About   Help   FAQ
Mkx Gene Detail
Summary
  • Symbol
    Mkx
  • Name
    mohawk homeobox
  • Synonyms
    9430023B20Rik, Irxl1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2687286
    NCBI Gene: 210719
  • Gene Overview
    MyGene.info: MKX
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr18:6910459-7004780 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      94322 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 4.53 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    MKX, mohawk homeobox
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MKX, mohawk homeobox
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C10orf48, IFRX, IRXL1
  • Links
    NCBI Gene ID: 283078
    neXtProt AC: NX_Q8IYA7
    UniProt: Q8IYA7

  • Chr Location
    10p12.1; chr10:27672874-27745849 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 72239
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MKX
  • Gene Tree
    Mkx
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 4 alleles in 4 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit thin, hypoplastic tendons with reduced tensile strength.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000040097 VEGA Gene Model | MGI Sequence Detail 94322 C57BL/6J ±  kb
    transcript OTTMUST00000104159 VEGA | MGI Sequence Detail 3202 Not Applicable  
    polypeptide OTTMUSP00000058261 VEGA | MGI Sequence Detail 354 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      604 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 17
      Primer pair 4
      Other 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 12
      Gene Ontology 7
      Phenotypes 7
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:238417 Koda N, et al., The transcription factor mohawk homeobox regulates homeostasis of the periodontal ligament. Development. 2017 Jan 15;144(2):313-320

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory