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Lag3 Gene Detail
Summary
  • Symbol
    Lag3
  • Name
    lymphocyte-activation gene 3
  • Synonyms
    CD223, LAG-3, Ly66
  • Feature Type
    protein coding gene
  • IDs
    MGI:106588
    NCBI Gene: 16768
  • Gene Overview
    MyGene.info: LAG3
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:124904361-124911705 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 59.17 cM
Strain
Comparison
more
  • SNPs within 2kb
    3 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106588
protein coding gene Chr6:124904359-124912434 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031276
protein coding gene Chr6:128218555-128226955 (-)
A/J MGP_AJ_G0031246
protein coding gene Chr6:123390563-123397690 (-)
AKR/J MGP_AKRJ_G0031174
protein coding gene Chr6:126756504-126765885 (-)
BALB/cJ MGP_BALBcJ_G0031254
protein coding gene Chr6:122990920-122998362 (-)
C3H/HeJ MGP_C3HHeJ_G0030977
protein coding gene Chr6:126806331-126814595 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031710
protein coding gene Chr6:131595795-131605984 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028860
protein coding gene Chr6:120601328-120609407 (-)
CAST/EiJ MGP_CASTEiJ_G0030358
protein coding gene Chr6:127017437-127028067 (-)
CBA/J MGP_CBAJ_G0030938
protein coding gene Chr6:136634458-136642035 (-)
DBA/2J MGP_DBA2J_G0031094
protein coding gene Chr6:122318205-122326840 (-)
FVB/NJ MGP_FVBNJ_G0031044
protein coding gene Chr6:121220870-121228067 (-)
LP/J MGP_LPJ_G0031174
protein coding gene Chr6:128386707-128396248 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031082
protein coding gene Chr6:140685874-140693529 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031745
protein coding gene Chr6:126648285-126656763 (-)
PWK/PhJ MGP_PWKPhJ_G0030073
protein coding gene Chr6:120550211-120558186 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029902
protein coding gene Chr6:124731713-124741566 (-)
WSB/EiJ MGP_WSBEiJ_G0030443
protein coding gene Chr6:127013404-127022140 (-)



Homology
more
  • Human Ortholog
    LAG3, lymphocyte activating 3
  • Vertebrate Orthologs
    8
  • Human Ortholog
    LAG3, lymphocyte activating 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD223
  • Links
    NCBI Gene ID: 3902
    neXtProt AC: NX_P18627
    UniProt: P18627

  • Chr Location
    12p13.31; chr12:6772483-6778455 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene have a generally normal phenotype but do display reduced natural killer cell activity and increased T cell response to infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030124 Ensembl Gene Model | MGI Sequence Detail 7345 C57BL/6J ±  kb
transcript ENSMUST00000032217 Ensembl | MGI Sequence Detail 2001 Not Applicable  
polypeptide ENSMUSP00000032217 Ensembl | MGI Sequence Detail 521 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    Genomic 2
    cDNA 12

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-35044
References
more
  • Summaries
    All 51
    Gene Ontology 4
    Phenotypes 26
  • Earliest
    J:32509 Miyazaki T, et al., Independent modes of natural killing distinguished in mice lacking Lag3. Science. 1996 Apr 19;272(5260):405-8
  • Latest
    J:260063 Zhang Q, et al., LAG3 limits regulatory T cell proliferation and function in autoimmune diabetes. Sci Immunol. 2017 Mar 31;2(9)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory