Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes KLRC4-KLRK1,KLRK1
  • Mouse genes Klrk1
  • Rat genes Klrk1
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Klrk1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	Klrk1	IPI	PR:O54709	Mouse	PMID:11567106
Molecular Function	GO:0019900	kinase binding	Klrk1	IPI	UniProtKB:O43914	Mouse	MGI:MGI:3054301|PMID:15294961
Molecular Function	GO:0042288	MHC class I protein binding	Klrk1	IPI	MGI:MGI:3649078	Mouse	PMID:18209064
Molecular Function	GO:0042288	MHC class I protein binding	Klrk1	IPI	PR:B1B212	Mouse	PMID:18209064
Molecular Function	GO:0032394	MHC class Ib receptor activity	Klrk1	IMP		Mouse	PMID:12645935
Molecular Function	GO:0005515	protein binding	KLRK1	IPI	UniProtKB:Q29983	Human	PMID:10426993
Molecular Function	GO:0005515	protein binding	KLRK1	IPI	UniProtKB:Q9UBK5	Human	PMID:10426994
Molecular Function	GO:0005515	protein binding	KLRK1	IPI	UniProtKB:Q29983	Human	PMID:11323699
Molecular Function	GO:0005515	protein binding	KLRK1	IPI	UniProtKB:Q9BZM4	Human	PMID:11754823
Molecular Function	GO:0005515	protein binding	KLRK1	IPI	UniProtKB:Q6H3X3	Human	PMID:15240696
Molecular Function	GO:0005515	protein binding	KLRK1	IPI	UniProtKB:Q8TD07	Human	PMID:15240696
Molecular Function	GO:0005515	protein binding	KLRK1	IPI	UniProtKB:Q8TD07-1	Human	PMID:18544572
Molecular Function	GO:0005515	protein binding	KLRK1	IPI	UniProtKB:Q8TD07-2	Human	PMID:18544572
Molecular Function	GO:0005515	protein binding	KLRK1	IPI	UniProtKB:Q8TD07-5	Human	PMID:18544572
Molecular Function	GO:0005515	protein binding	KLRK1	IPI	UniProtKB:Q8TD07-6	Human	PMID:18544572
Molecular Function	GO:0005515	protein binding	KLRK1	IPI	UniProtKB:Q9BZM4	Human	PMID:18544572
Molecular Function	GO:0005515	protein binding	KLRK1	IPI	UniProtKB:Q6H3X3	Human	PMID:19424970
Molecular Function	GO:0005515	protein binding	KLRK1	IPI	UniProtKB:Q9BZM5	Human	PMID:19424970
Molecular Function	GO:0005515	protein binding	KLRK1	IPI	UniProtKB:Q8TD07	Human	PMID:19436053
Molecular Function	GO:0005515	protein binding	KLRK1	IPI	UniProtKB:Q5VY80	Human	PMID:19658097
Molecular Function	GO:0005515	protein binding	KLRK1	IPI	UniProtKB:Q6H3X3	Human	PMID:19658097
Molecular Function	GO:0005515	protein binding	KLRK1	IPI	UniProtKB:Q8TD07	Human	PMID:19658097
Molecular Function	GO:0005515	protein binding	KLRK1	IPI	UniProtKB:Q29983	Human	PMID:21712812
Molecular Function	GO:0005515	protein binding	KLRK1	IPI	UniProtKB:P13688	Human	PMID:23696226
Molecular Function	GO:0005515	protein binding	KLRK1	IPI	UniProtKB:Q5VY80	Human	PMID:28559451
Molecular Function	GO:0005515	protein binding	KLRK1	IPI	UniProtKB:Q8TD07	Human	PMID:28559451
Molecular Function	GO:0005515	protein binding	KLRK1	IPI	UniProtKB:Q9BZM4	Human	PMID:28559451
Molecular Function	GO:0005515	protein binding	KLRK1	IPI	UniProtKB:Q9BZM5	Human	PMID:28559451
Molecular Function	GO:0005515	protein binding	KLRK1	IPI	UniProtKB:Q9BZM6	Human	PMID:28559451
Molecular Function	GO:0005515	protein binding	KLRK1	IPI	UniProtKB:Q08493-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Klrk1	IPI	UniProtKB:Q6H3X3|UniProtKB:Q8TD07	Mouse	MGI:MGI:6094815|PMID:18544572
Molecular Function	GO:0005515	protein binding	Klrk1	IPI	UniProtKB:Q9UBK5|UniProtKB:Q9UBK5	Mouse	MGI:MGI:3054301|PMID:15294961
Molecular Function	GO:0005515	protein binding	Klrk1	IPI	PR:Q9CZQ6	Mouse	PMID:11567106
Molecular Function	GO:0005515	protein binding	Klrk1	IPI	PR:O08603	Mouse	PMID:12645935
Molecular Function	GO:0005515	protein binding	Klrk1	IPI	MGI:MGI:1306817	Mouse	PMID:12645935
Molecular Function	GO:0005515	protein binding	Klrk1	IPI	MGI:MGI:1925027	Mouse	PMID:12645935
Molecular Function	GO:0005515	protein binding	Klrk1	IPI	RGD:1583663	Rat	PMID:16323246|RGD:9685180
Molecular Function	GO:0038023	signaling receptor activity	KLRK1	IDA		Human	PMID:17562706
Cellular Component	GO:0009986	cell surface	KLRK1	IDA		Human	PMID:10426994
Cellular Component	GO:0009986	cell surface	KLRK1	IDA		Human	PMID:15294961
Cellular Component	GO:0009986	cell surface	Klrk1	IDA		Mouse	MGI:MGI:3054301|PMID:15294961
Cellular Component	GO:0009986	cell surface	Klrk1	IDA		Mouse	PMID:11567106
Cellular Component	GO:0009986	cell surface	Klrk1	IDA		Rat	PMID:15048723|RGD:9685182
Cellular Component	GO:0009897	external side of plasma membrane	Klrk1	IDA		Mouse	PMID:14764662
Cellular Component	GO:0009897	external side of plasma membrane	Klrk1	IDA		Mouse	PMID:23610400
Cellular Component	GO:0009897	external side of plasma membrane	Klrk1	IDA		Mouse	PMID:16973387
Cellular Component	GO:0009897	external side of plasma membrane	Klrk1	IDA		Mouse	PMID:12645935
Cellular Component	GO:0009897	external side of plasma membrane	Klrk1	IDA		Mouse	PMID:14707119
Cellular Component	GO:0005886	plasma membrane	KLRK1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	KLRK1	IDA		Human	PMID:17562706
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Klrk1	IDA		Mouse	PMID:14764662
Biological Process	GO:0050830	defense response to Gram-positive bacterium	Klrk1	IDA		Mouse	PMID:14764662
Biological Process	GO:0030101	natural killer cell activation	Klrk1	IPI	UniProtKB:Q3TM01	Mouse	PMID:18209064
Biological Process	GO:0030101	natural killer cell activation	Klrk1	IPI	PR:B1B212	Mouse	PMID:18209064
Biological Process	GO:0030101	natural killer cell activation	Klrk1	IMP		Mouse	PMID:12645935
Biological Process	GO:0030101	natural killer cell activation	Klrk1	IPI	UniProtKB:B1B213	Mouse	PMID:18209064
Biological Process	GO:0042267	natural killer cell mediated cytotoxicity	KLRK1	IDA		Human	PMID:17562706
Biological Process	GO:0034260	negative regulation of GTPase activity	KLRK1	IDA		Human	PMID:22585739
Biological Process	GO:2000502	negative regulation of natural killer cell chemotaxis	KLRK1	IDA		Human	PMID:22585739
Biological Process	GO:0006809	nitric oxide biosynthetic process	Klrk1	IDA		Mouse	PMID:12645935
Biological Process	GO:0043065	positive regulation of apoptotic process	Klrk1	IMP		Rat	PMID:15048723|RGD:9685182
Biological Process	GO:0030887	positive regulation of myeloid dendritic cell activation	Klrk1	IDA		Rat	PMID:17369187|RGD:9685185
Biological Process	GO:0045954	positive regulation of natural killer cell mediated cytotoxicity	KLRK1	IDA		Human	PMID:15294961
Biological Process	GO:0045954	positive regulation of natural killer cell mediated cytotoxicity	Klrk1	IDA		Mouse	MGI:MGI:3054301|PMID:15294961
Biological Process	GO:0045954	positive regulation of natural killer cell mediated cytotoxicity	Klrk1	IMP		Mouse	PMID:12645935
Biological Process	GO:0002860	positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	Klrk1	IMP		Rat	PMID:16323246|RGD:9685180
Biological Process	GO:0045429	positive regulation of nitric oxide biosynthetic process	Klrk1	IDA		Mouse	PMID:12645935
Biological Process	GO:0032729	positive regulation of type II interferon production	Klrk1	IDA		Mouse	PMID:12645935
Biological Process	GO:0002223	stimulatory C-type lectin receptor signaling pathway	Klrk1	IMP		Mouse	PMID:12645935
Biological Process	GO:0032609	type II interferon production	Klrk1	IDA		Mouse	PMID:12645935

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern