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Mbp
Gene Detail
Symbol

Name
ID
Mbp
myelin basic protein
MGI:96925
STS
Synonyms
golli-mbp, Hmbpr
Feature Type
protein coding gene
Genetic Map
Chromosome 18
55.84 cM, cytoband E2-E4
Detailed Genetic Map ± 1 cM


Mapping data(42)
Sequence Map
Chr18:82475146-82585637 bp, + strand
From VEGA annotation of GRCm38

  110492 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1788  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Mbp

Human
homologs
Human Homolog MBP, myelin basic protein
NCBI Gene ID 4155
neXtProt AC  NX_P02686
Human Chr (Location)  18q23; chr18:76978833-77133708 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(4) Spontaneous(5) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele show altered myelination, oligodendrocytes, Ca2+ responses, and visual-evoked potentials. Spontaneous mutations cause dymyelination, tremors and ataxia, and may alter survival, susceptibility to seizures, viral infection and EAE, and hearing or vestibular function.
 
Phenotype Images(1)
Interactions
Mbp interacts with 301 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process membrane organization, myelination, ...
Component cell periphery, cell projection, ...
Function protease binding, structural constituent of myelin sheath
External Resources: FuncBase
Expression
Literature Summary: (146 records)
Data Summary: Results (245)    Tissues (81)    Images (56)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 29
RNA in situ 146
Western blot 32
RT-PCR 38
cDNA source data(32)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(86) Genomic(18) cDNA(37) Primer pair(11) Other(20)
Microarray probesets(8)
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016316 VEGA Gene Model | MGI Sequence Detail 110492 C57BL/6J ±  kb
transcript OTTMUST00000039208 VEGA | MGI Sequence Detail 2492 Not Applicable 
polypeptide OTTMUSP00000017514 VEGA | MGI Sequence Detail 250 Not Applicable 

For the selected sequences
All sequences(263) RefSeq(30) UniProt(23)
Polymorphisms
All PCR and RFLP(26) : PCR(4) RFLP(22) SNPs within 2kb(393 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000548 Myelin basic protein
Protein Ontology PR:000010228 myelin basic protein
References
(Earliest) J:46297 Biddle F, et al., The genetic analysis of the sensitivity of the CBA/J strain et al. Mouse News Lett. 1973;48:24
(Latest) J:214134 Lutz D, et al., Myelin basic protein cleaves cell adhesion molecule L1 and promotes neuritogenesis and cell survival. J Biol Chem. 2014 May 9;289(19):13503-18
All references(421)
Other
accession IDs
MGD-MRK-10746, MGD-MRK-12126, MGD-MRK-12253, MGD-MRK-14404, MGI:2147393, MGI:2147422

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory