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Madd
Gene Detail
Symbol

Name
ID
Madd
MAP-kinase activating death domain
MGI:2444672
Synonyms
9630059K23Rik, mKIAA0358, Rab3 GEP
Feature Type
protein coding gene
Genetic Map
Chromosome 2
50.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr2:91137360-91183837 bp, - strand
From VEGA annotation of GRCm38

  46478 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:14249  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: MAP kinase-activating death domain protein
Gene Tree: Madd

Human
homologs
Human Homolog MADD, MAP-kinase activating death domain
NCBI Gene ID 8567
neXtProt AC  NX_Q8WXG6
Human Synonyms  DENN, IG20, RAB3GEP
Human Chr (Location)  11p11.2; chr11:47269376-47330031 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Genomic Mutations involving Madd (2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele die shortly after birth due to respiratory failure, are hyporesponsive to tactile stimuli, and exhibit defects in neurotransmitter release with impaired synaptic vesicle trafficking and depletion of synaptic vesicles at the neuromuscular junction.
 
Interactions
Madd interacts with 174 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process activation of MAPK activity, apoptotic process, ...
Component cytoplasm, cytosol, ...
Function guanyl-nucleotide exchange factor activity, Rab guanyl-nucleotide exchange factor activity
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (105)    Tissues (18)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 105
cDNA source data(102)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(103) cDNA(103)
Microarray probesets(5)
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014395 VEGA Gene Model | MGI Sequence Detail 46478 C57BL/6J ±  kb
transcript OTTMUST00000034073 VEGA | MGI Sequence Detail 5990 Not Applicable 
polypeptide OTTMUSP00000015271 VEGA | MGI Sequence Detail 1632 Not Applicable 

For the selected sequences
All sequences(221) RefSeq(62) UniProt(29)
Polymorphisms
SNPs within 2kb(251 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005112 dDENN domain
InterPro IPR001194 DENN domain
InterPro IPR005113 uDENN domain
Protein Ontology PR:000010042 MAP kinase-activating death domain protein
References
(Earliest) J:126869 Tanaka M, et al., Role of Rab3 GDP/GTP exchange protein in synaptic vesicle trafficking at the mouse neuromuscular junction. Mol Biol Cell. 2001 May;12(5):1421-30
(Latest) J:193641 Nakano Y, et al., A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse. PLoS Genet. 2012;8(10):e1002966
All references(33)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory