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Klrk1 Gene Detail
Summary
  • Symbol
    Klrk1
  • Name
    killer cell lectin-like receptor subfamily K, member 1
  • Synonyms
    D6H12S2489E, Nkg2d, NKG2-D
  • Feature Type
    protein coding gene
  • IDs
    MGI:1196250
    NCBI Gene: 27007
  • Gene Overview
    MyGene.info: KLRK1
Location & Maps
more
  • Sequence Map
    Chr6:129610323-129623864 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      13542 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 63.44 cM
  • Mapping Data
    9 experiments
Homology
more
  • Human Ortholog
    KLRK1, killer cell lectin like receptor K1
  • Vertebrate Orthologs
    6
  • Human Ortholog
    KLRK1, killer cell lectin like receptor K1
    Orthology source: HGNC
  • Synonyms
    CD314, D12S2489E, KLR, NKG2D, NKG2-D
  • Links
    NCBI Gene ID: 22914
    neXtProt AC: NX_P26718

  • Chr Location
    12p13.2; chr12:10372353-10390054 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 3 alleles in 4 genetic backgrounds
    3 phenotypes from multigenic genotypes
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice have defects in Natural Killer (NK) cell development, diminished NK-mediated cytolysis of tumor cells, and resistance to MCMV infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032505 VEGA Gene Model | MGI Sequence Detail 13542 C57BL/6J ±  kb
transcript OTTMUST00000080884 VEGA | MGI Sequence Detail 1270 Not Applicable  
polypeptide OTTMUSP00000043132 VEGA | MGI Sequence Detail 232 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    175 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
less
Molecular
Reagents
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  • All nucleic 20
    Genomic 4
    cDNA 15
    Primer pair 1

    Microarray probesets 4
References
more
  • Summaries
    All 95
    Developmental Gene Expression 1
    Gene Ontology 11
    Phenotypes 30
  • Earliest
    J:45141 Vance RE, et al., Cloning of a mouse homolog of CD94 extends the family of C-type lectins on murine natural killer cells. Eur J Immunol. 1997 Dec;27(12):3236-41
  • Latest
    J:233053 Belting L, et al., Critical role of the NKG2D receptor for NK cell-mediated control and immune escape of B-cell lymphoma. Eur J Immunol. 2015 Sep;45(9):2593-601

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory