Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MICAL2
  • Mouse genes Mical2
  • Rat genes Mical2
  • Zfish genes mical2a,mical2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mical2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003779	actin binding	MICAL2	IDA		Human	PMID:24440334
Molecular Function	GO:0003779	actin binding	Mical2	IDA		Mouse	MGI:MGI:5513026|PMID:23911929
Molecular Function	GO:0051019	mitogen-activated protein kinase binding	Mical2	IPI	UniProtKB:P63085	Mouse	MGI:MGI:3797156|PMID:18241670
Molecular Function	GO:0004497	monooxygenase activity	MICAL2	IDA		Human	PMID:29343822
Molecular Function	GO:0016174	NAD(P)H oxidase H2O2-forming activity	Mical2	IDA		Mouse	MGI:MGI:5918009|PMID:23927065
Molecular Function	GO:0016491	oxidoreductase activity	MICAL2	IDA		Human	PMID:24440334
Molecular Function	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	Mical2	IDA		Mouse	MGI:MGI:5513026|PMID:23911929
Molecular Function	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	Mical2	IDA		Mouse	MGI:MGI:5918009|PMID:23927065
Molecular Function	GO:0005515	protein binding	MICAL2	IPI	UniProtKB:P05067	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MICAL2	IPI	UniProtKB:P14136	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MICAL2	IPI	UniProtKB:P29474	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MICAL2	IPI	UniProtKB:P42858	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MICAL2	IPI	UniProtKB:P49810	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MICAL2	IPI	UniProtKB:P54252	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MICAL2	IPI	UniProtKB:Q8WXH2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MICAL2	IPI	UniProtKB:Q9UBB4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Mical2	IPI		Mouse	PMID:18590835
Cellular Component	GO:0005884	actin filament	MICAL2	IDA		Human	PMID:29343822
Cellular Component	GO:0005737	cytoplasm	Mical2	IDA		Mouse	MGI:MGI:3797156|PMID:18241670
Cellular Component	GO:0005634	nucleus	MICAL2	IDA		Human	PMID:24440334
Biological Process	GO:0030042	actin filament depolymerization	MICAL2	IDA		Human	PMID:24440334
Biological Process	GO:0030042	actin filament depolymerization	MICAL2	IDA		Human	PMID:29343822
Biological Process	GO:0030042	actin filament depolymerization	Mical2	IDA		Mouse	MGI:MGI:5513026|PMID:23911929
Biological Process	GO:0007010	cytoskeleton organization	MICAL2	IDA		Human	PMID:24440334
Biological Process	GO:0007507	heart development	mical2b	IMP		Zfish	PMID:24440334|ZFIN:ZDB-PUB-170525-6
Biological Process	GO:0001947	heart looping	mical2b	IMP		Zfish	PMID:24440334|ZFIN:ZDB-PUB-170525-6
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	MICAL2	IMP		Human	PMID:24440334
Biological Process	GO:0019417	sulfur oxidation	Mical2	IDA		Mouse	MGI:MGI:5513026|PMID:23911929
Biological Process	GO:0019417	sulfur oxidation	Mical2	IDA		Mouse	MGI:MGI:5918009|PMID:23927065

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern