Mkx
Gene Detail

Symbol Name ID

Mkx mohawk homeobox MGI:2687286

Synonyms

9430023B20Rik, Irxl1

Feature Type

protein coding gene

Genetic Map

Chromosome 18

4.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr18:6935000-7004726 bp, - strand From VEGA annotation of GRCm38   69727 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:72239  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Mkx

Human homologs

Human Homolog		MKX, mohawk homeobox
NCBI Gene ID		283078
neXtProt AC		NX_Q8IYA7
Human Synonyms		C10orf48, IFRX, IRXL1
Human Chr (Location)		10p12.1; chr10:27961803-28034778 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(7) : Targeted(7)
 

Mice homozygous for a knock-out allele exhibit thin, hypoplastic tendons with reduced tensile strength.

 

Gene Ontology (GO) classifications

All GO classifications: (26 annotations)

Process	collagen fibril organization, multicellular organismal development, ...
Component	nucleus, transcription factor complex
Function	DNA binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (10 records)
Data Summary: Results (150)    Tissues (115)    Images (54)
Theiler Stages: 2, 3, 4, 5, 13, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 28

Assay Type	Results
RNA in situ	122
In situ reporter (knock in)	6
RT-PCR	22

cDNA source data(15)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(19) cDNA(15) Primer pair(3) Other(1)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000040097 (Evidence)
Ensembl Gene Model	ENSMUSG00000061013 (Evidence)
Entrez Gene	210719 (Evidence)
UniGene	257186
DFCI	TC1582952
DoTS	DT.101303361
Consensus CDS Project	CCDS37728.1
International Mouse Knockout Project Status	Mkx

Sequences

Length	Strain/Species
genomic	OTTMUSG00000040097	VEGA Gene Model | MGI Sequence Detail	69727	C57BL/6J
transcript	OTTMUST00000104159	VEGA | MGI Sequence Detail	3102	Not Applicable
polypeptide	OTTMUSP00000058261	VEGA | MGI Sequence Detail	354	Not Applicable

All sequences(24) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(394 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017970	Homeobox, conserved site
InterPro	IPR008422	Homeobox KN domain
InterPro	IPR001356	Homeodomain
InterPro	IPR009057	Homeodomain-like
Protein Ontology	PR:000010435	homeobox protein Mohawk

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:167977 Kimura W, et al., Irxl1 mutant mice show reduced tendon differentiation and no patterning defects in musculoskeletal system development. Genesis. 2011 Jan;49(1):2-9
All references(36)