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Klrk1
Gene Detail
Symbol

Name
ID
Klrk1
killer cell lectin-like receptor subfamily K, member 1
MGI:1196250
Synonyms
D6H12S2489E, Nkg2d, NKG2-D
Feature Type
protein coding gene
Genetic Map
Chromosome 6
63.44 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr6:129610323-129623864 bp, - strand
From VEGA annotation of GRCm38

  13542 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7209  Vertebrate Homology Class
1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: KLRK1
Gene Tree: Klrk1

Human
homologs
KLRK1, killer cell lectin-like receptor subfamily K, member 1
Orthology source: HGNC

IDs:
NCBI Gene ID: 22914
neXtProt AC: NX_P26718

Human Synonyms: CD314, D12S2489E, KLR, NKG2D, NKG2-D

Human Chr (Location): 12p13.2-p12.3; chr12:10372353-10390054 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mice have defects in Natural Killer (NK) cell development, diminished NK-mediated cytolysis of tumor cells, and resistance to MCMV infection.
 
Interactions
Klrk1 interacts with 275 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process adaptive immune response, cell differentiation, ...
Component cell surface, external side of plasma membrane, ...
Function carbohydrate binding, kinase binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(15)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(20) Genomic(4) cDNA(15) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000032505 (Evidence)
Ensembl Gene Model ENSMUSG00000030149 (Evidence)
Entrez Gene 27007 (Evidence)
UniGene 8217
DFCI TC1588467, TC1654782, TC1687590
DoTS DT.101339300, DT.101346781, DT.110480895, DT.87072035, DT.87072157, DT.94231532
NIA Mouse Gene Index U027920
PDB 1HQ8, 4PP8
Consensus CDS Project CCDS39660.1, CCDS39661.1, CCDS71846.1
International Mouse Phenotyping Consortium Status Klrk1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032505 VEGA Gene Model | MGI Sequence Detail 13542 C57BL/6J ±  kb
transcript OTTMUST00000080884 VEGA | MGI Sequence Detail 1270 Not Applicable 
polypeptide OTTMUSP00000043132 VEGA | MGI Sequence Detail 232 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(8) UniProt(4)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(177 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001304 C-type lectin
InterPro IPR016187 C-type lectin fold
InterPro IPR016186 C-type lectin-like
Protein Ontology PR:000001828 NKG2-D type II integral membrane protein
References
(Earliest) J:45141 Vance RE, et al., Cloning of a mouse homolog of CD94 extends the family of C-type lectins on murine natural killer cells. Eur J Immunol. 1997 Dec;27(12):3236-41
(Latest) J:221188 Deng W, et al., Antitumor immunity. A shed NKG2D ligand that promotes natural killer cell activation and tumor rejection. Science. 2015 Apr 3;348(6230):136-9
All references(93)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory