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Nlgn2 Gene Detail
Summary
  • Symbol
    Nlgn2
  • Name
    neuroligin 2
  • Synonyms
    MGC:67386, NL2, NLG2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2681835
    NCBI Gene: 216856
  • Gene Overview
    MyGene.info: NLGN2
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:69823122-69837784 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 42.89 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    81 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2681835
protein coding gene Chr11:69823122-69838061 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018559
protein coding gene Chr11:70306315-70320975 (-)
A/J MGP_AJ_G0018527
protein coding gene Chr11:67643741-67658386 (-)
AKR/J MGP_AKRJ_G0018496
protein coding gene Chr11:69663139-69677833 (-)
BALB/cJ MGP_BALBcJ_G0018499
protein coding gene Chr11:67971203-67986192 (-)
C3H/HeJ MGP_C3HHeJ_G0018312
protein coding gene Chr11:69696915-69711246 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018950
protein coding gene Chr11:72427042-72444529 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016595
protein coding gene Chr11:64566868-64581745 (-)
CAST/EiJ MGP_CASTEiJ_G0017867
protein coding gene Chr11:69934585-69950253 (-)
CBA/J MGP_CBAJ_G0018285
protein coding gene Chr11:75669150-75683808 (-)
DBA/2J MGP_DBA2J_G0018394
protein coding gene Chr11:67227373-67242050 (-)
FVB/NJ MGP_FVBNJ_G0018384
protein coding gene Chr11:66867711-66882354 (-)
LP/J MGP_LPJ_G0018464
protein coding gene Chr11:70868304-70884748 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018407
protein coding gene Chr11:76275706-76290420 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018992
protein coding gene Chr11:69926264-69940919 (-)
PWK/PhJ MGP_PWKPhJ_G0017641
protein coding gene Chr11:67877001-67892051 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017431
protein coding gene Chr11:69746701-69761382 (-)
WSB/EiJ MGP_WSBEiJ_G0017921
protein coding gene Chr11:69594042-69608691 (-)



Homology
more
  • Human Ortholog
    NLGN2, neuroligin 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NLGN2, neuroligin 2
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 57555
    neXtProt AC: NX_Q8NFZ4
    UniProt: Q8NFZ4

  • Chr Location
    17p13.1; chr17:7405492-7419864 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 2 alleles in 3 genetic backgrounds
    14 phenotypes from multigenic genotypes
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional ready allele are viable and fertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000051790 Ensembl Gene Model | MGI Sequence Detail 14663 C57BL/6J ±  kb
transcript ENSMUST00000056484 Ensembl | MGI Sequence Detail 5003 Not Applicable  
polypeptide ENSMUSP00000053097 Ensembl | MGI Sequence Detail 836 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 95
    cDNA 95

    Microarray probesets 4
References
more
  • Summaries
    All 93
    Developmental Gene Expression 7
    Gene Ontology 20
    Phenotypes 37
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:265620 Wu M, et al., Impairment of Inhibitory Synapse Formation and Motor Behavior in Mice Lacking the NL2 Binding Partner LHFPL4/GARLH4. Cell Rep. 2018 May 8;23(6):1691-1705

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory