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Ndrg2
Gene Detail
Symbol

Name
ID
Ndrg2
N-myc downstream regulated gene 2
MGI:1352498
Synonyms
Ndr2
Feature Type
protein coding gene
Genetic Map
Chromosome 14
26.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr14:51905271-51913488 bp, - strand
From Ensembl annotation of GRCm38

  8218 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22785  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NDRG2
Gene Tree: Ndrg2

Human
homologs
NDRG2, NDRG family member 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 57447
neXtProt AC: NX_Q9UN36

Human Synonyms: SYLD

Human Chr (Location): 14q11.2; chr14:21016763-21070872 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit numerous vertebral transformation.
 
Interactions
Ndrg2 interacts with 158 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process cell differentiation, multicellular organismal development, ...
Component cell projection, centrosome, ...
External Resources: FuncBase
Expression
Literature Summary: (15 records)
Data Summary: Results (458)    Tissues (228)    Images (50)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 453
RT-PCR 5
cDNA source data(220)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ndrg2 ; ZFIN ndrg2    NEW 
Molecular
reagents
All nucleic(223) cDNA(220) Primer pair(3)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000004558 (Evidence)
Entrez Gene 29811 (Evidence)
UniGene 26722
DFCI TC1573601, TC1700921
DoTS DT.101206833, DT.87073021, DT.94372322
NIA Mouse Gene Index U035528
PDB 2QMQ
Consensus CDS Project CCDS27047.1, CCDS49486.1
International Mouse Phenotyping Consortium Status Ndrg2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000004558 Ensembl Gene Model | MGI Sequence Detail 8218 C57BL/6J ±  kb
transcript ENSMUST00000004673 Ensembl | MGI Sequence Detail 2157 Not Applicable 
polypeptide ENSMUSP00000004673 Ensembl | MGI Sequence Detail 371 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(24) UniProt(2)
Polymorphisms
SNPs within 2kb(104 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR029058 Alpha/Beta hydrolase fold
InterPro IPR004142 NDRG
InterPro IPR030690 Protein NDRG2
Protein Ontology PR:000011060 protein NDRG2
References
(Earliest) J:58924 Okuda T, et al., Identification of new genes ndr2 and ndr3 which are related to Ndr1/RTP/Drg1 but show distinct tissue specificity and response to N-myc. Biochem Biophys Res Commun. 1999 Dec 9;266(1):208-15
(Latest) J:214686 Takarada-Iemata M, et al., Deletion of N-myc downstream-regulated gene 2 attenuates reactive astrogliosis and inflammatory response in a mouse model of cortical stab injury. J Neurochem. 2014 Aug;130(3):374-87
All references(53)
Other
accession IDs
MGI:2145602, MGI:2145752

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory