Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NFIC
  • Mouse genes Nfic
  • Rat genes Nfic
  • Zfish genes nfic
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nfic

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0000987	cis-regulatory region sequence-specific DNA binding	Nfic	IDA		Rat	PMID:10521600|RGD:633408
Molecular Function	GO:0003677	DNA binding	Nfic	IDA		Rat	PMID:18602130|RGD:2303788
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	NFIC	IDA		Human	PMID:1524678
Molecular Function	GO:0003700	DNA-binding transcription factor activity	NFIC	IDA		Human	PMID:1524678
Molecular Function	GO:0003690	double-stranded DNA binding	Nfic	IDA		Rat	PMID:10521600|RGD:633408
Molecular Function	GO:0005515	protein binding	NFIC	IPI	UniProtKB:O00712	Human	PMID:25258084
Molecular Function	GO:0005515	protein binding	NFIC	IPI	UniProtKB:O00712	Human	PMID:35140242
Molecular Function	GO:0005515	protein binding	Nfic	IPI	RGD:3170	Rat	PMID:18602130|RGD:2303788
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	NFIC	IDA		Human	PMID:1524678
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	NFIC	IDA		Human	PMID:28473536
Cellular Component	GO:0001650	fibrillar center	NFIC	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	NFIC	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Nfic	IDA		Rat	PMID:18602130|RGD:2303788
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Nfic	IDA		Rat	PMID:18602130|RGD:2303788
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	NFIC	IGI	UniProtKB:O89090	Human	PMID:1524678
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	NFIC	IDA		Human	PMID:19706729
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Nfic	IDA		Mouse	MGI:MGI:4461125|PMID:19706729
Biological Process	GO:0042475	odontogenesis of dentin-containing tooth	Nfic	IMP	MGI:MGI:2450153	Mouse	PMID:12529411
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	NFIC	IDA		Human	PMID:1524678
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	NFIC	IDA		Human	PMID:19706729
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nfic	IDA		Mouse	MGI:MGI:4461125|PMID:19706729
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nfic	IDA		Mouse	PMID:9056636

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern