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Nfic Gene Detail
Summary
  • Symbol
    Nfic
  • Name
    nuclear factor I/C
  • Synonyms
    1110019L22Rik, 1500041O16Rik, NF1-C, nuclear factor 1-C2
  • Feature Type
    protein coding gene
  • IDs
    MGI:109591
    NCBI Gene: 18029
  • Gene Overview
    MyGene.info: NFIC
Location & Maps
more
  • Sequence Map
    Chr10:81396186-81431005 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      34820 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 39.72 cM, cytoband C1
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    NFIC, nuclear factor I C
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NFIC, nuclear factor I C
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CTF, CTF5, NFI, NF-I
  • Links
    NCBI Gene ID: 4782
    neXtProt AC: NX_P08651

  • Chr Location
    19p13.3; chr19:3359563-3469217 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 1 allele in 2 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    32
  • Chemically induced (other)
    1
  • Gene trapped
    30
  • Targeted
    1
  • Genomic Mutations
    1 involving Nfic
  • Incidental Mutations
Mice homozygous for a targeted null allele have abnormal incisor and molar root development, show reduced alveolar bone formation, and exhibit impaired feeding leading to severe runting and premature death when reared on standard laboratory chow.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030419 VEGA Gene Model | MGI Sequence Detail 34820 C57BL/6J ±  kb
transcript OTTMUST00000075330 VEGA | MGI Sequence Detail 3348 Not Applicable  
polypeptide OTTMUSP00000039462 VEGA | MGI Sequence Detail 439 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    20 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000011175 nuclear factor 1 C-type
  • InterPro Domains
    IPR000647 CTF transcription factor/nuclear factor 1
    IPR019739 CTF transcription factor/nuclear factor 1, conserved site
    IPR020604 CTF transcription factor/nuclear factor 1, DNA-binding domain
    IPR019548 CTF transcription factor/nuclear factor 1, N-terminal
    IPR003619 MAD homology 1, Dwarfin-type
Molecular
Reagents
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  • All nucleic 23
    cDNA 22
    Other 1

    Microarray probesets 9
Other
Accession IDs
less
MGD-MRK-39590, MGI:1915780, MGI:1916250, MGI:2143494, MGI:2143666
References
more
  • Summaries
    All 56
    Developmental Gene Expression 10
    Gene Ontology 8
    Phenotypes 18
  • Earliest
    J:39019 Chaudhry AZ, et al., Expression patterns of the four nuclear factor I genes during mouse embryogenesis indicate a potential role in development. Dev Dyn. 1997 Mar;208(3):313-25
  • Latest
    J:233361 Zhang H, et al., Essential role of osterix for tooth root but not crown dentin formation. J Bone Miner Res. 2015 Apr;30(4):742-6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory