Map2k5 MGI Mouse Gene Detail - MGI:1346345 - mitogen-activated protein kinase kinase 5

Symbol

Map2k5
Name

mitogen-activated protein kinase kinase 5
Synonyms

MEK5

Feature Type

protein coding gene
IDs

MGI:1346345
NCBI Gene: 23938
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr9:63071050-63285184 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 33.96 cM
Mapping Data

2 experiments

SNPs within 2kb

642 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1346345	protein coding gene	Chr9:63071050-63288964 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0034928	protein coding gene	Chr9:62753986-62971044 (-)
A/J	MGP_AJ_G0034908	protein coding gene	Chr9:60668284-60885094 (-)
AKR/J	MGP_AKRJ_G0034838	protein coding gene	Chr9:62083159-62301141 (-)
BALB/cJ	MGP_BALBcJ_G0034901	protein coding gene	Chr9:60397948-60612132 (-)
C3H/HeJ	MGP_C3HHeJ_G0034611	protein coding gene	Chr9:62596351-62814608 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0035420	protein coding gene	Chr9:64484599-64703424 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032331	protein coding gene	Chr9:60323412-60542493 (-)
CAST/EiJ	MGP_CASTEiJ_G0033932	protein coding gene	Chr9:62745987-62962318 (-)
CBA/J	MGP_CBAJ_G0034582	protein coding gene	Chr9:66699533-66928310 (-)
DBA/2J	MGP_DBA2J_G0034741	protein coding gene	Chr9:60458379-60673398 (-)
FVB/NJ	MGP_FVBNJ_G0034683	protein coding gene	Chr9:59755772-59970636 (-)
LP/J	MGP_LPJ_G0034824	protein coding gene	Chr9:63034944-63255863 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034726	protein coding gene	Chr9:68029664-68248081 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035442	protein coding gene	Chr9:62167714-62386938 (-)
PWK/PhJ	MGP_PWKPhJ_G0033636	protein coding gene	Chr9:60593796-60812144 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0033470	protein coding gene	Chr9:62444741-62663187 (-)
WSB/EiJ	MGP_WSBEiJ_G0034045	protein coding gene	Chr9:62075560-62292275 (-)

Human Ortholog

MAP2K5, mitogen-activated protein kinase kinase 5

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MAP2K5, mitogen-activated protein kinase kinase 5
Synonyms

HsT17454, MAPKK5, MEK5, PRKMK5
Links

HGNC:6845

NCBI Gene ID: 5607

neXtProt AC: NX_Q13163

UniProt: Q13163
Chr Location

15q23; chr15:67542703-67807117 (+) GRCh38

MGI Vertebrate Homology

Map2k5 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MAP2K5
Gene Tree

Map2k5

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Phenotype Summary

11 phenotypes from 1 allele in 1 genetic background
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

6
Targeted

4
Genomic Mutations

1 involving Map2k5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

38 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutants die at E10.5 and exhibit abnormal cardiac development and a decrease in proliferation and an increase in apoptosis in the heart, head, and dorsal regions of the embryo.

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All GO Annotations

36
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

741
Tissues

26
cDNA Data

43
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase map2k5

ZFIN map2k5

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All Sequences

61
RefSeq

20
UniProt

3
CCDS

CCDS23269.1

Ensembl

ENSMUSG00000058444 (Evidence)
NCBI Gene

23938

			Length	Strain/Species	Flank
genomic	ENSMUSG00000058444	Ensembl Gene Model \| MGI Sequence Detail	214135	C57BL/6J	± kb
transcript	ENSMUST00000034920	Ensembl \| MGI Sequence Detail	2310	Not Applicable
polypeptide	ENSMUSP00000034920	Ensembl \| MGI Sequence Detail	448	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000010127 dual specificity mitogen-activated protein kinase kinase 5

(term hierarchy)
PDB

1WI0
EC

2.7.12.2
InterPro Domains

IPR034851 Dual specificity mitogen-activated protein kinase kinase 5, PB1 domain

IPR000270 PB1 domain

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

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All nucleic 47

cDNA 45

Primer pair 2

Microarray probesets 7

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MGI:2143021, MGI:2143042

Summaries

All 67

Developmental Gene Expression 9

Gene Ontology 11

Phenotypes 15
Earliest

J:57565 Kamakura S, et al., Activation of the protein kinase ERK5/BMK1 by receptor tyrosine kinases. Identification and characterization of a signaling pathway to the nucleus. J Biol Chem. 1999 Sep 10;274(37):26563-71
Latest

J:339061 Tsitsikov EN, et al., TRAF7 is an essential regulator of blood vessel integrity during mouse embryonic and neonatal development. iScience. 2023 Aug 18;26(8):107474

TSS for Map2k5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr90092	Chr9:63285242-63285262 (-)	-68 bp
Tssr90091	Chr9:63285117-63285196 (-)	27 bp
Tssr90090	Chr9:63285096-63285111 (-)	80 bp
Tssr90089	Chr9:63284906-63285048 (-)	207 bp
Tssr90088	Chr9:63230071-63230096 (-)	55,100 bp
Tssr90087	Chr9:63188542-63188553 (-)	96,636 bp
Tssr90086	Chr9:63188506-63188522 (-)	96,670 bp
Tssr90085	Chr9:63130429-63130445 (-)	154,747 bp
Tssr90084	Chr9:63104641-63104677 (-)	180,525 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23