Mafa
Gene Detail

Symbol Name ID

Mafa v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A (avian) MGI:2673307

Synonyms

RIPE3b1

Feature Type

protein coding gene

Genetic Map

Chromosome 15

34.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr15:75746843-75747922 bp, - strand From NCBI annotation of GRCm38   1080 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:65867  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: maf transforming protein
Gene Tree: Mafa

Human homologs

Human Homolog		MAFA, v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)
NCBI Gene ID		389692
neXtProt AC		NX_Q8NHW3
Human Synonyms		hMafA, RIPE3b1
Human Chr (Location)		8q24.3; chr8:144510230-144512602 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Homozygous mutant mice exhibit glucose intolerance and develop diabetes mellitus. Glucose-stimulated insulin secretion is severely impaired and mutant mice display pancreatic islet abnormalities as they age.

 
Human Diseases Modeled Using Mouse Mafa (2)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	insulin secretion, nitric oxide mediated signal transduction, ...
Component	nucleus
Function	DNA binding, sequence-specific DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (40 records)
Data Summary: Results (65)    Tissues (28)    Images (3)
Theiler Stages: 11, 13, 16, 17, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	8
RNA in situ	11
In situ reporter (knock in)	40
RT-PCR	6

cDNA source data(9)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(12) cDNA(9) Primer pair(2) Other(1)
Microarray probesets(2)

Other database links

Ensembl Gene Model	ENSMUSG00000047591 (Evidence)
Entrez Gene	378435 (Evidence)
UniGene	25089
DFCI	TC1637964, TC1720001
DoTS	DT.101309325, DT.40136011
NIA Mouse Gene Index	U118621
Consensus CDS Project	CCDS27549.1
International Mouse Knockout Project Status	Mafa

Sequences

Length	Strain/Species
genomic	378435	NCBI Gene Model | MGI Sequence Detail	1080	C57BL/6J
transcript	NM_194350	RefSeq | MGI Sequence Detail	1080	Not Specified
polypeptide	Q8CF90	UniProt | EBI | MGI Sequence Detail	359	Not Applicable

All sequences(15) RefSeq(2) UniProt(1)

Protein-related information

Resource	ID	Description
InterPro	IPR004827	Basic-leucine zipper domain
InterPro	IPR004826	Basic leucine zipper domain, Maf-type
InterPro	IPR008917	Eukaryotic transcription factor, Skn-1-like, DNA-binding
InterPro	IPR013592	Maf transcription factor, N-terminal
InterPro	IPR024874	Transcription factor Maf
Protein Ontology	PR:000010047	transcription factor MafA

Graphical View of Protein Domain Structure

References

(Earliest) J:80902 Kataoka K, et al., MafA is a glucose-regulated and pancreatic beta-cell-specific transcriptional activator for the insulin gene. J Biol Chem. 2002 Dec 20;277(51):49903-10
(Latest) J:192831 Lin JC, et al., RBM4 promotes pancreas cell differentiation and insulin expression. Mol Cell Biol. 2013 Jan;33(2):319-27
All references(72)