Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes KDM8
  • Mouse genes Kdm8
  • Rat genes Kdm8
  • Zfish genes kdm8
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Kdm8

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004177	aminopeptidase activity	KDM8	IDA		Human	PMID:28847961
Molecular Function	GO:0003682	chromatin binding	KDM8	IDA		Human	PMID:20457893
Molecular Function	GO:0004175	endopeptidase activity	KDM8	IDA		Human	PMID:28847961
Molecular Function	GO:0051864	histone H3K36 demethylase activity	KDM8	IDA		Human	PMID:20457893
Molecular Function	GO:0035064	methylated histone binding	KDM8	IDA		Human	PMID:28847961
Molecular Function	GO:0106157	peptidyl-arginine 3-dioxygenase activity	KDM8	IDA		Human	PMID:29563586
Molecular Function	GO:0005515	protein binding	KDM8	IPI	UniProtKB:A6NED2	Human	PMID:24981860
Molecular Function	GO:0005515	protein binding	Kdm8	IPI	UniProtKB:Q8C4V4	Mouse	MGI:MGI:6270295|PMID:30500822
Cellular Component	GO:0005829	cytosol	KDM8	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	KDM8	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	KDM8	IDA		Human	PMID:20457893
Biological Process	GO:0032922	circadian regulation of gene expression	Kdm8	IMP		Mouse	MGI:MGI:6270295|PMID:30500822
Biological Process	GO:0000086	G2/M transition of mitotic cell cycle	KDM8	IMP		Human	PMID:20457893
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	KDM8	IMP		Human	PMID:30500822
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	KDM8	IMP		Human	PMID:20457893
Biological Process	GO:0031648	protein destabilization	KDM8	IMP		Human	PMID:30500822
Biological Process	GO:0031648	protein destabilization	Kdm8	IMP		Mouse	MGI:MGI:6270295|PMID:30500822

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern