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Mbp Gene Detail
Summary
  • Symbol
    Mbp
  • Name
    myelin basic protein
  • Synonyms
    golli-mbp, Hmbpr, jve
  • Feature Type
    protein coding gene
  • IDs
    MGI:96925
    NCBI Gene: 17196
  • Alliance
    genome feature page
  • Transcription Start Sites
    45 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:82493271-82603762 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 55.84 cM, cytoband E2-E4
  • Mapping Data
    42 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3454 from dbSNP Build 142
  • Strain Annotations
    28
  • PCR
    4
  • RFLP
    22
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96925
 protein coding gene Chr18:82492883-82603762 (+)
129S1/SvImJ ENSMUSG00200027672
 protein coding gene Chr18:79790921-79822167 (+)
A/J ENSMUSG00195004662
 protein coding gene Chr18:79880878-79912045 (+)
A/J ENSMUSGG00195055225
 protein coding gene Chr18:79823425-79837042 (+)
AKR/J ENSMUSGG00220054764
 protein coding gene Chr18:79746571-79760194 (+)
AKR/J ENSMUSG00220017074
 protein coding gene Chr18:79800402-79831570 (+)
BALB/cJ ENSMUSGG00180055376
 protein coding gene Chr18:80393768-80407385 (+)
BALB/cJ ENSMUSG00180013100
 protein coding gene Chr18:80447583-80478750 (+)
C3H/HeJ ENSMUSGG00175055086
 protein coding gene Chr18:79933963-79947583 (+)
C3H/HeJ ENSMUSG00175011726
 protein coding gene Chr18:79987774-80018941 (+)
C57BL/6NJ ENSMUSGG00215055216
 protein coding gene Chr18:79312912-79326529 (+)
C57BL/6NJ ENSMUSG00215019813
 protein coding gene Chr18:79366727-79397895 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022444
 protein coding gene Chr18:78620687-78731252 (+)
CAST/EiJ ENSTCUG00005026072
 protein coding gene Chr18:78898645-78929787 (+)
CBA/J ENSMUSGG00210054466
 protein coding gene Chr18:79884432-79898049 (+)
CBA/J ENSMUSG00210034078
 protein coding gene Chr18:79938240-79969411 (+)
DBA/2J ENSMUSGG00185057678
 protein coding gene Chr18:79789742-79803360 (+)
DBA/2J ENSMUSG00185010815
 protein coding gene Chr18:79843562-79874729 (+)
FVB/NJ ENSMUSGG00205054561
 protein coding gene Chr18:79197789-79211406 (+)
FVB/NJ ENSMUSG00205016329
 protein coding gene Chr18:79251615-79282782 (+)
JF1/MsJ ENSUMUG00000021180
 protein coding gene Chr18:79735540-79766608 (+)
LP/J ENSMUSG00230011513
 protein coding gene Chr18:81893140-81924378 (+)
NOD/ShiLtJ ENSMUSG00190020948
 protein coding gene Chr18:79668678-79699843 (+)
NOD/ShiLtJ ENSMUSGG00190054837
 protein coding gene Chr18:79614858-79628475 (+)
NZO/HlLtJ ENSMUSG00225033689
 protein coding gene Chr18:81768657-81799815 (+)
NZO/HlLtJ ENSMUSGG00225055350
 protein coding gene Chr18:81714948-81728565 (+)
PWK/PhJ ENSLUMG00010006393
 protein coding gene Chr18:80130493-80161546 (+)
SPRET/EiJ no annotation
WSB/EiJ ENSIUOG00005007413
 protein coding gene Chr18:79309106-79340360 (+)



Homology
more
  • Human Ortholog
    MBP, myelin basic protein
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MBP, myelin basic protein
  • Links
    NCBI Gene ID: 4155
    UniProt: P02686

  • Chr Location
    18q23; chr18:76978827-77133708 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human MBP associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    47 phenotypes from 5 alleles in 11 genetic backgrounds
    16 phenotypes from multigenic genotypes
    1 images
    182 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show altered myelination, oligodendrocytes, Ca2+ responses, and visual-evoked potentials. Spontaneous mutations cause dymyelination, tremors and ataxia, and may alter survival, susceptibility to seizures, viral infection and EAE, and hearing or vestibular function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    43
  • GO References
    21
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1193
  • Tissues
    152
  • cDNA Data
    37
  • Literature Summary
    300
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000041607 Ensembl Gene Model | MGI Sequence Detail 110492 C57BL/6J ±  kb
    transcript ENSMUST00000047865 Ensembl | MGI Sequence Detail 2492 Not Applicable  
    polypeptide ENSMUSP00000046185 Ensembl | MGI Sequence Detail 250 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 110
      Genomic 18
      cDNA 42
      Primer pair 22
      Other 28
      Antibodies 32

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-10746, MGD-MRK-12126, MGD-MRK-12253, MGD-MRK-14404, MGI:2147393, MGI:2147422, MGI:3708158
    References
    more
    • Summaries
      All 668
      Developmental Gene Expression 300
      Gene Ontology 21
      Phenotypes 182
    • Earliest
      J:5917 Doolittle DP, et al., Myelin deficient, a new neurological mutant in the mouse. J Hered. 1977 Sep-Oct;68(5):331-2
    • Latest
      J:390443 Chen H, et al., NSD2 Coordinates the Neurogenic-to-Gliogenic Transition via H3K36me2-Dependent Activation of the EGFR-ERK Pathway. Adv Sci (Weinh). 2026 Jul 27;:e76695
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory