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Mbp Gene Detail
Summary
  • Symbol
    Mbp
  • Name
    myelin basic protein
  • Synonyms
    golli-mbp, Hmbpr, jve
  • Feature Type
    protein coding gene
  • IDs
    MGI:96925
    NCBI Gene: 17196
  • Gene Overview
    MyGene.info: MBP
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr18:82475146-82585637 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      110492 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 55.84 cM, cytoband E2-E4
  • Mapping Data
    42 experiments
  • Sequence Tag
Homology
more
  • Human Ortholog
    MBP, myelin basic protein
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MBP, myelin basic protein
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 4155
    neXtProt AC: NX_P02686
    UniProt: P02686

  • Chr Location
    18q23; chr18:76978833-77133708 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 1788
    1 human;1 mouse;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MBP
  • Gene Tree
    Mbp
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    51 phenotypes from 6 alleles in 12 genetic backgrounds
    10 phenotypes from multigenic genotypes
    1 images
    153 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show altered myelination, oligodendrocytes, Ca2+ responses, and visual-evoked potentials. Spontaneous mutations cause dymyelination, tremors and ataxia, and may alter survival, susceptibility to seizures, viral infection and EAE, and hearing or vestibular function.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000016316 VEGA Gene Model | MGI Sequence Detail 110492 C57BL/6J ±  kb
    transcript OTTMUST00000039208 VEGA | MGI Sequence Detail 2492 Not Applicable  
    polypeptide OTTMUSP00000017514 VEGA | MGI Sequence Detail 250 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      389 from dbSNP Build 142
    • PCR
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 92
      Genomic 18
      cDNA 41
      Primer pair 12
      Other 21

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-10746, MGD-MRK-12126, MGD-MRK-12253, MGD-MRK-14404, MGI:2147393, MGI:2147422, MGI:3708158
    References
    more
    • Summaries
      All 510
      Developmental Gene Expression 193
      Gene Ontology 17
      Phenotypes 153
    • Earliest
      J:5917 Doolittle DP, et al., Myelin deficient, a new neurological mutant in the mouse. J Hered. 1977 Sep-Oct;68(5):331-2
    • Latest
      J:263977 Zhao C, et al., Dual Requirement of CHD8 for Chromatin Landscape Establishment and Histone Methyltransferase Recruitment to Promote CNS Myelination and Repair. Dev Cell. 2018 Jun 18;45(6):753-768.e8

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    10/16/2018
    MGI 6.12
    The Jackson Laboratory