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Map2k5
Gene Detail
Symbol

Name
ID
Map2k5
mitogen-activated protein kinase kinase 5
MGI:1346345
Synonyms
MEK5
Feature Type
protein coding gene
Genetic Map
Chromosome 9
33.96 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:63163769-63377902 bp, - strand
From Ensembl annotation of GRCm38

  214134 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:115933  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Map2k5

Human
homologs
Human Homolog MAP2K5, mitogen-activated protein kinase kinase 5
NCBI Gene ID 5607
neXtProt AC  NX_Q13163
Human Synonyms  HsT17454, MAPKK5, MEK5, PRKMK5
Human Chr (Location)  15q23; chr15:67542683-67807117 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(6) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutants die at E10.5 and exhibit abnormal cardiac development and a decrease in proliferation and an increase in apoptosis in the heart, head, and dorsal regions of the embryo.
 
Interactions
Map2k5 interacts with 56 markers (Mir19a, Mir93, Mir130a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (38 annotations)
Process activation of MAPK activity, cellular response to growth factor stimulus, ...
Component cytoplasm, cytosol, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (30)    Tissues (21)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 24
RT-PCR 4
cDNA source data(43)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(45) cDNA(44) Primer pair(1)
Microarray probesets(7)
Other database
links
Ensembl Gene ModelENSMUSG00000058444 (Evidence)
Entrez Gene23938 (Evidence)
UniGene325746
DFCITC1593296, TC1579059, TC1593402, TC1595375
DoTSDT.490888, DT.101181067, DT.91447555, DT.91305644, DT.97341450, DT.94336441
NIA Mouse Gene IndexU030985
EC2.7.12.2
PDB1WI0
Consensus CDS ProjectCCDS23269.1
International Mouse Knockout Project StatusMap2k5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000058444 Ensembl Gene Model | MGI Sequence Detail 214134 C57BL/6J ±  kb
transcript ENSMUST00000034920 Ensembl | MGI Sequence Detail 2309 Not Applicable 
polypeptide ENSMUSP00000034920 Ensembl | MGI Sequence Detail 448 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(16) UniProt(5)
Polymorphisms
SNPs within 2kb(646 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000270 Phox/Bem1p
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000010127 dual specificity mitogen-activated protein kinase kinase 5
References
(Earliest) J:57565 Kamakura S, et al., Activation of the protein kinase ERK5/BMK1 by receptor tyrosine kinases. Identification and characterization of a signaling pathway to the nucleus. J Biol Chem. 1999 Sep 10;274(37):26563-71
(Latest) J:183463 Zou J, et al., Targeted deletion of ERK5 MAP kinase in the developing nervous system impairs development of GABAergic interneurons in the main olfactory bulb and behavioral discrimination between structurally similar odorants. J Neurosci. 2012 Mar 21;32(12):4118-32
All references(54)
Other
accession IDs
MGI:2143021, MGI:2143042

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/23/2014
MGI 5.20
The Jackson Laboratory