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Lta4h Gene Detail
Summary
  • Symbol
    Lta4h
  • Name
    leukotriene A4 hydrolase
  • Synonyms
    LTA4 hydrodase
  • Feature Type
    protein coding gene
  • IDs
    MGI:96836
    NCBI Gene: 16993
Location & Maps
more
  • Sequence Map
    Chr10:93453396-93484896 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      31501 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 48.42 cM, cytoband C3
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    LTA4H, leukotriene A4 hydrolase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LTA4H, leukotriene A4 hydrolase
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 4048
    neXtProt AC: NX_P09960

  • Chr Location
    12q22; chr12:96000753-96043520 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Gene trapped
    2
  • Targeted
    4
  • Transposon induced
    1
  • Genomic Mutations
    2 involving Lta4h
  • Incidental Mutations
Mice homozygous for disruptions in this gene have grossly normal phenotypes. Inflammatory reactions are reduced as are some other immunological responses.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000015889 Ensembl Gene Model | MGI Sequence Detail 31501 C57BL/6J ±  kb
transcript ENSMUST00000016033 Ensembl | MGI Sequence Detail 2066 Not Applicable  
polypeptide ENSMUSP00000016033 Ensembl | MGI Sequence Detail 611 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    376 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000009972 leukotriene A-4 hydrolase
  • EC
  • InterPro Domains
    IPR016024 Armadillo-type fold
    IPR012777 Leukotriene A4 hydrolase
    IPR001930 Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase
    IPR015211 Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal
    IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal
Molecular
Reagents
less
  • All nucleic 150
    cDNA 149
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-11898
References
more
  • Summaries
    All 44
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 21
  • Earliest
    J:11211 Medina JF, et al., Molecular cloning and expression of mouse leukotriene A4 hydrolase cDNA. Biochem Biophys Res Commun. 1991 May 15;176(3):1516-24
  • Latest
    J:227220 Akthar S, et al., Matrikines are key regulators in modulating the amplitude of lung inflammation in acute pulmonary infection. Nat Commun. 2015;6:8423

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory