Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MAFA
  • Mouse genes Mafa
  • Rat genes Mafa
  • Zfish genes mafaa
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mafa

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	MAFA	IDA		Human	PMID:12368292
Molecular Function	GO:0003677	DNA binding	Mafa	IDA		Mouse	PMID:12368292
Molecular Function	GO:0003677	DNA binding	Mafa	IDA		Mouse	PMID:12917329
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Mafa	IDA		Mouse	MGI:MGI:2447494|PMID:12368292
Molecular Function	GO:0005515	protein binding	Mafa	IPI	RGD:1305902	Rat	PMID:18042454|RGD:9590276
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Mafa	IDA		Mouse	MGI:MGI:2447494|PMID:12368292
Molecular Function	GO:0043565	sequence-specific DNA binding	mafaa	IDA		Zfish	PMID:11134968
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	MAFA	IDA		Human	PMID:28473536
Cellular Component	GO:0005634	nucleus	MAFA	IDA		Human	PMID:12368292
Cellular Component	GO:0005634	nucleus	Mafa	IDA		Mouse	PMID:12368292
Cellular Component	GO:0005634	nucleus	Mafa	IDA		Mouse	PMID:17928203
Cellular Component	GO:0005634	nucleus	Mafa	IDA		Mouse	PMID:12917329
Cellular Component	GO:0005634	nucleus	Mafa	IDA		Rat	PMID:18042454|RGD:9590276
Biological Process	GO:0030073	insulin secretion	MAFA	IDA		Human	PMID:17941991
Biological Process	GO:0007263	nitric oxide mediated signal transduction	MAFA	IDA		Human	PMID:17941991
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Mafa	IDA		Mouse	PMID:12368292
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Mafa	IDA		Mouse	MGI:MGI:2447494|PMID:12368292
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Mafa	IDA		Mouse	PMID:16890542
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Mafa	IDA		Mouse	PMID:12917329
Biological Process	GO:0009749	response to glucose	MAFA	IDA		Human	PMID:12368292

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern