Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Nlgn2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes NLGN2
- Mouse genes Nlgn2
- Rat genes Nlgn2
- Zfish genes nlgn2a,nlgn2b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nlgn2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0050839	cell adhesion molecule binding	Nlgn2	IPI	UniProtKB:Q9CS84	Mouse	MGI:MGI:5285129\|PMID:21424692
Molecular Function	GO:0042802	identical protein binding	Nlgn2	IPI	UniProtKB:Q69ZK9	Mouse	MGI:MGI:6093141\|PMID:18250328
Molecular Function	GO:0042043	neurexin family protein binding	Nlgn2	IPI	UniProtKB:E9Q7X7	Mouse	MGI:MGI:5285129\|PMID:21424692
Molecular Function	GO:0042043	neurexin family protein binding	Nlgn2	IPI	UniProtKB:Q9CS84	Mouse	MGI:MGI:5285129\|PMID:21424692
Molecular Function	GO:0005515	protein binding	Nlgn2	IPI	UniProtKB:Q5U4E0	Mouse	MGI:MGI:6201911\|PMID:29742426
Molecular Function	GO:0005515	protein binding	Nlgn2	IPI	UniProtKB:O14522	Mouse	MGI:MGI:5508578\|PMID:19816407
Molecular Function	GO:0005515	protein binding	Nlgn2	IPI	PR:Q810B9	Mouse	PMID:29107521
Molecular Function	GO:0005515	protein binding	Nlgn2	IPI	PR:Q9CS84	Mouse	PMID:29107521
Molecular Function	GO:0005515	protein binding	Nlgn2	IPI	PR:Q8BUV3	Mouse	PMID:29107521
Molecular Function	GO:0005515	protein binding	Nlgn2	IPI	RGD:69194	Rat	PMID:19755106\|RGD:9831130
Molecular Function	GO:0005515	protein binding	Nlgn2	IPI	UniProtKB:P18508,UniProtKB:P62813,UniProtKB:P63079,UniProtKB:P63138,UniProtKB:Q7TSY2	Rat	PMID:28279354\|RGD:13800541
Cellular Component	GO:0009986	cell surface	Nlgn2	IDA		Mouse	PMID:29107521
Cellular Component	GO:0009986	cell surface	Nlgn2	IDA		Rat	PMID:15797875\|RGD:8554205
Cellular Component	GO:0009986	cell surface	Nlgn2	IDA		Rat	PMID:19914352\|RGD:8554031
Cellular Component	GO:0009986	cell surface	Nlgn2	IDA		Rat	PMID:22528485\|RGD:9743981
Cellular Component	GO:0005737	cytoplasm	Nlgn2	IDA		Rat	PMID:18755801\|RGD:2314456
Cellular Component	GO:0043198	dendritic shaft	Nlgn2	IDA		Rat	PMID:22539981\|RGD:9831126
Cellular Component	GO:0098691	dopaminergic synapse	Nlgn2	IDA		Mouse	PMID:27035941
Cellular Component	GO:0060076	excitatory synapse	Nlgn2	IDA		Rat	PMID:19914352\|RGD:8554031
Cellular Component	GO:0098982	GABA-ergic synapse	Nlgn2	IDA		Mouse	PMID:29107521
Cellular Component	GO:0098982	GABA-ergic synapse	Nlgn2	IPI		Mouse	PMID:19755106
Cellular Component	GO:0098982	GABA-ergic synapse	Nlgn2	IDA		Mouse	PMID:19755106
Cellular Component	GO:0098982	GABA-ergic synapse	Nlgn2	IMP		Mouse	PMID:19755106
Cellular Component	GO:0098982	GABA-ergic synapse	Nlgn2	IMP		Mouse	PMID:15620359
Cellular Component	GO:0098982	GABA-ergic synapse	Nlgn2	IDA		Mouse	PMID:15620359
Cellular Component	GO:0098982	GABA-ergic synapse	Nlgn2	IDA		Rat	PMID:15540461\|RGD:9743978
Cellular Component	GO:0098982	GABA-ergic synapse	Nlgn2	IDA		Rat	PMID:27565350\|RGD:13702337
Cellular Component	GO:0098982	GABA-ergic synapse	Nlgn2	IMP		Rat	PMID:27565350\|RGD:13702337
Cellular Component	GO:0098690	glycinergic synapse	Nlgn2	IDA		Mouse	PMID:19755106
Cellular Component	GO:0098690	glycinergic synapse	Nlgn2	IPI		Mouse	PMID:19755106
Cellular Component	GO:0098690	glycinergic synapse	Nlgn2	IMP		Mouse	PMID:19755106
Cellular Component	GO:0060077	inhibitory synapse	Nlgn2	IDA		Rat	PMID:15540461\|RGD:9743978
Cellular Component	GO:0060077	inhibitory synapse	Nlgn2	IDA		Rat	PMID:18550748\|RGD:8554527
Cellular Component	GO:0060077	inhibitory synapse	Nlgn2	IDA		Rat	PMID:19859968\|RGD:9831128
Cellular Component	GO:0060077	inhibitory synapse	Nlgn2	IDA		Rat	PMID:19914352\|RGD:8554031
Cellular Component	GO:0005886	plasma membrane	Nlgn2	IDA		Rat	PMID:19914352\|RGD:8554031
Cellular Component	GO:0045211	postsynaptic membrane	Nlgn2	IDA		Rat	PMID:15540461\|RGD:9743978
Cellular Component	GO:0045211	postsynaptic membrane	Nlgn2	IDA		Rat	PMID:15797875\|RGD:8554205
Cellular Component	GO:0099634	postsynaptic specialization membrane	Nlgn2	IDA		Mouse	PMID:27035941
Cellular Component	GO:0099634	postsynaptic specialization membrane	Nlgn2	IDA		Rat	PMID:15540461\|RGD:9743978
Cellular Component	GO:0099634	postsynaptic specialization membrane	Nlgn2	IDA		Rat	PMID:27565350\|RGD:13702337
Cellular Component	GO:0099634	postsynaptic specialization membrane	Nlgn2	IMP		Rat	PMID:27565350\|RGD:13702337
Cellular Component	GO:0097470	ribbon synapse	Nlgn2	IDA		Rat	PMID:19859968\|RGD:9831128
Cellular Component	GO:0045202	synapse	Nlgn2	IDA		Mouse	PMID:15681343
Biological Process	GO:0007420	brain development	Nlgn2	IEP		Rat	PMID:15540461\|RGD:9743978
Biological Process	GO:0097116	gephyrin clustering involved in postsynaptic density assembly	Nlgn2	IDA		Mouse	MGI:MGI:5284797\|PMID:15620359
Biological Process	GO:0097116	gephyrin clustering involved in postsynaptic density assembly	Nlgn2	IMP		Mouse	PMID:29107521
Biological Process	GO:0097116	gephyrin clustering involved in postsynaptic density assembly	Nlgn2	IGI	MGI:MGI:2679447	Mouse	PMID:29107521
Biological Process	GO:1904862	inhibitory synapse assembly	Nlgn2	IDA		Mouse	MGI:MGI:5780536\|PMID:22960622
Biological Process	GO:1901142	insulin metabolic process	Nlgn2	IDA		Rat	PMID:22528485\|RGD:9743981
Biological Process	GO:0007630	jump response	Nlgn2	IMP		Rat	PMID:18550748\|RGD:8554527
Biological Process	GO:0035641	locomotory exploration behavior	Nlgn2	IMP		Mouse	MGI:MGI:4352827\|PMID:19016888
Biological Process	GO:0050804	modulation of chemical synaptic transmission	Nlgn2	IGI	MGI:MGI:2179435	Mouse	PMID:16982420
Biological Process	GO:0050885	neuromuscular process controlling balance	Nlgn2	IMP		Mouse	MGI:MGI:4352827\|PMID:19016888
Biological Process	GO:0007158	neuron cell-cell adhesion	Nlgn2	IDA		Rat	PMID:15797875\|RGD:8554205
Biological Process	GO:0072578	neurotransmitter-gated ion channel clustering	Nlgn2	IGI	MGI:MGI:2679447	Mouse	PMID:29107521
Biological Process	GO:0072578	neurotransmitter-gated ion channel clustering	Nlgn2	IMP		Mouse	PMID:29107521
Biological Process	GO:0072578	neurotransmitter-gated ion channel clustering	Nlgn2	IDA		Mouse	PMID:29107521
Biological Process	GO:0008284	positive regulation of cell population proliferation	Nlgn2	IDA		Rat	PMID:22528485\|RGD:9743981
Biological Process	GO:0060999	positive regulation of dendritic spine development	Nlgn2	IMP		Rat	PMID:15681343\|RGD:8553420
Biological Process	GO:2000463	positive regulation of excitatory postsynaptic potential	Nlgn2	IMP		Mouse	MGI:MGI:5284797\|PMID:15620359
Biological Process	GO:0097151	positive regulation of inhibitory postsynaptic potential	Nlgn2	IMP		Mouse	MGI:MGI:5284797\|PMID:15620359
Biological Process	GO:0097151	positive regulation of inhibitory postsynaptic potential	Nlgn2	IMP		Mouse	MGI:MGI:3803801\|PMID:17582332
Biological Process	GO:0097151	positive regulation of inhibitory postsynaptic potential	Nlgn2	IMP		Rat	PMID:18550748\|RGD:8554527
Biological Process	GO:0032024	positive regulation of insulin secretion	NLGN2	IMP		Human	PMID:22528485
Biological Process	GO:0032024	positive regulation of insulin secretion	Nlgn2	IMP		Rat	PMID:18755801\|RGD:2314456
Biological Process	GO:0032024	positive regulation of insulin secretion	Nlgn2	IDA		Rat	PMID:22528485\|RGD:9743981
Biological Process	GO:1902474	positive regulation of protein localization to synapse	NLGN2	IDA		Human	PMID:24613359
Biological Process	GO:1902474	positive regulation of protein localization to synapse	Nlgn2	IMP		Rat	PMID:15681343\|RGD:8553420
Biological Process	GO:0051965	positive regulation of synapse assembly	Nlgn2	IDA		Rat	PMID:15797875\|RGD:8554205
Biological Process	GO:0032230	positive regulation of synaptic transmission, GABAergic	Nlgn2	IMP		Mouse	MGI:MGI:5284797\|PMID:15620359
Biological Process	GO:0051968	positive regulation of synaptic transmission, glutamatergic	Nlgn2	IMP		Mouse	MGI:MGI:5284797\|PMID:15620359
Biological Process	GO:2000809	positive regulation of synaptic vesicle clustering	Nlgn2	IDA		Mouse	MGI:MGI:5284797\|PMID:15620359
Biological Process	GO:1904034	positive regulation of t-SNARE clustering	Nlgn2	IDA		Rat	PMID:22528485\|RGD:9743981
Biological Process	GO:0097119	postsynaptic density protein 95 clustering	Nlgn2	IDA		Mouse	MGI:MGI:5284797\|PMID:15620359
Biological Process	GO:0097104	postsynaptic membrane assembly	Nlgn2	IDA		Mouse	MGI:MGI:5284797\|PMID:15620359
Biological Process	GO:0098698	postsynaptic specialization assembly	Nlgn2	IDA		Mouse	PMID:19755106
Biological Process	GO:0098698	postsynaptic specialization assembly	Nlgn2	IMP		Mouse	PMID:19755106
Biological Process	GO:0098698	postsynaptic specialization assembly	Nlgn2	IPI		Mouse	PMID:19755106
Biological Process	GO:0098698	postsynaptic specialization assembly	Nlgn2	IMP		Mouse	PMID:15620359
Biological Process	GO:0098698	postsynaptic specialization assembly	Nlgn2	IDA		Mouse	PMID:15620359
Biological Process	GO:0097105	presynaptic membrane assembly	Nlgn2	IMP		Mouse	MGI:MGI:4352827\|PMID:19016888
Biological Process	GO:0097105	presynaptic membrane assembly	Nlgn2	IDA		Mouse	MGI:MGI:5284797\|PMID:15620359
Biological Process	GO:0097105	presynaptic membrane assembly	Nlgn2	IDA		Rat	PMID:15797875\|RGD:8554205
Biological Process	GO:0034394	protein localization to cell surface	Nlgn2	IMP		Mouse	PMID:29107521
Biological Process	GO:0034394	protein localization to cell surface	Nlgn2	IMP	MGI:MGI:3687639	Mouse	PMID:29107521
Biological Process	GO:0034394	protein localization to cell surface	Nlgn2	IDA		Mouse	PMID:29107521
Biological Process	GO:0035418	protein localization to synapse	Nlgn2	IDA		Mouse	MGI:MGI:5284797\|PMID:15620359
Biological Process	GO:0035418	protein localization to synapse	Nlgn2	IDA		Mouse	MGI:MGI:5780536\|PMID:22960622
Biological Process	GO:2000311	regulation of AMPA receptor activity	Nlgn2	IMP		Mouse	MGI:MGI:5284797\|PMID:15620359
Biological Process	GO:1905606	regulation of presynapse assembly	Nlgn2	IDA		Rat	PMID:10892652\|RGD:13702379
Biological Process	GO:1905606	regulation of presynapse assembly	Nlgn2	IMP		Rat	PMID:10892652\|RGD:13702379
Biological Process	GO:0002087	regulation of respiratory gaseous exchange by nervous system process	Nlgn2	IGI	MGI:MGI:2444609	Mouse	PMID:16982420
Biological Process	GO:0019233	sensory perception of pain	Nlgn2	IMP		Mouse	MGI:MGI:4352827\|PMID:19016888
Biological Process	GO:0035176	social behavior	Nlgn2	IMP		Rat	PMID:18550748\|RGD:8554527
Biological Process	GO:0007416	synapse assembly	Nlgn2	IDA		Rat	PMID:15797875\|RGD:8554205
Biological Process	GO:0050808	synapse organization	Nlgn2	IDA		Rat	PMID:15681343\|RGD:8553420
Biological Process	GO:0050808	synapse organization	Nlgn2	IDA		Rat	PMID:19285470\|RGD:8554788
Biological Process	GO:0051932	synaptic transmission, GABAergic	Nlgn2	IGI	MGI:MGI:2679447	Mouse	PMID:29107521
Biological Process	GO:0051932	synaptic transmission, GABAergic	Nlgn2	IMP		Mouse	PMID:29107521
Biological Process	GO:0051932	synaptic transmission, GABAergic	Nlgn2	IMP	MGI:MGI:3687639	Mouse	PMID:29107521
Biological Process	GO:0051932	synaptic transmission, GABAergic	Nlgn2	IDA		Mouse	PMID:29107521
Biological Process	GO:0072553	terminal button organization	Nlgn2	IMP		Rat	PMID:18550748\|RGD:8554527
Biological Process	GO:0001966	thigmotaxis	Nlgn2	IMP		Rat	PMID:18550748\|RGD:8554527

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/07/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.