Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MAP2K5
  • Mouse genes Map2k5
  • Rat genes Map2k5
  • Zfish genes map2k5
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Map2k5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	Map2k5	IDA		Rat	PMID:7499418|RGD:61658
Molecular Function	GO:0004708	MAP kinase kinase activity	Map2k5	IDA		Mouse	PMID:19654213
Molecular Function	GO:0005515	protein binding	MAP2K5	IPI	UniProtKB:Q99759	Human	PMID:14743216
Molecular Function	GO:0005515	protein binding	MAP2K5	IPI	UniProtKB:P62993	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	MAP2K5	IPI	UniProtKB:Q06413	Human	PMID:18588859
Molecular Function	GO:0005515	protein binding	MAP2K5	IPI	UniProtKB:Q13164	Human	PMID:18588859
Molecular Function	GO:0005515	protein binding	MAP2K5	IPI	UniProtKB:Q8N448	Human	PMID:21516116
Molecular Function	GO:0005515	protein binding	MAP2K5	IPI	UniProtKB:Q9Y2U5	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	MAP2K5	IPI	UniProtKB:P08238	Human	PMID:22939624
Molecular Function	GO:0005515	protein binding	MAP2K5	IPI	UniProtKB:Q99759	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	MAP2K5	IPI	UniProtKB:Q13164	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	MAP2K5	IPI	UniProtKB:Q9Y2U5	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	MAP2K5	IPI	UniProtKB:Q8N448	Human	PMID:29892012
Molecular Function	GO:0005515	protein binding	MAP2K5	IPI	UniProtKB:Q8N448	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	MAP2K5	IPI	UniProtKB:P08238	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	MAP2K5	IPI	UniProtKB:Q13501	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	MAP2K5	IPI	UniProtKB:Q9Y2U5	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	MAP2K5	IPI	UniProtKB:Q13164	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MAP2K5	IPI	UniProtKB:Q13501	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MAP2K5	IPI	UniProtKB:Q3SXR2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MAP2K5	IPI	UniProtKB:Q6ZNG0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MAP2K5	IPI	UniProtKB:Q96NT3-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MAP2K5	IPI	UniProtKB:Q99471	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MAP2K5	IPI	UniProtKB:Q9BUY5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MAP2K5	IPI	UniProtKB:Q9H596	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MAP2K5	IPI	UniProtKB:P08238	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	MAP2K5	IPI	UniProtKB:Q13164	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	MAP2K5	IPI	UniProtKB:Q99759	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	MAP2K5	IPI	UniProtKB:Q9Y2U5	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	MAP2K5	IPI	UniProtKB:Q13164	Human	PMID:7759517
Molecular Function	GO:0005515	protein binding	Map2k5	IPI	UniProtKB:Q61083|UniProtKB:Q61084	Mouse	MGI:MGI:2675918|PMID:12912994
Molecular Function	GO:0005515	protein binding	Map2k5	IPI	UniProtKB:P28656|UniProtKB:Q61084|UniProtKB:Q64337	Mouse	MGI:MGI:3688344|PMID:15102471
Molecular Function	GO:0004672	protein kinase activity	Map2k5	IDA		Rat	PMID:7499418|RGD:61658
Molecular Function	GO:0043539	protein serine/threonine kinase activator activity	Map2k5	IDA		Mouse	PMID:19654213
Cellular Component	GO:0005829	cytosol	Map2k5	IDA		Rat	PMID:7499418|RGD:61658
Cellular Component	GO:0005634	nucleus	Map2k5	IDA		Rat	PMID:15075238|RGD:1582267
Cellular Component	GO:0005819	spindle	Map2k5	IDA		Mouse	PMID:15509711
Biological Process	GO:0007420	brain development	map2k5	IMP	ZFIN:ZDB-MRPHLNO-141229-4	Zfish	PMID:24995868
Biological Process	GO:0071363	cellular response to growth factor stimulus	Map2k5	IMP		Rat	PMID:20551324|RGD:8553940
Biological Process	GO:0070375	ERK5 cascade	Map2k5	IMP		Rat	PMID:15631999|RGD:1582263
Biological Process	GO:0007507	heart development	Map2k5	IMP	MGI:MGI:3526901	Mouse	PMID:15601854
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	Map2k5	IDA		Mouse	PMID:19654213
Biological Process	GO:0000165	MAPK cascade	Map2k5	IMP	MGI:MGI:3526901	Mouse	PMID:15601854
Biological Process	GO:0090051	negative regulation of cell migration involved in sprouting angiogenesis	Map2k5	IMP		Rat	PMID:20551324|RGD:8553940
Biological Process	GO:2000342	negative regulation of chemokine (C-X-C motif) ligand 2 production	Map2k5	IMP		Rat	PMID:20551324|RGD:8553940
Biological Process	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	Map2k5	IMP		Rat	PMID:20551324|RGD:8553940
Biological Process	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	Map2k5	IMP		Rat	PMID:20551324|RGD:8553940
Biological Process	GO:0034115	negative regulation of heterotypic cell-cell adhesion	Map2k5	IMP		Rat	PMID:20551324|RGD:8553940
Biological Process	GO:0032717	negative regulation of interleukin-8 production	Map2k5	IMP		Rat	PMID:20551324|RGD:8553940
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	Map2k5	IMP		Rat	PMID:20551324|RGD:8553940
Biological Process	GO:0060761	negative regulation of response to cytokine stimulus	Map2k5	IMP		Rat	PMID:20551324|RGD:8553940
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Map2k5	IMP		Rat	PMID:20551324|RGD:8553940
Biological Process	GO:0030307	positive regulation of cell growth	Map2k5	IMP		Rat	PMID:15623435|RGD:1582264
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	Map2k5	IDA		Rat	PMID:15631999|RGD:1582263
Biological Process	GO:0043406	positive regulation of MAP kinase activity	Map2k5	IMP		Rat	PMID:20551324|RGD:8553940
Biological Process	GO:0051247	positive regulation of protein metabolic process	Map2k5	IMP		Rat	PMID:20551324|RGD:8553940
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Map2k5	IMP		Rat	PMID:20551324|RGD:8553940
Biological Process	GO:0006468	protein phosphorylation	Map2k5	IDA		Rat	PMID:7499418|RGD:61658

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern