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Nlrp6
Gene Detail
Symbol

Name
ID
Nlrp6
NLR family, pyrin domain containing 6
MGI:2141990
Synonyms
Nalp6
Feature Type
protein coding gene
Genetic Map
Chromosome 7
86.14 cM, cytoband F4
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:140920902-140929192 bp, + strand
From VEGA annotation of GRCm38

  8291 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:15881  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: NLRP6
Gene Tree: Nlrp6

Human
homologs
NLRP6, NLR family, pyrin domain containing 6
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 171389
neXtProt AC: NX_P59044

Human Synonyms: AVR, CLR11.4, NALP6, NAVR, NAVR/AVR, PAN3, PYPAF5

Human Chr (Location): 11p15; chr11:278365-285388 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted allele exhibit increased susceptibility to DSS-induced colitis, decreased circulating and colonic IL18 levels, colonic crypt hyperplasia, enlarged Peyer's patches, increased IgG2c and IgA serum levels, increased leukocytes, and expanded gut bacterial phylotypes.
 
Interactions
Nlrp6 interacts with 153 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process G-protein coupled receptor signaling pathway, negative regulation of I-kappaB kinase/NF-kappaB signaling, ...
Component cytoplasm, membrane, ...
Function ATP binding, nucleotide binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (5)    Tissues (1)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 5
cDNA source data(7)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(7) cDNA(7)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000044619 (Evidence)
Ensembl Gene Model ENSMUSG00000038745 (Evidence)
Entrez Gene 101613 (Evidence)
DFCI TC1712634, TC1584804
DoTS DT.101365135, DT.101365136, DT.40173544, DT.94193894
NIA Mouse Gene Index U008940
Consensus CDS Project CCDS40178.2
International Mouse Phenotyping Consortium Status Nlrp6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000044619 VEGA Gene Model | MGI Sequence Detail 8291 C57BL/6J ±  kb
transcript OTTMUST00000117370 VEGA | MGI Sequence Detail 3178 Not Applicable 
polypeptide OTTMUSP00000065642 VEGA | MGI Sequence Detail 899 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(5) UniProt(4)
Polymorphisms
SNPs within 2kb(192 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004020 DAPIN domain
InterPro IPR011029 Death-like domain
InterPro IPR007111 NACHT nucleoside triphosphatase
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000011274 NACHT, LRR and PYD domains-containing protein 6
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:212020 Wlodarska M, et al., NLRP6 inflammasome orchestrates the colonic host-microbial interface by regulating goblet cell mucus secretion. Cell. 2014 Feb 27;156(5):1045-59
All references(41)
Other
accession IDs
MGI:2448892

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory