Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MADD
  • Mouse genes Madd
  • Rat genes Madd
  • Zfish genes madd
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Madd

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	MADD	IDA		Human	PMID:20937701
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	MADD	IMP		Human	PMID:9115275
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	Madd	IDA		Rat	PMID:9224661|RGD:9588648
Molecular Function	GO:0005515	protein binding	MADD	IPI	UniProtKB:Q16849	Human	PMID:16273344
Molecular Function	GO:0005515	protein binding	MADD	IPI	UniProtKB:Q9NUX5	Human	PMID:21044950
Molecular Function	GO:0005515	protein binding	MADD	IPI	UniProtKB:P19438	Human	PMID:9115275
Molecular Function	GO:0005515	protein binding	Madd	IPI	RGD:619836	Rat	PMID:12786944|RGD:1354686
Cellular Component	GO:0030424	axon	Madd	IDA		Mouse	MGI:MGI:6189386|PMID:18849981
Cellular Component	GO:1904115	axon cytoplasm	Madd	IDA		Mouse	MGI:MGI:6189386|PMID:18849981
Cellular Component	GO:0005829	cytosol	MADD	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	Madd	IDA		Rat	PMID:23702376|RGD:9588639
Cellular Component	GO:0016020	membrane	MADD	IDA		Human	PMID:8988362
Cellular Component	GO:0005634	nucleus	Madd	IDA		Rat	PMID:12625816|RGD:9588641
Cellular Component	GO:0005886	plasma membrane	MADD	IDA		Human	GO_REF:0000052
Cellular Component	GO:0045202	synapse	Madd	IDA		Rat	PMID:9852129|RGD:9588649
Cellular Component	GO:0008021	synaptic vesicle	Madd	IDA		Rat	PMID:12786944|RGD:1354686
Biological Process	GO:0048490	anterograde synaptic vesicle transport	Madd	IDA		Mouse	PMID:18849981
Biological Process	GO:0048490	anterograde synaptic vesicle transport	Madd	IMP		Mouse	PMID:18849981
Biological Process	GO:0097194	execution phase of apoptosis	MADD	IMP		Human	PMID:14735464
Biological Process	GO:0097194	execution phase of apoptosis	Madd	IMP		Mouse	MGI:MGI:3700423|PMID:14735464
Biological Process	GO:2001234	negative regulation of apoptotic signaling pathway	Madd	IMP		Mouse	PMID:14735464
Biological Process	GO:0060125	negative regulation of growth hormone secretion	Madd	IDA		Rat	PMID:16473592|RGD:9588640
Biological Process	GO:1902277	negative regulation of pancreatic amylase secretion	Madd	IMP		Rat	PMID:23702376|RGD:9588639
Biological Process	GO:0043410	positive regulation of MAPK cascade	MADD	IMP		Human	PMID:9115275
Biological Process	GO:0042981	regulation of apoptotic process	MADD	IMP		Human	PMID:11577081
Biological Process	GO:0051726	regulation of cell cycle	MADD	IMP		Human	PMID:14735464
Biological Process	GO:0051726	regulation of cell cycle	Madd	IMP		Mouse	MGI:MGI:3700423|PMID:14735464
Biological Process	GO:2001236	regulation of extrinsic apoptotic signaling pathway	MADD	IDA		Human	PMID:11577081
Biological Process	GO:1902041	regulation of extrinsic apoptotic signaling pathway via death domain receptors	MADD	IMP		Human	PMID:9115275
Biological Process	GO:0032483	regulation of Rab protein signal transduction	MADD	IDA		Human	PMID:20937701

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern