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Gene Detail
MAP-kinase activating death domain
Synonyms 9630059K23Rik, mKIAA0358, Rab3 GEP
Feature Type protein coding gene
Genetic Map
Chromosome 2
50.46 cM
Detailed Genetic Map ± 1 cM

Mapping data(1)
Sequence Map
Chr2:91137360-91183837 bp, - strand
From VEGA annotation of GRCm38

  46478 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:14249  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: MAP kinase-activating death domain protein
Gene Tree: Madd

Human Homolog MADD, MAP-kinase activating death domain
NCBI Gene ID 8567
neXtProt AC  NX_Q8WXG6
Human Synonyms  DENN, IG20, RAB3GEP
Human Chr (Location)  11p11.2; chr11:47269376-47330031 (+)  GRCh38
alleles, and
All mutations/alleles(3) : Targeted(3)
Genomic Mutations involving Madd (2)
Incidental mutations (data from Mutagenetix , APF )
Mice homozygous for a knock-out allele die shortly after birth due to respiratory failure, are hyporesponsive to tactile stimuli, and exhibit defects in neurotransmitter release with impaired synaptic vesicle trafficking and depletion of synaptic vesicles at the neuromuscular junction.
Madd interacts with 174 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
All GO classifications: (21 annotations)
Process activation of MAPK activity, apoptotic process, ...
Component cytoplasm, integral component of membrane, ...
Function guanyl-nucleotide exchange factor activity, Rab guanyl-nucleotide exchange factor activity
External Resources: FuncBase
Literature Summary: (4 records)
Data Summary: Results (105)    Tissues (18)    Images (24)
Theiler Stages: 22, 23, 24
Assay TypeResults
RNA in situ 105
cDNA source data(102)
External Resources: Allen Institute   GEO   Expression Atlas
All nucleic(103) cDNA(103)
Microarray probesets(5)
Other database
VEGA Gene ModelOTTMUSG00000014395 (Evidence)
Ensembl Gene ModelENSMUSG00000040687 (Evidence)
Entrez Gene228355 (Evidence)
DFCITC1577745, TC1585259, TC1594079, TC1596258, TC1607430, TC1635456
DoTSDT.485353, DT.101172669, DT.101335537, DT.101401635, DT.101401639, DT.101401640, DT.101401644, DT.101401645, DT.101401646, DT.91414820, DT.91576593, DT.91582295, DT.94270686, DT.99847758
NIA Mouse Gene IndexU023017
Consensus CDS ProjectCCDS38178.1, CCDS50632.1, CCDS50633.1, CCDS50634.1, CCDS50635.1, CCDS50636.1, CCDS50637.1, CCDS50638.1
International Mouse Knockout Project StatusMadd
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014395 VEGA Gene Model | MGI Sequence Detail 46478 C57BL/6J ±  kb
transcript OTTMUST00000034073 VEGA | MGI Sequence Detail 5990 Not Applicable 
polypeptide OTTMUSP00000015271 VEGA | MGI Sequence Detail 1632 Not Applicable 

For the selected sequences
All sequences(207) RefSeq(62) UniProt(15)
Polymorphisms SNPs within 2kb(251 from dbSNP Build 137)
InterPro IPR005112 dDENN domain
InterPro IPR001194 DENN domain
InterPro IPR005113 uDENN domain
Protein Ontology PR:000010042 MAP kinase-activating death domain protein
References (Earliest) J:126869 Tanaka M, et al., Role of Rab3 GDP/GTP exchange protein in synaptic vesicle trafficking at the mouse neuromuscular junction. Mol Biol Cell. 2001 May;12(5):1421-30
(Latest) J:193641 Nakano Y, et al., A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse. PLoS Genet. 2012;8(10):e1002966
All references(32)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory