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Nlgn2 Gene Detail
Summary
  • Symbol
    Nlgn2
  • Name
    neuroligin 2
  • Synonyms
    MGC:67386, NL2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2681835
    NCBI Gene: 216856
  • Gene Overview
    MyGene.info: NLGN2
Location & Maps
more
  • Sequence Map
    Chr11:69823122-69837784 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      14663 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 42.89 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    NLGN2, neuroligin 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NLGN2, neuroligin 2
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 57555
    neXtProt AC: NX_Q8NFZ4

  • Chr Location
    17p13.1; chr17:7408183-7419864 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 2 alleles in 3 genetic backgrounds
    14 phenotypes from multigenic genotypes
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (other)
    1
  • Gene trapped
    4
  • Targeted
    5
  • Transgenic
    1
  • Genomic Mutations
    2 involving Nlgn2
  • Incidental Mutations
Mice homozygous for a conditional ready allele are viable and fertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005998 VEGA Gene Model | MGI Sequence Detail 14663 C57BL/6J ±  kb
transcript OTTMUST00000013425 VEGA | MGI Sequence Detail 5568 Not Applicable  
polypeptide OTTMUSP00000006214 VEGA | MGI Sequence Detail 836 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    81 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 93
    cDNA 93

    Microarray probesets 4
References
more
  • Summaries
    All 62
    Developmental Gene Expression 4
    Gene Ontology 14
    Phenotypes 28
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:229887 Liang J, et al., Conditional neuroligin-2 knockout in adult medial prefrontal cortex links chronic changes in synaptic inhibition to cognitive impairments. Mol Psychiatry. 2015 Jul;20(7):850-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory