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Mafa
Gene Detail
Symbol

Name
ID
Mafa
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A (avian)
MGI:2673307
Synonyms
RIPE3b1
Feature Type
protein coding gene
Genetic Map
Chromosome 15
34.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:75746843-75747922 bp, - strand
From NCBI annotation of GRCm38

  1080 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:65867  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MAFA
Protein SuperFamily: maf transforming protein
Gene Tree: Mafa

Human
homologs
MAFA, v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 389692
neXtProt AC: NX_Q8NHW3

Human Synonyms: hMafA, RIPE3b1

Human Chr (Location): 8q24.3; chr8:143428060-143430432 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Radiation induced(1) Targeted(5)
Genomic Mutations involving Mafa (1)
 
Homozygous mutant mice exhibit glucose intolerance and develop diabetes mellitus. Glucose-stimulated insulin secretion is severely impaired and mutant mice display pancreatic islet abnormalities as they age.
 
Human Diseases Modeled in Mice Using Mafa (2)    Mutations Annotated to Human Diseases (1)    Phenotype Images(2)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (53 records)
Data Summary: Results (75)    Tissues (29)    Images (20)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 16
RNA in situ 11
In situ reporter (knock in) 40
RT-PCR 8
cDNA source data(9)
Other mouse links: GEO   Expression Atlas
Other vertebrate links: ZFIN mafa    NEW 
Molecular
reagents
All nucleic(13) cDNA(9) Primer pair(3) Other(1)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000047591 (Evidence)
Entrez Gene 378435 (Evidence)
UniGene 25089
DFCI TC1720001, TC1637964
DoTS DT.40136011, DT.101309325
NIA Mouse Gene Index U118621
Consensus CDS Project CCDS27549.1
International Mouse Phenotyping Consortium Status Mafa
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 378435 NCBI Gene Model | MGI Sequence Detail 1080 C57BL/6J ±  kb
transcript NM_194350 RefSeq | MGI Sequence Detail 1080 Not Specified 
polypeptide Q8CF90 UniProt | EBI | MGI Sequence Detail 359 Not Applicable 

For the selected sequences
All sequences(15) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(6 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004827 Basic-leucine zipper domain
InterPro IPR004826 Basic leucine zipper domain, Maf-type
InterPro IPR008917 Eukaryotic transcription factor, Skn-1-like, DNA-binding
InterPro IPR013592 Maf transcription factor, N-terminal
InterPro IPR024874 Transcription factor Maf
Protein Ontology PR:000010047 transcription factor MafA
Graphical View of Protein Domain Structure
References
(Earliest) J:80902 Kataoka K, et al., MafA is a glucose-regulated and pancreatic beta-cell-specific transcriptional activator for the insulin gene. J Biol Chem. 2002 Dec 20;277(51):49903-10
(Latest) J:219768 Nishimura W, et al., MafA is critical for maintenance of the mature beta cell phenotype in mice. Diabetologia. 2015 Mar;58(3):566-74
All references(88)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory