Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MSR1
  • Mouse genes Msr1
  • Rat genes Msr1
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Msr1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001540	amyloid-beta binding	Msr1	IGI	UniProtKB:Q61009	Mouse	MGI:MGI:5902691|PMID:11240025
Molecular Function	GO:0038024	cargo receptor activity	Msr1	IGI	UniProtKB:P01027,UniProtKB:P05555	Mouse	MGI:MGI:5319446|PMID:22438044
Molecular Function	GO:0030169	low-density lipoprotein particle binding	Msr1	IMP		Mouse	MGI:MGI:2447499|PMID:12376530
Molecular Function	GO:0005515	protein binding	MSR1	IPI	UniProtKB:Q7TQ77	Human	PMID:17237231
Molecular Function	GO:0005515	protein binding	MSR1	IPI	UniProtKB:Q86VS8	Human	PMID:17237231
Molecular Function	GO:0005515	protein binding	MSR1	IPI	UniProtKB:P27449	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MSR1	IPI	UniProtKB:Q13021	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MSR1	IPI	UniProtKB:Q16617	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MSR1	IPI	UniProtKB:Q6FHL7	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MSR1	IPI	UniProtKB:Q96IW7	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MSR1	IPI	UniProtKB:Q92614	Human	PMID:25965346
Molecular Function	GO:0005515	protein binding	MSR1	IPI	UniProtKB:O95214	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	MSR1	IPI	UniProtKB:Q16617	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	MSR1	IPI	UniProtKB:Q96IW7	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	MSR1	IPI	UniProtKB:O95214	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MSR1	IPI	UniProtKB:P27449	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MSR1	IPI	UniProtKB:Q13021	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MSR1	IPI	UniProtKB:Q16617	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MSR1	IPI	UniProtKB:Q7L5A8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MSR1	IPI	UniProtKB:Q96IW7	Human	PMID:32296183
Cellular Component	GO:0031410	cytoplasmic vesicle	Msr1	IDA		Rat	PMID:14993215|RGD:2306155
Cellular Component	GO:0005829	cytosol	Msr1	IDA		Rat	PMID:16276974|RGD:1582670
Cellular Component	GO:0005886	plasma membrane	Msr1	IMP		Mouse	MGI:MGI:5902691|PMID:11240025
Cellular Component	GO:0005886	plasma membrane	Msr1	IDA		Rat	PMID:14993215|RGD:2306155
Biological Process	GO:0097242	amyloid-beta clearance	Msr1	IMP		Mouse	MGI:MGI:5902691|PMID:11240025
Biological Process	GO:0097242	amyloid-beta clearance	Msr1	IGI	UniProtKB:P01027|UniProtKB:P05555	Mouse	MGI:MGI:5319446|PMID:22438044
Biological Process	GO:0071407	cellular response to organic cyclic compound	Msr1	IEP		Rat	PMID:16276974|RGD:1582670
Biological Process	GO:0030301	cholesterol transport	Msr1	IMP		Mouse	MGI:MGI:2447499|PMID:12376530
Biological Process	GO:0051649	establishment of localization in cell	Msr1	IMP	MGI:MGI:1857874	Mouse	PMID:17148552
Biological Process	GO:0042953	lipoprotein transport	Msr1	IMP	MGI:MGI:1857874	Mouse	PMID:17148552
Biological Process	GO:0010629	negative regulation of gene expression	Msr1	IMP		Mouse	MGI:MGI:5902691|PMID:11240025
Biological Process	GO:0006911	phagocytosis, engulfment	Msr1	IGI	UniProtKB:P01027|UniProtKB:P05555	Mouse	MGI:MGI:5319446|PMID:22438044
Biological Process	GO:0034381	plasma lipoprotein particle clearance	Msr1	IMP		Mouse	MGI:MGI:2447499|PMID:12376530
Biological Process	GO:0010886	positive regulation of cholesterol storage	Msr1	IMP		Mouse	MGI:MGI:2447499|PMID:12376530
Biological Process	GO:0010744	positive regulation of macrophage derived foam cell differentiation	Msr1	IGI	UniProtKB:Q08857	Mouse	MGI:MGI:2447499|PMID:12376530
Biological Process	GO:0006898	receptor-mediated endocytosis	Msr1	IGI	UniProtKB:P01027,UniProtKB:P05555	Mouse	MGI:MGI:5319446|PMID:22438044

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern