Nlgn2
Gene Detail

Symbol Name ID

Nlgn2 neuroligin 2 MGI:2681835

Synonyms

MGC:67386, NL2

Feature Type

protein coding gene

Genetic Map

Chromosome 11

42.89 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr11:69823122-69837784 bp, - strand From VEGA annotation of GRCm38   14663 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:69317  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 zebrafish

Gene Tree: Nlgn2

Human homologs

Human Homolog		NLGN2, neuroligin 2
NCBI Gene ID		57555
neXtProt AC		NX_Q8NFZ4
Human Chr (Location)		17p13.1; chr17:7311502-7323179 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(7) : Targeted(3) Gene trapped(4)

Gene Ontology (GO) classifications

All GO classifications: (48 annotations)

Process	cell adhesion, gephyrin clustering, ...
Component	cell junction, cell surface, ...
Function	cell adhesion molecule binding, neurexin family protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
cDNA source data(94)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(94) cDNA(94)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000005998 (Evidence)
Ensembl Gene Model	ENSMUSG00000051790 (Evidence)
Entrez Gene	216856 (Evidence)
UniGene	151293
DFCI	TC1579391, TC1597673, TC1706826
DoTS	DT.101246570, DT.110521965, DT.110521978, DT.99854048
NIA Mouse Gene Index	U032984, U316722
PDB	3BL8
Consensus CDS Project	CCDS24914.1
International Mouse Knockout Project Status	Nlgn2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005998	VEGA Gene Model | MGI Sequence Detail	14663	C57BL/6J
transcript	OTTMUST00000077459	VEGA | MGI Sequence Detail	5003	Not Applicable
polypeptide	OTTMUSP00000040960	VEGA | MGI Sequence Detail	836	Not Applicable

All sequences(42) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(32 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002018	Carboxylesterase, type B
InterPro	IPR019819	Carboxylesterase type B, conserved site
InterPro	IPR000460	Neuroligin
Protein Ontology	PR:000011255	neuroligin-2

References

(Earliest) J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
(Latest) J:194221 Gkogkas CG, et al., Autism-related deficits via dysregulated eIF4E-dependent translational control. Nature. 2013 Jan 17;493(7432):371-7
All references(54)