Melk
Gene Detail

Symbol Name ID

Melk maternal embryonic leucine zipper kinase MGI:106924

Synonyms

mKIAA0175, MPK38

Feature Type

protein coding gene

Genetic Map

Chromosome 4

23.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr4:44300876-44364675 bp, + strand From VEGA annotation of GRCm38   63800 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:32111  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Melk

Human homologs

Human Homolog		MELK, maternal embryonic leucine zipper kinase
NCBI Gene ID		9833
neXtProt AC		NX_Q14680
Human Synonyms		HPK38
Human Chr (Location)		9p13.2; chr9:36572859-36677680 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(10) : Targeted(2) Gene trapped(8)

Gene Ontology (GO) classifications

All GO classifications: (29 annotations)

Process	apoptotic process, cell cycle, ...
Component	cell cortex, cytoplasm, ...
Function	ATP binding, calcium ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (424)    Tissues (147)    Images (45)
Theiler Stages: 1, 2, 3, 4, 21, 22, 23, 25, 28

Assay Type	Results
RNA in situ	417
RT-PCR	7

cDNA source data(101)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(104) cDNA(101) Primer pair(2) Other(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000006665 (Evidence)
Ensembl Gene Model	ENSMUSG00000035683 (Evidence)
Entrez Gene	17279 (Evidence)
UniGene	268668
DFCI	TC1575265, TC1628319
DoTS	DT.101281698, DT.532607, DT.94251346, DT.97383028
NIA Mouse Gene Index	U004260
EC	2.7.10.2, 2.7.11.1
Consensus CDS Project	CCDS18124.1
International Mouse Knockout Project Status	Melk

Sequences

Length	Strain/Species
genomic	OTTMUSG00000006665	VEGA Gene Model | MGI Sequence Detail	63800	C57BL/6J
transcript	OTTMUST00000015242	VEGA | MGI Sequence Detail	2955	Not Applicable
polypeptide	OTTMUSP00000007045	VEGA | MGI Sequence Detail	643	Not Applicable

All sequences(56) RefSeq(2) UniProt(7)

Polymorphisms

PCR(1) : SNPs(298 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001772	Kinase associated domain 1 (KA1)
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR002290	Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
Protein Ontology	PR:000010319	maternal embryonic leucine zipper kinase

References

(Earliest) J:40042 Heyer BS, et al., New member of the Snf1/AMPK kinase family, Melk, is expressed in the mouse egg and preimplantation embryo. Mol Reprod Dev. 1997 Jun;47(2):148-56
(Latest) J:193001 Seong HA, et al., Murine protein serine-threonine kinase 38 activates p53 function through Ser15 phosphorylation. J Biol Chem. 2012 Jun 15;287(25):20797-810
All references(46)

Other accession IDs

MGD-MRK-35385, MGI:2140251