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Map2k5 Gene Detail
Summary
  • Symbol
    Map2k5
  • Name
    mitogen-activated protein kinase kinase 5
  • Synonyms
    MEK5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346345
    NCBI Gene: 23938
  • Gene Overview
    MyGene.info: MAP2K5
Location & Maps
more
  • Sequence Map
    Chr9:63163769-63377902 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      214134 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 33.96 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    MAP2K5, mitogen-activated protein kinase kinase 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MAP2K5, mitogen-activated protein kinase kinase 5
    Orthology source: HomoloGene
  • Synonyms
    HsT17454, MAPKK5, MEK5, PRKMK5
  • Links
    NCBI Gene ID: 5607
    neXtProt AC: NX_Q13163

  • Chr Location
    15q23; chr15:67542606-67807117 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (other)
    1
  • Gene trapped
    6
  • Targeted
    4
  • Genomic Mutations
    1 involving Map2k5
  • Incidental Mutations
Homozygous mutants die at E10.5 and exhibit abnormal cardiac development and a decrease in proliferation and an increase in apoptosis in the heart, head, and dorsal regions of the embryo.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000058444 Ensembl Gene Model | MGI Sequence Detail 214134 C57BL/6J ±  kb
transcript ENSMUST00000034920 Ensembl | MGI Sequence Detail 2309 Not Applicable  
polypeptide ENSMUSP00000034920 Ensembl | MGI Sequence Detail 448 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    642 from dbSNP Build 142
Protein
Information
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Molecular
Reagents
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  • All nucleic 45
    cDNA 44
    Primer pair 1

    Microarray probesets 7
Other
Accession IDs
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MGI:2143021, MGI:2143042
References
more
  • Summaries
    All 51
    Developmental Gene Expression 7
    Gene Ontology 7
    Phenotypes 13
  • Earliest
    J:57565 Kamakura S, et al., Activation of the protein kinase ERK5/BMK1 by receptor tyrosine kinases. Identification and characterization of a signaling pathway to the nucleus. J Biol Chem. 1999 Sep 10;274(37):26563-71
  • Latest
    J:222244 Wang W, et al., Inducible Activation of ERK5 MAP Kinase Enhances Adult Neurogenesis in the Olfactory Bulb and Improves Olfactory Function. J Neurosci. 2015 May 20;35(20):7833-49

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory