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Nlrp6
Gene Detail
 Symbol
Name
ID
Nlrp6
NLR family, pyrin domain containing 6
MGI:2141990
Synonyms Nalp6
Feature Type protein coding gene
Genetic Map
Chromosome 7
86.14 cM, cytoband F4
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:140920902-140929192 bp, + strand
From VEGA annotation of GRCm38

  8291 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:15881  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Nlrp6

Human
homologs
Human Homolog NLRP6, NLR family, pyrin domain containing 6
NCBI Gene ID 171389
neXtProt AC  NX_P59044
Human Synonyms  AVR, CLR11.4, NALP6, NAVR, NAVR/AVR, PAN3, PYPAF5
Human Chr (Location)  11p15; chr11:278570-285388 (+)  GRCh38
Alleles
and
phenotypes
All alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted allele exhibit increased susceptibility to DSS-induced colitis, decreased circulating and colonic IL18 levels, colonic crypt hyperplasia, enlarged Peyer's patches, increased IgG2c and IgA serum levels, increased leukocytes, and expanded gut bacterial phylotypes.
 
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process G-protein coupled receptor signaling pathway, negative regulation of I-kappaB kinase/NF-kappaB signaling, ...
Component cytoplasm, membrane, ...
Function ATP binding, nucleotide binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (5)    Tissues (1)    Images (5)
Theiler Stages: 23
Assay TypeResults
RNA in situ 5
cDNA source data(7)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(7) cDNA(7)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000044619 (Evidence)
Ensembl Gene ModelENSMUSG00000038745 (Evidence)
Entrez Gene101613 (Evidence)
DFCITC1584804, TC1712634
DoTSDT.101365135, DT.101365136, DT.40173544, DT.94193894
NIA Mouse Gene IndexU008940
Consensus CDS ProjectCCDS40178.2
International Mouse Knockout Project StatusNlrp6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000044619 VEGA Gene Model | MGI Sequence Detail 8291 C57BL/6J ±  kb
transcript OTTMUST00000117370 VEGA | MGI Sequence Detail 3178 Not Applicable 
polypeptide OTTMUSP00000065642 VEGA | MGI Sequence Detail 899 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(7) UniProt(4)
Polymorphisms SNPs within 2kb(192 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004020 DAPIN domain
InterPro IPR011029 Death-like domain
InterPro IPR007111 NACHT nucleoside triphosphatase
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000011274 NACHT, LRR and PYD domains-containing protein 6
References (Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:205949 Shah S, et al., Cutting edge: Mycobacterium tuberculosis but not nonvirulent mycobacteria inhibits IFN-beta and AIM2 inflammasome-dependent IL-1beta production via its ESX-1 secretion system. J Immunol. 2013 Oct 1;191(7):3514-8
All references(42)
Other
accession IDs
MGI:2448892

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory