Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MKX
  • Mouse genes Mkx
  • Rat genes Mkx
  • Zfish genes mkxa,mkxb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mkx

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	mkxa	IDA		Zfish	PMID:24814716
Molecular Function	GO:0003677	DNA binding	mkxa	IGI	ZFIN:ZDB-GENE-980526-561,ZFIN:ZDB-MRPHLNO-100506-4	Zfish	PMID:24814716
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Mkx	IMP		Mouse	MGI:MGI:5574289|PMID:22923612
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Mkx	IDA		Mouse	MGI:MGI:5574289|PMID:22923612
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Mkx	IDA		Mouse	PMID:19235719
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Mkx	IMP		Mouse	MGI:MGI:5574289|PMID:22923612
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Mkx	IDA		Mouse	MGI:MGI:5574289|PMID:22923612
Molecular Function	GO:0005515	protein binding	Mkx	IPI	PR:Q60520	Mouse	PMID:19235719
Molecular Function	GO:0005515	protein binding	Mkx	IPI	PR:O09106	Mouse	PMID:19235719
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Mkx	IDA		Mouse	MGI:MGI:5574289|PMID:22923612
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	Mkx	IPI	PR:Q99PM3	Mouse	PMID:19235719
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	Mkx	IPI	PR:Q80ZM7	Mouse	PMID:19235719
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	Mkx	IPI	PR:P29037	Mouse	PMID:19235719
Biological Process	GO:0071260	cellular response to mechanical stimulus	Mkx	IMP		Rat	PMID:27370800|RGD:40924660
Biological Process	GO:0030199	collagen fibril organization	Mkx	IMP	MGI:MGI:5287572	Mouse	PMID:20696843
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	mkxa	IMP	ZFIN:ZDB-MRPHLNO-100506-5	Zfish	PMID:20014404
Biological Process	GO:0036077	intratendonous ossification	Mkx	IMP		Rat	PMID:27370800|RGD:40924660
Biological Process	GO:0007517	muscle organ development	Mkx	IEP		Mouse	MGI:MGI:3617684|PMID:16408284
Biological Process	GO:0045445	myoblast differentiation	mkxa	IMP	ZFIN:ZDB-MRPHLNO-100506-4	Zfish	PMID:24814716
Biological Process	GO:0032331	negative regulation of chondrocyte differentiation	Mkx	IMP		Rat	PMID:27370800|RGD:40924660
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	mkxa	IMP	ZFIN:ZDB-MRPHLNO-100506-4	Zfish	PMID:24814716
Biological Process	GO:0045599	negative regulation of fat cell differentiation	Mkx	IMP		Rat	PMID:27370800|RGD:40924660
Biological Process	GO:0045662	negative regulation of myoblast differentiation	Mkx	IDA		Mouse	PMID:19235719
Biological Process	GO:0030279	negative regulation of ossification	Mkx	IMP		Rat	PMID:27370800|RGD:40924660
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Mkx	IMP		Mouse	MGI:MGI:5574289|PMID:22923612
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Mkx	IDA		Mouse	PMID:19235719
Biological Process	GO:0032967	positive regulation of collagen biosynthetic process	Mkx	IMP	MGI:MGI:4461224	Mouse	PMID:20498044
Biological Process	GO:0010628	positive regulation of gene expression	Mkx	IMP	MGI:MGI:5287572	Mouse	PMID:20696843
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Mkx	IMP		Mouse	MGI:MGI:5574289|PMID:22923612
Biological Process	GO:0010468	regulation of gene expression	Mkx	IMP	MGI:MGI:4461224	Mouse	PMID:20498044
Biological Process	GO:0035990	tendon cell differentiation	Mkx	IMP	MGI:MGI:5287572	Mouse	PMID:20696843
Biological Process	GO:0035990	tendon cell differentiation	Mkx	IMP		Rat	PMID:27370800|RGD:40924660
Biological Process	GO:0035992	tendon formation	Mkx	IMP	MGI:MGI:5287572	Mouse	PMID:20696843
Biological Process	GO:0035992	tendon formation	Mkx	IMP	MGI:MGI:4887450	Mouse	PMID:21254332
Biological Process	GO:0035992	tendon formation	Mkx	IMP	MGI:MGI:4461224	Mouse	PMID:20498044
Biological Process	GO:0002932	tendon sheath development	Mkx	IMP	MGI:MGI:5287572	Mouse	PMID:20696843

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern