Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes LAG3
  • Mouse genes Lag3
  • Rat genes Lag3
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Lag3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042289	MHC class II protein binding	LAG3	IDA		Human	PMID:9159144
Molecular Function	GO:0042289	MHC class II protein binding	Lag3	IDA		Mouse	MGI:MGI:2385414|PMID:12209638
Molecular Function	GO:0042289	MHC class II protein binding	Lag3	IDA		Mouse	PMID:12421911
Molecular Function	GO:0005515	protein binding	LAG3	IPI	UniProtKB:Q08830	Human	PMID:30580966
Molecular Function	GO:0005515	protein binding	Lag3	IPI	UniProtKB:Q71KU9	Mouse	MGI:MGI:6273588|PMID:30580966
Molecular Function	GO:0004888	transmembrane signaling receptor activity	Lag3	IDA		Mouse	MGI:MGI:2385414|PMID:12209638
Molecular Function	GO:0004888	transmembrane signaling receptor activity	Lag3	IDA		Mouse	MGI:MGI:6273588|PMID:30580966
Molecular Function	GO:0004888	transmembrane signaling receptor activity	Lag3	IDA		Mouse	PMID:12421911
Cellular Component	GO:0009897	external side of plasma membrane	Lag3	IDA		Mouse	PMID:12421911
Cellular Component	GO:0009897	external side of plasma membrane	Lag3	IDA		Mouse	PMID:8602528
Cellular Component	GO:0005576	extracellular region	Lag3	IDA		Mouse	MGI:MGI:6273588|PMID:30580966
Cellular Component	GO:0005576	extracellular region	Lag3	IDA		Mouse	MGI:MGI:6294190|PMID:17245433
Biological Process	GO:0007166	cell surface receptor signaling pathway	Lag3	IDA		Mouse	MGI:MGI:6273588|PMID:30580966
Biological Process	GO:0007166	cell surface receptor signaling pathway	Lag3	IDA		Mouse	MGI:MGI:2385414|PMID:12209638
Biological Process	GO:0007166	cell surface receptor signaling pathway	Lag3	IDA		Mouse	PMID:12421911
Biological Process	GO:0032623	interleukin-2 production	Lag3	IDA		Mouse	PMID:12421911
Biological Process	GO:0042267	natural killer cell mediated cytotoxicity	Lag3	IDA		Mouse	PMID:8602528
Biological Process	GO:0042267	natural killer cell mediated cytotoxicity	Lag3	IMP	MGI:MGI:2176269	Mouse	PMID:8602528
Biological Process	GO:0032703	negative regulation of interleukin-2 production	Lag3	IDA		Mouse	PMID:12421911
Biological Process	GO:0045590	negative regulation of regulatory T cell differentiation	Lag3	IMP		Mouse	MGI:MGI:3510279|PMID:15485628
Biological Process	GO:0050868	negative regulation of T cell activation	Lag3	IDA		Mouse	MGI:MGI:6273588|PMID:30580966
Biological Process	GO:0050868	negative regulation of T cell activation	Lag3	IDA		Mouse	MGI:MGI:2385414|PMID:12209638
Biological Process	GO:0050868	negative regulation of T cell activation	Lag3	IDA		Mouse	PMID:12421911
Biological Process	GO:0002270	plasmacytoid dendritic cell activation	Lag3	IMP		Mouse	MGI:MGI:3831964|PMID:19201841
Biological Process	GO:0045954	positive regulation of natural killer cell mediated cytotoxicity	Lag3	IMP	MGI:MGI:2176269	Mouse	PMID:8602528
Biological Process	GO:0045954	positive regulation of natural killer cell mediated cytotoxicity	Lag3	IDA		Mouse	PMID:8602528
Biological Process	GO:0050776	regulation of immune response	Lag3	IDA		Mouse	MGI:MGI:6273588|PMID:30580966
Biological Process	GO:0042110	T cell activation	Lag3	IDA		Mouse	PMID:12421911

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern