Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MELK
  • Mouse genes Melk
  • Rat genes Melk
  • Zfish genes melk
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Melk

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005509	calcium ion binding	MELK	IDA		Human	PMID:16216881
Molecular Function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	MELK	IDA		Human	PMID:16216881
Molecular Function	GO:0005515	protein binding	MELK	IPI	UniProtKB:P30305	Human	PMID:12400006
Molecular Function	GO:0005515	protein binding	MELK	IPI	UniProtKB:P30305	Human	PMID:15908796
Molecular Function	GO:0005515	protein binding	MELK	IPI	UniProtKB:Q9BZR8	Human	PMID:17280616
Molecular Function	GO:0005515	protein binding	Melk	IPI	UniProtKB:O35099	Mouse	MGI:MGI:3829088|PMID:18948261
Molecular Function	GO:0004672	protein kinase activity	Melk	IDA		Mouse	PMID:9305775
Molecular Function	GO:0004674	protein serine/threonine kinase activity	MELK	IDA		Human	PMID:12400006
Molecular Function	GO:0004674	protein serine/threonine kinase activity	MELK	IDA		Human	PMID:15908796
Molecular Function	GO:0004674	protein serine/threonine kinase activity	MELK	IDA		Human	PMID:16216881
Molecular Function	GO:0004674	protein serine/threonine kinase activity	MELK	IDA		Human	PMID:17280616
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Melk	IDA		Mouse	MGI:MGI:3829088|PMID:18948261
Cellular Component	GO:0005938	cell cortex	MELK	IDA		Human	PMID:16159311
Cellular Component	GO:0005737	cytoplasm	Melk	IDA		Mouse	PMID:10417823
Cellular Component	GO:0016020	membrane	MELK	HDA		Human	PMID:19946888
Cellular Component	GO:0005886	plasma membrane	MELK	IDA		Human	PMID:21145462
Biological Process	GO:0006915	apoptotic process	MELK	IDA		Human	PMID:17280616
Biological Process	GO:0008283	cell population proliferation	MELK	IDA		Human	PMID:17280616
Biological Process	GO:0048821	erythrocyte development	melk	IMP	ZFIN:ZDB-MRPHLNO-070130-8	Zfish	PMID:16024803
Biological Process	GO:0030097	hemopoiesis	melk	IMP		Zfish	PMID:16024803|ZFIN:ZDB-PUB-061222-9
Biological Process	GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress	Melk	IDA		Mouse	PMID:18948261
Biological Process	GO:0061351	neural precursor cell proliferation	Melk	IDA		Mouse	MGI:MGI:5285180|PMID:16061694
Biological Process	GO:0043065	positive regulation of apoptotic process	Melk	IDA		Mouse	MGI:MGI:3829088|PMID:18948261
Biological Process	GO:0046777	protein autophosphorylation	MELK	IDA		Human	PMID:16216881
Biological Process	GO:0008016	regulation of heart contraction	melk	IMP	ZFIN:ZDB-MRPHLNO-070130-8	Zfish	PMID:16024803

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern