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Gene Detail
nuclear factor I/C
Synonyms 1110019L22Rik, 1500041O16Rik, NF1-C, nuclear factor 1-C2
Feature Type protein coding gene
Genetic Map
Chromosome 10
39.72 cM, cytoband C1
Detailed Genetic Map ± 1 cM

Mapping data(6)
Sequence Map
Chr10:81396186-81431005 bp, - strand
From VEGA annotation of GRCm38

  34820 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:4088  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: nuclear factor 1
Gene Tree: Nfic

Human Homolog NFIC, nuclear factor I/C (CCAAT-binding transcription factor)
NCBI Gene ID 4782
neXtProt AC  NX_P08651
Human Synonyms  CTF, CTF5, NFI, NF-I
Human Chr (Location)  19p13.3; chr19:3359563-3469217 (+)  GRCh38
alleles, and
All mutations/alleles(31) : Gene trapped(30) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
Mice homozygous for a targeted null allele have abnormal incisor and molar root development, show reduced alveolar bone formation, and exhibit impaired feeding leading to severe runting and premature death when reared on standard laboratory chow.
Nfic interacts with 393 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
All GO classifications: (19 annotations)
Process DNA replication, negative regulation of transcription, DNA-templated, ...
Component intracellular, nucleolus, ...
Function core promoter proximal region DNA binding, DNA binding, ...
External Resources: FuncBase
Literature Summary: (10 records)
Data Summary: Results (178)    Tissues (96)    Images (70)
Theiler Stages: 13, 14, 17, 19, 20, 21, 22, 23, 24, 26, 27, 28
Assay TypeResults
RNA in situ 170
Northern blot 8
cDNA source data(19)
External Resources: Allen Institute   GEO   Expression Atlas
All nucleic(23) cDNA(22) Other(1)
Microarray probesets(9)
Other database
VEGA Gene ModelOTTMUSG00000030419 (Evidence)
Ensembl Gene ModelENSMUSG00000055053 (Evidence)
Entrez Gene18029 (Evidence)
DFCITC1578403, TC1580792, TC1626650, TC1634776, TC1637656, TC1648741, TC1693567, TC1715485
DoTSDT.101321347, DT.101376401, DT.101724785, DT.40143299, DT.94338144
NIA Mouse Gene IndexU032046
Consensus CDS ProjectCCDS24058.1, CCDS35999.1
International Mouse Knockout Project StatusNfic
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030419 VEGA Gene Model | MGI Sequence Detail 34820 C57BL/6J ±  kb
transcript OTTMUST00000075330 VEGA | MGI Sequence Detail 3348 Not Applicable 
polypeptide OTTMUSP00000039462 VEGA | MGI Sequence Detail 439 Not Applicable 

For the selected sequences
All sequences(82) RefSeq(6) UniProt(4)
Polymorphisms RFLP(1) : SNPs within 2kb(20 from dbSNP Build 137)
InterPro IPR000647 CTF transcription factor/nuclear factor 1
InterPro IPR019739 CTF transcription factor/nuclear factor 1, conserved site
InterPro IPR020604 CTF transcription factor/nuclear factor 1, DNA-binding domain
InterPro IPR019548 CTF transcription factor/nuclear factor 1, N-terminal
InterPro IPR003619 MAD homology 1, Dwarfin-type
Protein Ontology PR:000011175 nuclear factor 1 C-type
References (Earliest) J:39019 Chaudhry AZ, et al., Expression patterns of the four nuclear factor I genes during mouse embryogenesis indicate a potential role in development. Dev Dyn. 1997 Mar;208(3):313-25
(Latest) J:182875 Wang W, et al., Temporal control of a dendritogenesis-linked gene via REST-dependent regulation of nuclear factor I occupancy. Mol Biol Cell. 2011 Mar 15;22(6):868-79
All references(58)
accession IDs
MGD-MRK-39590, MGI:1915780, MGI:1916250, MGI:2143494, MGI:2143666

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory