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Gene Ontology Browser
Term Detail
GO term:MHC class II protein binding
Synonym: major histocompatibility complex class II binding
Synonym: major histocompatibility complex class II ligand
GO id:GO:0042289
Definition:Interacting selectively and non-covalently with major histocompatibility complex class II molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation.
CommentsNote that this term does not include binding to the antigen peptide bound to the MHC protein. Consider also annotating to the molecular function term 'peptide antigen binding ; GO:0042605' or one of its children.
Number of paths to term: 1

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-amolecular_function
                is-abinding
                        is-aprotein binding
                                is-areceptor binding
                                        is-aMHC protein binding
                                                is-aMHC class I protein binding +
                                                is-aMHC class Ib protein binding +
                                                is-aMHC class II protein binding [GO:0042289] (4 genes, 6 annotations)
                                                        is-aMHC class II protein binding, via antigen binding groove
                                                        is-aMHC class II protein binding, via lateral surface


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory