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Nfic Gene Detail
Summary
  • Symbol
    Nfic
  • Name
    nuclear factor I/C
  • Synonyms
    1110019L22Rik, 1500041O16Rik, NF1-C, nuclear factor 1-C2
  • Feature Type
    protein coding gene
  • IDs
    MGI:109591
    NCBI Gene: 18029
  • Gene Overview
    MyGene.info: NFIC
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr10:81396186-81431005 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      34820 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 39.72 cM, cytoband C1
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    NFIC, nuclear factor I C
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NFIC, nuclear factor I C
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CTF, CTF5, NFI, NF-I
  • Links
    NCBI Gene ID: 4782
    neXtProt AC: NX_P08651
    UniProt: P08651

  • Chr Location
    19p13.3; chr19:3359563-3469217 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 1 allele in 2 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null allele have abnormal incisor and molar root development, show reduced alveolar bone formation, and exhibit impaired feeding leading to severe runting and premature death when reared on standard laboratory chow.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000030419 VEGA Gene Model | MGI Sequence Detail 34820 C57BL/6J ±  kb
    transcript OTTMUST00000075330 VEGA | MGI Sequence Detail 3348 Not Applicable  
    polypeptide OTTMUSP00000039462 VEGA | MGI Sequence Detail 439 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      20 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000011175 nuclear factor 1 C-type
    • InterPro Domains
      IPR000647 CTF transcription factor/nuclear factor 1
      IPR019739 CTF transcription factor/nuclear factor 1, conserved site
      IPR020604 CTF transcription factor/nuclear factor 1, DNA-binding domain
      IPR019548 CTF transcription factor/nuclear factor 1, N-terminal
      IPR003619 MAD homology 1, Dwarfin-type
    Molecular
    Reagents
    less
    • All nucleic 23
      cDNA 22
      Other 1

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGD-MRK-39590, MGI:1915780, MGI:1916250, MGI:2143494, MGI:2143666
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 10
      Gene Ontology 9
      Phenotypes 19
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:239785 Liu Y, et al., An Nfic-hedgehog signaling cascade regulates tooth root development. Development. 2015 Oct 01;142(19):3374-82

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory