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Melk Gene Detail
Summary
  • Symbol
    Melk
  • Name
    maternal embryonic leucine zipper kinase
  • Synonyms
    mKIAA0175, MPK38
  • Feature Type
    protein coding gene
  • IDs
    MGI:106924
    NCBI Gene: 17279
  • Gene Overview
    MyGene.info: MELK
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr4:44300876-44364675 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      63800 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 23.46 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    MELK, maternal embryonic leucine zipper kinase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MELK, maternal embryonic leucine zipper kinase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HPK38
  • Links
    NCBI Gene ID: 9833
    neXtProt AC: NX_Q14680
    UniProt: Q14680

  • Chr Location
    9p13.2; chr9:36572862-36677683 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 32111
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MELK
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for an allele that produces a kinase-dead protein exhibit altered pancreatic regeneration following injury.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000006665 VEGA Gene Model | MGI Sequence Detail 63800 C57BL/6J ±  kb
    transcript OTTMUST00000015242 VEGA | MGI Sequence Detail 2955 Not Applicable  
    polypeptide OTTMUSP00000007045 VEGA | MGI Sequence Detail 643 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      466 from dbSNP Build 142
    • PCR
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 107
      cDNA 103
      Primer pair 3
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-35385, MGI:2140251
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 7
      Gene Ontology 9
      Phenotypes 7
    • Earliest
      J:40042 Heyer BS, et al., New member of the Snf1/AMPK kinase family, Melk, is expressed in the mouse egg and preimplantation embryo. Mol Reprod Dev. 1997 Jun;47(2):148-56
    • Latest
      J:228782 Chung CH, et al., Maternal embryonic leucine zipper kinase regulates pancreatic ductal, but not beta-cell, regeneration. Physiol Rep. 2014 Sep 1;2(9)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory