Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NDRG2
  • Mouse genes Ndrg2
  • Rat genes Ndrg2
  • Zfish genes ndrg2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ndrg2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	NDRG2	IPI	UniProtKB:P03372	Human	PMID:21217774
Cellular Component	GO:0005737	cytoplasm	Ndrg2	IDA		Mouse	PMID:16520977
Cellular Component	GO:0070062	extracellular exosome	NDRG2	HDA		Human	PMID:19199708
Cellular Component	GO:0005794	Golgi apparatus	NDRG2	IDA		Human	GO_REF:0000054
Cellular Component	GO:0005634	nucleus	Ndrg2	IDA		Mouse	PMID:16520977
Biological Process	GO:0001818	negative regulation of cytokine production	Ndrg2	IMP		Mouse	PMID:19815093
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	Ndrg2	IMP		Mouse	PMID:19815093
Biological Process	GO:1904706	negative regulation of vascular associated smooth muscle cell proliferation	Ndrg2	IDA		Mouse	PMID:16520977
Biological Process	GO:0090361	regulation of platelet-derived growth factor production	Ndrg2	IMP		Mouse	PMID:19815093
Biological Process	GO:0010574	regulation of vascular endothelial growth factor production	Ndrg2	IMP		Mouse	PMID:19815093
Biological Process	GO:0007165	signal transduction	Ndrg2	IDA		Rat	PMID:12072429|RGD:625480
Biological Process	GO:0021762	substantia nigra development	NDRG2	HEP		Human	PMID:22926577
Biological Process	GO:1990874	vascular associated smooth muscle cell proliferation	Ndrg2	IDA		Mouse	PMID:16520977

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern