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Nlgn2
Gene Detail
Symbol

Name
ID
Nlgn2
neuroligin 2
MGI:2681835
Synonyms
MGC:67386, NL2
Feature Type
protein coding gene
Genetic Map
Chromosome 11
42.89 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr11:69823122-69837784 bp, - strand
From VEGA annotation of GRCm38

  14663 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:69317  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: NLGN2
Gene Tree: Nlgn2

Human
homologs
NLGN2, neuroligin 2
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 57555
neXtProt AC: NX_Q8NFZ4

Human Chr (Location): 17p13.1; chr17:7408183-7419864 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(4) Targeted(5) Transgenic(1)
Genomic Mutations involving Nlgn2 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Nlgn2 interacts with 234 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (4 records)
cDNA source data(93)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase nlgn2 ; ZFIN nlgn2a, nlgn2b    NEW 
Molecular
reagents
All nucleic(93) cDNA(93)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000005998 (Evidence)
Ensembl Gene Model ENSMUSG00000051790 (Evidence)
Entrez Gene 216856 (Evidence)
UniGene 151293
DFCI TC1706826, TC1597673, TC1579391
DoTS DT.101246570, DT.110521965, DT.110521978, DT.99854048
NIA Mouse Gene Index U316722, U032984
PDB 3BL8
Consensus CDS Project CCDS24914.1
International Mouse Phenotyping Consortium Status Nlgn2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005998 VEGA Gene Model | MGI Sequence Detail 14663 C57BL/6J ±  kb
transcript OTTMUST00000013425 VEGA | MGI Sequence Detail 5568 Not Applicable 
polypeptide OTTMUSP00000006214 VEGA | MGI Sequence Detail 836 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(8) UniProt(4)
Polymorphisms
SNPs within 2kb(79 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002018 Carboxylesterase, type B
InterPro IPR019819 Carboxylesterase type B, conserved site
InterPro IPR000460 Neuroligin
Protein Ontology PR:000011255 neuroligin-2
References
(Earliest) J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
(Latest) J:216073 Soykan T, et al., A conformational switch in collybistin determines the differentiation of inhibitory postsynapses. EMBO J. 2014 Sep 17;33(18):2113-33
All references(60)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory