About   Help   FAQ
Map2k5
Gene Detail
Symbol

Name
ID
Map2k5
mitogen-activated protein kinase kinase 5
MGI:1346345
Synonyms
MEK5
Feature Type
protein coding gene
Genetic Map
Chromosome 9
33.96 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:63163769-63377902 bp, - strand
From Ensembl annotation of GRCm38

  214134 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:115933  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MAP2K5
Gene Tree: Map2k5

Human
homologs
MAP2K5, mitogen-activated protein kinase kinase 5
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5607
neXtProt AC: NX_Q13163

Human Synonyms: HsT17454, MAPKK5, MEK5, PRKMK5

Human Chr (Location): 15q23; chr15:67542606-67807117 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(6) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutants die at E10.5 and exhibit abnormal cardiac development and a decrease in proliferation and an increase in apoptosis in the heart, head, and dorsal regions of the embryo.
 
Interactions
Map2k5 interacts with 56 markers (Mir19a, Mir93, Mir130a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (38 annotations)
Process activation of MAPK activity, cellular response to growth factor stimulus, ...
Component cytoplasm, cytosol, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (30)    Tissues (21)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 24
RT-PCR 4
cDNA source data(43)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase map2k5    NEW 
Molecular
reagents
All nucleic(45) cDNA(44) Primer pair(1)
Microarray probesets(7)
Other database
links
Ensembl Gene Model ENSMUSG00000058444 (Evidence)
Entrez Gene 23938 (Evidence)
UniGene 325746
DFCI TC1579059, TC1593296, TC1593402, TC1595375
DoTS DT.101181067, DT.490888, DT.91305644, DT.91447555, DT.94336441, DT.97341450
NIA Mouse Gene Index U030985
EC 2.7.12.2
PDB 1WI0
Consensus CDS Project CCDS23269.1
International Mouse Phenotyping Consortium Status Map2k5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000058444 Ensembl Gene Model | MGI Sequence Detail 214134 C57BL/6J ±  kb
transcript ENSMUST00000034920 Ensembl | MGI Sequence Detail 2309 Not Applicable 
polypeptide ENSMUSP00000034920 Ensembl | MGI Sequence Detail 448 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(10) UniProt(3)
Polymorphisms
SNPs within 2kb(646 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000270 PB1 domain
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000010127 dual specificity mitogen-activated protein kinase kinase 5
References
(Earliest) J:57565 Kamakura S, et al., Activation of the protein kinase ERK5/BMK1 by receptor tyrosine kinases. Identification and characterization of a signaling pathway to the nucleus. J Biol Chem. 1999 Sep 10;274(37):26563-71
(Latest) J:222244 Wang W, et al., Inducible Activation of ERK5 MAP Kinase Enhances Adult Neurogenesis in the Olfactory Bulb and Improves Olfactory Function. J Neurosci. 2015 May 20;35(20):7833-49
All references(54)
Other
accession IDs
MGI:2143021, MGI:2143042

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/25/2015
MGI 6.0
The Jackson Laboratory