Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes LTA4H
  • Mouse genes Lta4h
  • Rat genes Lta4h
  • Zfish genes lta4h
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Lta4h

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004177	aminopeptidase activity	LTA4H	IDA		Human	PMID:15078870
Molecular Function	GO:0004177	aminopeptidase activity	LTA4H	IDA		Human	PMID:18804029
Molecular Function	GO:0004177	aminopeptidase activity	LTA4H	IDA		Human	PMID:9774412
Molecular Function	GO:0004301	epoxide hydrolase activity	LTA4H	IMP		Human	PMID:11675384
Molecular Function	GO:0004301	epoxide hydrolase activity	LTA4H	IDA		Human	PMID:15078870
Molecular Function	GO:0004463	leukotriene-A4 hydrolase activity	LTA4H	IDA		Human	PMID:15078870
Molecular Function	GO:0004463	leukotriene-A4 hydrolase activity	LTA4H	IDA		Human	PMID:9774412
Molecular Function	GO:0004463	leukotriene-A4 hydrolase activity	Lta4h	IDA		Rat	PMID:3995081|RGD:2316605
Molecular Function	GO:0070006	metalloaminopeptidase activity	LTA4H	IMP		Human	PMID:11675384
Molecular Function	GO:0005515	protein binding	LTA4H	IPI	UniProtKB:Q9BSI4	Human	PMID:21044950
Molecular Function	GO:0005515	protein binding	Lta4h	IPI	PR:E9Q9D5	Mouse	PMID:23055941
Molecular Function	GO:0003723	RNA binding	LTA4H	HDA		Human	PMID:22658674
Molecular Function	GO:0008270	zinc ion binding	LTA4H	IMP		Human	PMID:11675384
Molecular Function	GO:0008270	zinc ion binding	LTA4H	IDA		Human	PMID:15078870
Molecular Function	GO:0008270	zinc ion binding	LTA4H	IDA		Human	PMID:18804029
Cellular Component	GO:0005737	cytoplasm	Lta4h	IDA		Rat	PMID:15805137|RGD:2316585
Cellular Component	GO:0005829	cytosol	LTA4H	IDA		Human	GO_REF:0000052
Cellular Component	GO:0070062	extracellular exosome	LTA4H	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	LTA4H	HDA		Human	PMID:23533145
Cellular Component	GO:0005654	nucleoplasm	LTA4H	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Lta4h	IDA		Rat	PMID:15805137|RGD:2316585
Biological Process	GO:0055113	epiboly involved in gastrulation with mouth forming second	lta4h	IMP	ZFIN:ZDB-MRPHLNO-100504-7	Zfish	PMID:25738285
Biological Process	GO:0006954	inflammatory response	lta4h	IMP	ZFIN:ZDB-GENO-100504-5	Zfish	PMID:20211140
Biological Process	GO:0006954	inflammatory response	lta4h	IMP	ZFIN:ZDB-GENO-100504-4	Zfish	PMID:20211140
Biological Process	GO:0019370	leukotriene biosynthetic process	LTA4H	IMP		Human	PMID:11675384
Biological Process	GO:0019370	leukotriene biosynthetic process	LTA4H	IDA		Human	PMID:15078870
Biological Process	GO:0019370	leukotriene biosynthetic process	LTA4H	IDA		Human	PMID:9774412
Biological Process	GO:0006691	leukotriene metabolic process	Lta4h	IDA		Rat	PMID:3995081|RGD:2316605
Biological Process	GO:0030593	neutrophil chemotaxis	lta4h	IMP	ZFIN:ZDB-MRPHLNO-100504-7	Zfish	PMID:25582859
Biological Process	GO:0043171	peptide catabolic process	LTA4H	IDA		Human	PMID:15078870
Biological Process	GO:0043171	peptide catabolic process	LTA4H	IDA		Human	PMID:18804029
Biological Process	GO:0043171	peptide catabolic process	LTA4H	IDA		Human	PMID:9774412
Biological Process	GO:0019538	protein metabolic process	LTA4H	IMP		Human	PMID:11675384
Biological Process	GO:0009617	response to bacterium	lta4h	IMP	ZFIN:ZDB-MRPHLNO-171122-3	Zfish	PMID:28658259
Biological Process	GO:0043434	response to peptide hormone	Lta4h	IEP		Rat	PMID:10601658|RGD:2316591
Biological Process	GO:0010043	response to zinc ion	Lta4h	IEP		Rat	PMID:17985342|RGD:2316582
Biological Process	GO:0060509	type I pneumocyte differentiation	Lta4h	IEP		Rat	PMID:15805137|RGD:2316585

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern