0050729	positive regulation of inflammatory response	NLRP6	IDA		Human	PMID:33377178
Biological Process	GO:0050729	positive regulation of inflammatory response	Nlrp6	IDA		Mouse	MGI:MGI:5699624\|PMID:26494172
Biological Process	GO:2000494	positive regulation of interleukin-18-mediated signaling pathway	NLRP6	IDA		Human	PMID:33377178
Biological Process	GO:2000494	positive regulation of interleukin-18-mediated signaling pathway	NLRP6	IDA		Human	PMID:34161762
Biological Process	GO:2000494	positive regulation of interleukin-18-mediated signaling pathway	Nlrp6	IDA		Mouse	MGI:MGI:6259277\|PMID:30392956
Biological Process	GO:2000494	positive regulation of interleukin-18-mediated signaling pathway	Nlrp6	IDA		Mouse	MGI:MGI:6833928\|PMID:34678144
Biological Process	GO:2000494	positive regulation of interleukin-18-mediated signaling pathway	Nlrp6	IMP		Mouse	MGI:MGI:5704237\|PMID:26638072
Biological Process	GO:0051260	protein homooligomerization	NLRP6	IDA		Human	PMID:30674671
Biological Process	GO:0051260	protein homooligomerization	NLRP6	IDA		Human	PMID:31932628
Biological Process	GO:0051260	protein homooligomerization	NLRP6	IDA		Human	PMID:34678144
Biological Process	GO:0051260	protein homooligomerization	Nlrp6	IDA		Mouse	MGI:MGI:6833928\|PMID:34678144
Biological Process	GO:0070269	pyroptosis	Nlrp6	IDA		Mouse	MGI:MGI:6833928\|PMID:34678144
Biological Process	GO:0070269	pyroptosis	Nlrp6	IMP		Mouse	PMID:30248149
Biological Process	GO:0010506	regulation of autophagy	Nlrp6	IMP	MGI:MGI:5085850	Mouse	PMID:24581500
Biological Process	GO:0050727	regulation of inflammatory response	Nlrp6	IMP		Mouse	MGI:MGI:5285812\|PMID:21543645
Biological Process	GO:0050727	regulation of inflammatory response	Nlrp6	IMP	MGI:MGI:5085850	Mouse	PMID:23696660
Biological Process	GO:0070255	regulation of mucus secretion	Nlrp6	IMP	MGI:MGI:5085850	Mouse	PMID:24581500
Biological Process	GO:0009617	response to bacterium	Nlrp6	IMP	MGI:MGI:5085850	Mouse	PMID:24581500
Biological Process	GO:0009617	response to bacterium	Nlrp6	IMP	MGI:MGI:5085850	Mouse	PMID:23696660
Biological Process	GO:0009617	response to bacterium	Nlrp6	IMP	MGI:MGI:5085850	Mouse	PMID:23075849
Biological Process	GO:0042060	wound healing	Nlrp6	IMP	MGI:MGI:5140329	Mouse	PMID:21593405

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/07/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.