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Klrk1
Gene Detail
Symbol

Name
ID
Klrk1
killer cell lectin-like receptor subfamily K, member 1
MGI:1196250
Synonyms
D6H12S2489E, Nkg2d, NKG2-D
Feature Type
protein coding gene
Genetic Map
Chromosome 6
63.44 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr6:129610323-129623864 bp, - strand
From VEGA annotation of GRCm38

  13542 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7209  Vertebrate Homology Class
1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Klrk1

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice have defects in Natural Killer (NK) cell development, diminished NK-mediated cytolysis of tumor cells, and resistance to MCMV infection.
 
Interactions
Klrk1 interacts with 276 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process cell differentiation, cellular response to lipopolysaccharide, ...
Component cell surface, external side of plasma membrane, ...
Function carbohydrate binding, kinase binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(15)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(20) Genomic(4) cDNA(15) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000032505 (Evidence)
Ensembl Gene ModelENSMUSG00000030149 (Evidence)
Entrez Gene27007 (Evidence)
UniGene8217
DFCITC1588467, TC1654782, TC1687590
DoTSDT.101339300, DT.101346781, DT.110480895, DT.87072035, DT.87072157, DT.94231532
NIA Mouse Gene IndexU027920
PDB1HQ8, 4PP8
Consensus CDS ProjectCCDS39660.1, CCDS39661.1, CCDS71846.1
International Mouse Knockout Project StatusKlrk1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032505 VEGA Gene Model | MGI Sequence Detail 13542 C57BL/6J ±  kb
transcript OTTMUST00000080884 VEGA | MGI Sequence Detail 1270 Not Applicable 
polypeptide OTTMUSP00000043132 VEGA | MGI Sequence Detail 232 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(6) UniProt(7)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(177 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001304 C-type lectin
InterPro IPR016187 C-type lectin fold
InterPro IPR016186 C-type lectin-like
Protein Ontology PR:000001828 NKG2-D type II integral membrane protein
References
(Earliest) J:45141 Vance RE, et al., Cloning of a mouse homolog of CD94 extends the family of C-type lectins on murine natural killer cells. Eur J Immunol. 1997 Dec;27(12):3236-41
(Latest) J:205864 Ibusuki A, et al., NKG2D Triggers Cytotoxicity in Murine Epidermal gammadelta T Cells via PI3K-Dependent, Syk/ZAP70-Independent Signaling Pathway. J Invest Dermatol. 2014 Feb;134(2):396-404
All references(87)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory