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Klrk1 Gene Detail
Summary
  • Symbol
    Klrk1
  • Name
    killer cell lectin-like receptor subfamily K, member 1
  • Synonyms
    D6H12S2489E, Nkg2d, NKG2-D
  • Feature Type
    protein coding gene
  • IDs
    MGI:1196250
    NCBI Gene: 27007
  • Gene Overview
    MyGene.info: KLRK1
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:129610323-129623864 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 63.44 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    175 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1196250
protein coding gene Chr6:129610323-129623864 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031354
protein coding gene Chr6:133284647-133298378 (-)
A/J MGP_AJ_G0031325
protein coding gene Chr6:128186612-128200207 (-)
AKR/J MGP_AKRJ_G0031253
protein coding gene Chr6:131685201-131699749 (-)
BALB/cJ MGP_BALBcJ_G0031332
protein coding gene Chr6:127833528-127849396 (-)
C3H/HeJ MGP_C3HHeJ_G0031056
protein coding gene Chr6:131883196-131897305 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031791
protein coding gene Chr6:136782712-136799192 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028937
protein coding gene Chr6:126506926-126519777 (-)
CAST/EiJ MGP_CASTEiJ_G0030434
protein coding gene Chr6:132120679-132136997 (-)
CBA/J MGP_CBAJ_G0031016
protein coding gene Chr6:142174010-142189828 (-)
DBA/2J MGP_DBA2J_G0031173
protein coding gene Chr6:127138798-127152283 (-)
FVB/NJ MGP_FVBNJ_G0031123
protein coding gene Chr6:126023847-126042435 (-)
LP/J MGP_LPJ_G0031253
protein coding gene Chr6:133504499-133521531 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031161
protein coding gene Chr6:146028685-146055466 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031824
protein coding gene Chr6:131765275-131780022 (-)
PWK/PhJ MGP_PWKPhJ_G0030152
protein coding gene Chr6:125423857-125437491 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029981
protein coding gene Chr6:129780498-129792125 (-)
WSB/EiJ MGP_WSBEiJ_G0030522
protein coding gene Chr6:132184316-132200438 (-)



Homology
more
  • Human Ortholog
    KLRK1, killer cell lectin like receptor K1
  • Vertebrate Orthologs
    6
  • Human Ortholog
    KLRK1, killer cell lectin like receptor K1
    Orthology source: HGNC
  • Synonyms
    CD314, D12S2489E, KLR, NKG2D, NKG2-D
  • Links
    NCBI Gene ID: 22914
    neXtProt AC: NX_P26718
    UniProt: P26718

  • Chr Location
    12p13.2; chr12:10372353-10390054 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 3 alleles in 4 genetic backgrounds
    3 phenotypes from multigenic genotypes
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice have defects in Natural Killer (NK) cell development, diminished NK-mediated cytolysis of tumor cells, and resistance to MCMV infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 27007 NCBI Gene Model | MGI Sequence Detail 13542 C57BL/6J ±  kb
transcript NM_033078 RefSeq | MGI Sequence Detail 3272 C57BL/6  
polypeptide O54709 UniProt | EBI | MGI Sequence Detail 232 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
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  • All nucleic 21
    Genomic 4
    cDNA 16
    Primer pair 1

    Microarray probesets 4
References
more
  • Summaries
    All 125
    Developmental Gene Expression 1
    Gene Ontology 14
    Phenotypes 36
  • Earliest
    J:45141 Vance RE, et al., Cloning of a mouse homolog of CD94 extends the family of C-type lectins on murine natural killer cells. Eur J Immunol. 1997 Dec;27(12):3236-41
  • Latest
    J:262257 Haspeslagh E, et al., Role of NKp46(+) natural killer cells in house dust mite-driven asthma. EMBO Mol Med. 2018 Apr;10(4)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory