Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MBP
  • Mouse genes Mbp
  • Rat genes Mbp
  • Zfish genes mbpa,mbpb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mbp

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005516	calmodulin binding	MBP	IPI	UniProtKB:P62157	Human	PMID:19855925
Molecular Function	GO:0005516	calmodulin binding	Mbp	IPI	UniProtKB:P0DP23|UniProtKB:P0DP24|UniProtKB:P0DP25	Mouse	MGI:MGI:5883208|PMID:19855925
Molecular Function	GO:0002020	protease binding	Mbp	IPI	UniProtKB:Q05910	Mouse	MGI:MGI:2446968|PMID:12372841
Molecular Function	GO:0005515	protein binding	MBP	IPI	UniProtKB:Q9GZU7	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MBP	IPI	UniProtKB:Q9GZU7	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	Mbp	IPI	UniProtKB:Q62976	Rat	PMID:17610306|RGD:8554328
Molecular Function	GO:0019911	structural constituent of myelin sheath	Mbp	IMP		Rat	PMID:10212300|RGD:1358763
Cellular Component	GO:0071944	cell periphery	Mbp	IDA		Mouse	PMID:16723544
Cellular Component	GO:0042995	cell projection	Mbp	IDA		Mouse	PMID:16421295
Cellular Component	GO:0009986	cell surface	Mbp	IDA		Rat	PMID:21401967|RGD:13792533
Cellular Component	GO:0043218	compact myelin	Mbp	IDA		Mouse	PMID:12718855
Cellular Component	GO:0043218	compact myelin	Mbp	IDA		Rat	PMID:10537049|RGD:633193
Cellular Component	GO:0043218	compact myelin	Mbp	IDA		Rat	PMID:2462020|RGD:1358774
Cellular Component	GO:0033269	internode region of axon	Mbp	IDA		Mouse	PMID:16421295
Cellular Component	GO:0043209	myelin sheath	MBP	IDA		Human	PMID:19855925
Cellular Component	GO:0043209	myelin sheath	Mbp	IDA		Mouse	MGI:MGI:5883208|PMID:19855925
Cellular Component	GO:0043209	myelin sheath	Mbp	HDA		Mouse	MGI:MGI:3834050|PMID:17634366
Cellular Component	GO:0043209	myelin sheath	Mbp	IDA		Mouse	PMID:29034508
Cellular Component	GO:0043209	myelin sheath	Mbp	IDA		Mouse	PMID:16405874
Cellular Component	GO:0043209	myelin sheath	Mbp	IDA		Mouse	PMID:24101522
Cellular Component	GO:0043209	myelin sheath	Mbp	IDA		Mouse	PMID:20578039
Cellular Component	GO:0043209	myelin sheath	Mbp	IDA		Mouse	PMID:1694232
Cellular Component	GO:0043209	myelin sheath	Mbp	IDA		Mouse	PMID:16421295
Cellular Component	GO:0043209	myelin sheath	Mbp	IDA		Rat	PMID:17960831|RGD:10047364
Cellular Component	GO:0043209	myelin sheath	Mbp	IDA		Rat	PMID:19855925|RGD:12793026
Cellular Component	GO:0043209	myelin sheath	mbpa	IDA		Zfish	PMID:24040667
Cellular Component	GO:0043209	myelin sheath	mbpa	IDA		Zfish	PMID:19503091
Cellular Component	GO:0043209	myelin sheath	mbpb	IDA		Zfish	PMID:24040667
Cellular Component	GO:0043025	neuronal cell body	Mbp	IDA		Mouse	PMID:16421295
Cellular Component	GO:0005886	plasma membrane	mbpa	IDA		Zfish	PMID:24040667
Cellular Component	GO:0005886	plasma membrane	mbpb	IDA		Zfish	PMID:24040667
Cellular Component	GO:0032991	protein-containing complex	MBP	IDA		Human	PMID:19855925
Cellular Component	GO:0032991	protein-containing complex	Mbp	IDA		Mouse	MGI:MGI:5883208|PMID:19855925
Biological Process	GO:0007568	aging	Mbp	IEP		Rat	PMID:24026164|RGD:7327192
Biological Process	GO:0035633	maintenance of blood-brain barrier	MBP	IDA		Human	PMID:22524708
Biological Process	GO:0000165	MAPK cascade	MBP	IDA		Human	PMID:22524708
Biological Process	GO:0061024	membrane organization	Mbp	IDA		Mouse	PMID:20334434
Biological Process	GO:0042552	myelination	Mbp	IDA		Mouse	PMID:14614079
Biological Process	GO:0042552	myelination	Mbp	IMP		Rat	PMID:15869936|RGD:1358762
Biological Process	GO:0050771	negative regulation of axonogenesis	Mbp	IMP		Rat	PMID:12210134|RGD:1358766
Biological Process	GO:0034115	negative regulation of heterotypic cell-cell adhesion	MBP	IDA		Human	PMID:22524708
Biological Process	GO:2000343	positive regulation of chemokine (C-X-C motif) ligand 2 production	MBP	IDA		Human	PMID:22524708
Biological Process	GO:0032755	positive regulation of interleukin-6 production	MBP	IDA		Human	PMID:22524708
Biological Process	GO:1904685	positive regulation of metalloendopeptidase activity	MBP	IDA		Human	PMID:22524708
Biological Process	GO:0070542	response to fatty acid	Mbp	IEP		Rat	PMID:21892882|RGD:7349332
Biological Process	GO:0046689	response to mercury ion	Mbp	IEP		Rat	PMID:22835759|RGD:7327206
Biological Process	GO:0032570	response to progesterone	Mbp	IDA		Rat	PMID:12887683|RGD:7349335
Biological Process	GO:0009636	response to toxic substance	Mbp	IDA		Mouse	PMID:20578039
Biological Process	GO:0034612	response to tumor necrosis factor	Mbp	IEP		Rat	PMID:23735240|RGD:7327194
Biological Process	GO:0007605	sensory perception of sound	Mbp	IMP	MGI:MGI:3708458	Mouse	PMID:17329413
Biological Process	GO:0021762	substantia nigra development	MBP	HEP		Human	PMID:22926577

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern