Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes LGALS3
  • Mouse genes Lgals3
  • Rat genes Lgals3
  • Zfish genes lgals3a,lgals3b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Lgals3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0050785	advanced glycation end-product receptor activity	Lgals3	IDA		Rat	PMID:8529130|RGD:9685219
Molecular Function	GO:0030246	carbohydrate binding	LGALS3	EXP		Human	PMID:28973299
Molecular Function	GO:0042056	chemoattractant activity	LGALS3	IDA		Human	PMID:10925302
Molecular Function	GO:0048030	disaccharide binding	Lgals3	IDA		Rat	PMID:2249984|RGD:9685211
Molecular Function	GO:0034988	Fc-gamma receptor I complex binding	Lgals3	IDA		Rat	PMID:8347574|RGD:9685207
Molecular Function	GO:0019863	IgE binding	LGALS3	IDA		Human	PMID:2261464
Molecular Function	GO:0019863	IgE binding	Lgals3	IDA		Rat	PMID:2249984|RGD:9685211
Molecular Function	GO:0043236	laminin binding	LGALS3	IDA		Human	PMID:2402511
Molecular Function	GO:0140693	molecular condensate scaffold activity	LGALS3	IDA		Human	PMID:28893908
Molecular Function	GO:0140693	molecular condensate scaffold activity	LGALS3	IDA		Human	PMID:32144274
Molecular Function	GO:0048029	monosaccharide binding	Lgals3	IDA		Rat	PMID:2249984|RGD:9685211
Molecular Function	GO:0005515	protein binding	LGALS3	IPI	UniProtKB:P24539	Human	PMID:19016746
Molecular Function	GO:0005515	protein binding	LGALS3	IPI	UniProtKB:Q8WUM4	Human	PMID:19706535
Molecular Function	GO:0005515	protein binding	LGALS3	IPI	UniProtKB:Q9WU78-1	Human	PMID:19706535
Molecular Function	GO:0005515	protein binding	LGALS3	IPI	UniProtKB:P09237	Human	PMID:20812334
Molecular Function	GO:0005515	protein binding	LGALS3	IPI	UniProtKB:Q29983	Human	PMID:21712812
Molecular Function	GO:0005515	protein binding	LGALS3	IPI	UniProtKB:P12763	Human	PMID:2402511
Molecular Function	GO:0005515	protein binding	LGALS3	IPI	UniProtKB:P30203	Human	PMID:24945728
Molecular Function	GO:0005515	protein binding	LGALS3	IPI	UniProtKB:Q13740	Human	PMID:24945728
Molecular Function	GO:0005515	protein binding	LGALS3	IPI	UniProtKB:O14931	Human	PMID:25315772
Molecular Function	GO:0005515	protein binding	LGALS3	IPI	UniProtKB:O14931-2	Human	PMID:25315772
Molecular Function	GO:0005515	protein binding	LGALS3	IPI	UniProtKB:O75177	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	LGALS3	IPI	UniProtKB:Q08379	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	LGALS3	IPI	UniProtKB:Q13427	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	LGALS3	IPI	UniProtKB:Q9NZ81	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	LGALS3	IPI	UniProtKB:P36222	Human	PMID:29427412
Molecular Function	GO:0005515	protein binding	LGALS3	IPI	UniProtKB:Q14627	Human	PMID:29427412
Molecular Function	GO:0005515	protein binding	LGALS3	IPI	UniProtKB:Q9NZ81	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	LGALS3	IPI	UniProtKB:P17813	Human	PMID:31540324
Molecular Function	GO:0005515	protein binding	LGALS3	IPI	UniProtKB:O43186	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LGALS3	IPI	UniProtKB:Q0VD86	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LGALS3	IPI	UniProtKB:Q96L93-6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LGALS3	IPI	UniProtKB:P0DTC2	Human	PMID:32915505
Molecular Function	GO:0005515	protein binding	Lgals3	IPI	UniProtKB:Q61362	Mouse	MGI:MGI:6121636|PMID:29427412
Molecular Function	GO:0005515	protein binding	Lgals3	IPI	UniProtKB:Q9Z0P7	Mouse	MGI:MGI:5009176|PMID:14611647
Molecular Function	GO:0005515	protein binding	Lgals3	IPI	UniProtKB:O88786	Mouse	MGI:MGI:6121636|PMID:29427412
Molecular Function	GO:0005515	protein binding	Lgals3	IPI	PR:Q9JLB4	Mouse	PMID:11856751
Molecular Function	GO:0005515	protein binding	Lgals3	IPI	PR:Q9QXA1	Mouse	PMID:10745073
Molecular Function	GO:0019903	protein phosphatase binding	LGALS3	IPI	UniProtKB:O14522	Human	PMID:24846175
Molecular Function	GO:0003723	RNA binding	LGALS3	HDA		Human	PMID:22658674
Cellular Component	GO:0009986	cell surface	Lgals3	IDA		Mouse	MGI:MGI:5619731|PMID:23576987
Cellular Component	GO:0009986	cell surface	Lgals3	IDA		Rat	PMID:21401967|RGD:13792533
Cellular Component	GO:0009986	cell surface	Lgals3	IDA		Rat	PMID:9241534|RGD:9685208
Cellular Component	GO:0062023	collagen-containing extracellular matrix	LGALS3	HDA		Human	PMID:20551380
Cellular Component	GO:0062023	collagen-containing extracellular matrix	LGALS3	HDA		Human	PMID:28327460
Cellular Component	GO:0062023	collagen-containing extracellular matrix	LGALS3	HDA		Human	PMID:27559042
Cellular Component	GO:0062023	collagen-containing extracellular matrix	LGALS3	HDA		Human	PMID:25037231
Cellular Component	GO:0062023	collagen-containing extracellular matrix	LGALS3	HDA		Human	PMID:28675934
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Lgals3	HDA		Mouse	MGI:MGI:6201834|PMID:22159717
Cellular Component	GO:0001533	cornified envelope	Lgals3	IDA		Mouse	PMID:26644517
Cellular Component	GO:0005737	cytoplasm	LGALS3	IDA		Human	PMID:14961764
Cellular Component	GO:0005737	cytoplasm	LGALS3	IDA		Human	PMID:22761016
Cellular Component	GO:0005737	cytoplasm	LGALS3	IDA		Human	PMID:9447709
Cellular Component	GO:0005737	cytoplasm	Lgals3	IDA		Mouse	PMID:10745073
Cellular Component	GO:0005737	cytoplasm	Lgals3	IDA		Mouse	PMID:11856751
Cellular Component	GO:0005737	cytoplasm	Lgals3	IDA		Rat	PMID:16673152|RGD:9685215
Cellular Component	GO:0005829	cytosol	LGALS3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0009897	external side of plasma membrane	Lgals3	IDA		Mouse	PMID:23460747
Cellular Component	GO:0070062	extracellular exosome	LGALS3	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	LGALS3	HDA		Human	PMID:19199708
Cellular Component	GO:0070062	extracellular exosome	LGALS3	HDA		Human	PMID:23533145
Cellular Component	GO:0031012	extracellular matrix	Lgals3	IDA		Mouse	PMID:15800063
Cellular Component	GO:0005576	extracellular region	LGALS3	HDA		Human	PMID:27068509
Cellular Component	GO:0005615	extracellular space	LGALS3	HDA		Human	PMID:22664934
Cellular Component	GO:0005615	extracellular space	LGALS3	HDA		Human	PMID:23580065
Cellular Component	GO:0005615	extracellular space	Lgals3	HDA		Mouse	MGI:MGI:5640941|PMID:24006456
Cellular Component	GO:0005615	extracellular space	Lgals3	IDA		Rat	PMID:9241534|RGD:9685208
Cellular Component	GO:0097386	glial cell projection	Lgals3	IDA		Mouse	PMID:20826656
Cellular Component	GO:0001772	immunological synapse	LGALS3	IDA		Human	PMID:19706535
Cellular Component	GO:0001772	immunological synapse	Lgals3	IDA		Mouse	MGI:MGI:4355752|PMID:19706535
Cellular Component	GO:0016020	membrane	LGALS3	HDA		Human	PMID:19946888
Cellular Component	GO:0005743	mitochondrial inner membrane	LGALS3	IDA		Human	PMID:19016746
Cellular Component	GO:0005654	nucleoplasm	LGALS3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	LGALS3	IDA		Human	PMID:14961764
Cellular Component	GO:0005634	nucleus	LGALS3	IDA		Human	PMID:22761016
Cellular Component	GO:0005634	nucleus	LGALS3	IDA		Human	PMID:7682704
Cellular Component	GO:0005634	nucleus	Lgals3	IDA		Mouse	PMID:10745073
Cellular Component	GO:0005634	nucleus	Lgals3	IDA		Rat	PMID:16673152|RGD:9685215
Biological Process	GO:0048245	eosinophil chemotaxis	LGALS3	IDA		Human	PMID:10925302
Biological Process	GO:0030855	epithelial cell differentiation	LGALS3	IEP		Human	PMID:21492153
Biological Process	GO:0030198	extracellular matrix organization	Lgals3	IGI	MGI:MGI:97011	Mouse	PMID:15800063
Biological Process	GO:0048246	macrophage chemotaxis	LGALS3	IDA		Human	PMID:10925302
Biological Process	GO:0002548	monocyte chemotaxis	LGALS3	IDA		Human	PMID:10925302
Biological Process	GO:0071674	mononuclear cell migration	LGALS3	IDA		Human	PMID:10925302
Biological Process	GO:0043066	negative regulation of apoptotic process	Lgals3	IDA		Rat	PMID:16600178|RGD:9685204
Biological Process	GO:1903769	negative regulation of cell proliferation in bone marrow	Lgals3	IDA		Rat	PMID:9241534|RGD:9685208
Biological Process	GO:0045806	negative regulation of endocytosis	LGALS3	IDA		Human	PMID:19706535
Biological Process	GO:0045806	negative regulation of endocytosis	Lgals3	IMP		Mouse	MGI:MGI:4355752|PMID:19706535
Biological Process	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	LGALS3	IDA		Human	PMID:22761016
Biological Process	GO:2000521	negative regulation of immunological synapse formation	Lgals3	IMP		Mouse	MGI:MGI:4355752|PMID:19706535
Biological Process	GO:2001189	negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	Lgals3	IMP		Mouse	MGI:MGI:4355752|PMID:19706535
Biological Process	GO:0050860	negative regulation of T cell receptor signaling pathway	Lgals3	IMP		Mouse	MGI:MGI:4355752|PMID:19706535
Biological Process	GO:0030593	neutrophil chemotaxis	LGALS3	IDA		Human	PMID:10925302
Biological Process	GO:0050918	positive chemotaxis	LGALS3	IDA		Human	PMID:10925302
Biological Process	GO:0045766	positive regulation of angiogenesis	Lgals3	IMP		Rat	PMID:19573520|RGD:9685216
Biological Process	GO:0090280	positive regulation of calcium ion import	LGALS3	IDA		Human	PMID:10925302
Biological Process	GO:0008284	positive regulation of cell population proliferation	Lgals3	IMP		Rat	PMID:19573520|RGD:9685216
Biological Process	GO:0071677	positive regulation of mononuclear cell migration	LGALS3	IDA		Human	PMID:10925302
Biological Process	GO:1903078	positive regulation of protein localization to plasma membrane	LGALS3	IDA		Human	PMID:24846175
Biological Process	GO:0031334	positive regulation of protein-containing complex assembly	LGALS3	IDA		Human	PMID:24846175
Biological Process	GO:0014064	positive regulation of serotonin secretion	Lgals3	IDA		Rat	PMID:8347574|RGD:9685207
Biological Process	GO:1902041	regulation of extrinsic apoptotic signaling pathway via death domain receptors	LGALS3	IMP		Human	PMID:8692888
Biological Process	GO:0070232	regulation of T cell apoptotic process	LGALS3	IDA		Human	PMID:8692888
Biological Process	GO:0042129	regulation of T cell proliferation	LGALS3	IMP		Human	PMID:8692888
Biological Process	GO:1905235	response to quercetin	Lgals3	IEP		Rat	PMID:28032729|RGD:150530464
Biological Process	GO:0001501	skeletal system development	Lgals3	IGI	MGI:MGI:97011	Mouse	PMID:15800063

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern