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Lta4h Gene Detail
Summary
  • Symbol
    Lta4h
  • Name
    leukotriene A4 hydrolase
  • Synonyms
    LTA4 hydrodase
  • Feature Type
    protein coding gene
  • IDs
    MGI:96836
    NCBI Gene: 16993
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr10:93453411-93484875 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      31465 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 48.42 cM, cytoband C3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    LTA4H, leukotriene A4 hydrolase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LTA4H, leukotriene A4 hydrolase
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 4048
    neXtProt AC: NX_P09960
    UniProt: P09960

  • Chr Location
    12q23.1; chr12:96000753-96043520 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene have grossly normal phenotypes. Inflammatory reactions are reduced as are some other immunological responses.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000015889 Ensembl Gene Model | MGI Sequence Detail 31465 C57BL/6J ±  kb
transcript ENSMUST00000016033 Ensembl | MGI Sequence Detail 2029 Not Applicable  
polypeptide ENSMUSP00000016033 Ensembl | MGI Sequence Detail 611 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    376 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 150
    cDNA 149
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-11898
References
more
  • Summaries
    All 52
    Developmental Gene Expression 3
    Gene Ontology 6
    Phenotypes 22
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/10/2017
MGI 6.10
The Jackson Laboratory