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Nlgn2
Gene Detail
 Symbol
Name
ID
Nlgn2
neuroligin 2
MGI:2681835
Synonyms MGC:67386, NL2
Feature Type protein coding gene
Genetic Map
Chromosome 11
42.89 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr11:69823122-69837784 bp, - strand
From VEGA annotation of GRCm38

  14663 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:69317  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 2 zebrafish

Gene Tree: Nlgn2

Human
homologs
Human Homolog NLGN2, neuroligin 2
NCBI Gene ID 57555
neXtProt AC  NX_Q8NFZ4
Human Chr (Location)  17p13.1; chr17:7408183-7419864 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(4) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Nlgn2 interacts with 234 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (48 annotations)
Process cell adhesion, gephyrin clustering, ...
Component cell junction, cell surface, ...
Function cell adhesion molecule binding, neurexin family protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
cDNA source data(93)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(93) cDNA(93)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000005998 (Evidence)
Ensembl Gene ModelENSMUSG00000051790 (Evidence)
Entrez Gene216856 (Evidence)
UniGene151293
DFCITC1579391, TC1597673, TC1706826
DoTSDT.101246570, DT.110521965, DT.110521978, DT.99854048
NIA Mouse Gene IndexU032984, U316722
PDB3BL8
Consensus CDS ProjectCCDS24914.1
International Mouse Knockout Project StatusNlgn2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005998 VEGA Gene Model | MGI Sequence Detail 14663 C57BL/6J ±  kb
transcript OTTMUST00000077459 VEGA | MGI Sequence Detail 5003 Not Applicable 
polypeptide OTTMUSP00000040960 VEGA | MGI Sequence Detail 836 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(8) UniProt(4)
Polymorphisms SNPs within 2kb(79 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002018 Carboxylesterase, type B
InterPro IPR019819 Carboxylesterase type B, conserved site
InterPro IPR000460 Neuroligin
Protein Ontology PR:000011255 neuroligin-2
References (Earliest) J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
(Latest) J:205922 Takacs VT, et al., Neuroligin 2 is expressed in synapses established by cholinergic cells in the mouse brain. PLoS One. 2013;8(9):e72450
All references(60)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory