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Mafa
Gene Detail
 Symbol
Name
ID
Mafa
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A (avian)
MGI:2673307
Synonyms RIPE3b1
Feature Type protein coding gene
Genetic Map
Chromosome 15
34.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:75746843-75747922 bp, - strand
From NCBI annotation of GRCm38

  1080 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:65867  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: maf transforming protein
Gene Tree: Mafa

Human
homologs
Human Homolog MAFA, v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A
NCBI Gene ID 389692
neXtProt AC  NX_Q8NHW3
Human Synonyms  hMafA, RIPE3b1
Human Chr (Location)  8q24.3; chr8:143428060-143430432 (-)  GRCh38
Alleles
and
phenotypes
All alleles(5) : Targeted(5)
 
Homozygous mutant mice exhibit glucose intolerance and develop diabetes mellitus. Glucose-stimulated insulin secretion is severely impaired and mutant mice display pancreatic islet abnormalities as they age.
 
Human Diseases Modeled Using Mouse Mafa (2)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process insulin secretion, nitric oxide mediated signal transduction, ...
Component nucleus
Function DNA binding, sequence-specific DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (46 records)
Data Summary: Results (65)    Tissues (28)    Images (3)
Theiler Stages: 11, 13, 16, 17, 19, 20, 21, 22, 23, 24, 26, 28
Assay TypeResults
Immunohistochemistry 8
RNA in situ 11
In situ reporter (knock in) 40
RT-PCR 6
cDNA source data(9)
External Resources: GEO   ArrayExpress
Molecular
reagents
All nucleic(12) cDNA(9) Primer pair(2) Other(1)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000047591 (Evidence)
Entrez Gene378435 (Evidence)
UniGene25089
DFCITC1637964, TC1720001
DoTSDT.101309325, DT.40136011
NIA Mouse Gene IndexU118621
Consensus CDS ProjectCCDS27549.1
International Mouse Knockout Project StatusMafa
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 378435 NCBI Gene Model | MGI Sequence Detail 1080 C57BL/6J ±  kb
transcript NM_194350 RefSeq | MGI Sequence Detail 1080 Not Specified 
polypeptide Q8CF90 UniProt | EBI | MGI Sequence Detail 359 Not Applicable 

For the selected sequences
All sequences(15) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(6 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004827 Basic-leucine zipper domain
InterPro IPR004826 Basic leucine zipper domain, Maf-type
InterPro IPR008917 Eukaryotic transcription factor, Skn-1-like, DNA-binding
InterPro IPR013592 Maf transcription factor, N-terminal
InterPro IPR024874 Transcription factor Maf
Protein Ontology PR:000010047 transcription factor MafA
Graphical View of Protein Domain Structure
References (Earliest) J:80902 Kataoka K, et al., MafA is a glucose-regulated and pancreatic beta-cell-specific transcriptional activator for the insulin gene. J Biol Chem. 2002 Dec 20;277(51):49903-10
(Latest) J:208336 Kesavan G, et al., Cdc42/N-WASP signaling links actin dynamics to pancreatic beta cell delamination and differentiation. Development. 2014 Feb;141(3):685-96
All references(78)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory