Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MICAL1
  • Mouse genes Mical1
  • Rat genes Mical1
  • Zfish genes mical1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mical1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003779	actin binding	MICAL1	IDA		Human	PMID:21864500
Molecular Function	GO:0003779	actin binding	Mical1	IDA		Mouse	MGI:MGI:5513026|PMID:23911929
Molecular Function	GO:0003779	actin binding	Mical1	IDA		Mouse	MGI:MGI:6210614|PMID:26935886
Molecular Function	GO:0071949	FAD binding	MICAL1	IDA		Human	PMID:21864500
Molecular Function	GO:0071949	FAD binding	Mical1	IDA		Mouse	MGI:MGI:6210614|PMID:26935886
Molecular Function	GO:0004497	monooxygenase activity	MICAL1	IDA		Human	PMID:33393173
Molecular Function	GO:0004497	monooxygenase activity	Mical1	IMP		Mouse	PMID:16275926
Molecular Function	GO:0016174	NAD(P)H oxidase H2O2-forming activity	MICAL1	IDA		Human	PMID:21864500
Molecular Function	GO:0016174	NAD(P)H oxidase H2O2-forming activity	MICAL1	IDA		Human	PMID:26845023
Molecular Function	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	MICAL1	IDA		Human	PMID:21864500
Molecular Function	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	MICAL1	IDA		Human	PMID:26845023
Molecular Function	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	Mical1	IDA		Mouse	MGI:MGI:5513026|PMID:23911929
Molecular Function	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	Mical1	IDA		Mouse	MGI:MGI:6210614|PMID:26935886
Molecular Function	GO:0005515	protein binding	MICAL1	IPI	UniProtKB:P08670	Human	PMID:11827972
Molecular Function	GO:0005515	protein binding	MICAL1	IPI	UniProtKB:Q14511	Human	PMID:11827972
Molecular Function	GO:0005515	protein binding	MICAL1	IPI	UniProtKB:Q15286	Human	PMID:28230050
Molecular Function	GO:0005515	protein binding	MICAL1	IPI	UniProtKB:Q9NQ75-2	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	MICAL1	IPI	UniProtKB:Q9NQ75-2	Human	PMID:31413325
Molecular Function	GO:0005515	protein binding	Mical1	IPI	UniProtKB:A4GW50|UniProtKB:Q91VJ4	Mouse	MGI:MGI:5142343|PMID:21730291
Molecular Function	GO:0019901	protein kinase binding	Mical1	IDA		Mouse	MGI:MGI:5883202|PMID:25007825
Molecular Function	GO:0017124	SH3 domain binding	MICAL1	IPI	UniProtKB:Q14511	Human	PMID:11827972
Molecular Function	GO:0031267	small GTPase binding	Mical1	IPI	UniProtKB:P55258	Mouse	MGI:MGI:5508599|PMID:18094055
Cellular Component	GO:0005884	actin filament	MICAL1	IDA		Human	PMID:33393173
Cellular Component	GO:0005737	cytoplasm	MICAL1	IDA		Human	PMID:11827972
Cellular Component	GO:0005737	cytoplasm	MICAL1	IDA		Human	PMID:24440334
Cellular Component	GO:1990026	hippocampal mossy fiber expansion	Mical1	IMP		Mouse	MGI:MGI:5883202|PMID:25007825
Cellular Component	GO:0045171	intercellular bridge	MICAL1	IDA		Human	PMID:28230050
Cellular Component	GO:0030496	midbody	MICAL1	IDA		Human	PMID:28230050
Biological Process	GO:0030042	actin filament depolymerization	MICAL1	IDA		Human	PMID:21864500
Biological Process	GO:0030042	actin filament depolymerization	MICAL1	IDA		Human	PMID:28230050
Biological Process	GO:0030042	actin filament depolymerization	MICAL1	IDA		Human	PMID:33393173
Biological Process	GO:0030042	actin filament depolymerization	Mical1	IDA		Mouse	MGI:MGI:5513026|PMID:23911929
Biological Process	GO:0043066	negative regulation of apoptotic process	Mical1	IMP		Mouse	MGI:MGI:5142343|PMID:21730291
Biological Process	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	Mical1	IMP		Mouse	MGI:MGI:5142343|PMID:21730291
Biological Process	GO:0001933	negative regulation of protein phosphorylation	Mical1	IMP		Mouse	MGI:MGI:5142343|PMID:21730291
Biological Process	GO:1903305	regulation of regulated secretory pathway	Mical1	IMP		Mouse	MGI:MGI:5883202|PMID:25007825
Biological Process	GO:0019417	sulfur oxidation	Mical1	IDA		Mouse	MGI:MGI:6210614|PMID:26935886
Biological Process	GO:0019417	sulfur oxidation	Mical1	IDA		Mouse	MGI:MGI:5513026|PMID:23911929

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern