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Gene Ontology Browser
Term Detail
GO term:G2/M transition of mitotic cell cycle
Synonym: mitotic G2/M transition
GO id:GO:0000086
Definition:The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex.
Number of paths to term: 16

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell cycle
                                        part-ofcell cycle process
                                                is-acell cycle phase transition
                                                        is-acell cycle G2/M phase transition
                                                                is-aG2/M transition of mitotic cell cycle [GO:0000086] (70 genes, 75 annotations)
                                                                        negatively-regulatesnegative regulation of G2/M transition of mitotic cell cycle +
                                                                        positively-regulatespositive regulation of G2/M transition of mitotic cell cycle
                                                                        part-ofregulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle +
                                                                        regulatesregulation of G2/M transition of mitotic cell cycle +
                                                                        part-ofregulation of transcription involved in G2/M transition of mitotic cell cycle +
                                                                is-ameiotic G2/MI transition
                                                                negatively-regulatesnegative regulation of cell cycle G2/M phase transition +
                                                                positively-regulatespositive regulation of cell cycle G2/M phase transition +
                                                                regulatesregulation of cell cycle G2/M phase transition +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell cycle
                                        part-ofcell cycle process
                                                is-acell cycle phase transition
                                                        is-amitotic cell cycle phase transition
                                                                is-aG1/S transition of mitotic cell cycle +
                                                                is-aG2/M transition of mitotic cell cycle [GO:0000086] (70 genes, 75 annotations)
                                                                        negatively-regulatesnegative regulation of G2/M transition of mitotic cell cycle +
                                                                        positively-regulatespositive regulation of G2/M transition of mitotic cell cycle
                                                                        part-ofregulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle +
                                                                        regulatesregulation of G2/M transition of mitotic cell cycle +
                                                                        part-ofregulation of transcription involved in G2/M transition of mitotic cell cycle +
                                                                is-ametaphase/anaphase transition of mitotic cell cycle +
                                                                negatively-regulatesnegative regulation of mitotic cell cycle phase transition +
                                                                positively-regulatespositive regulation of mitotic cell cycle phase transition +
                                                                regulatesregulation of mitotic cell cycle phase transition +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell cycle
                                        part-ofcell cycle process
                                                is-amitotic cell cycle process
                                                        is-amitotic cell cycle phase transition
                                                                is-aG1/S transition of mitotic cell cycle +
                                                                is-aG2/M transition of mitotic cell cycle [GO:0000086] (70 genes, 75 annotations)
                                                                        negatively-regulatesnegative regulation of G2/M transition of mitotic cell cycle +
                                                                        positively-regulatespositive regulation of G2/M transition of mitotic cell cycle
                                                                        part-ofregulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle +
                                                                        regulatesregulation of G2/M transition of mitotic cell cycle +
                                                                        part-ofregulation of transcription involved in G2/M transition of mitotic cell cycle +
                                                                is-ametaphase/anaphase transition of mitotic cell cycle +
                                                                negatively-regulatesnegative regulation of mitotic cell cycle phase transition +
                                                                positively-regulatespositive regulation of mitotic cell cycle phase transition +
                                                                regulatesregulation of mitotic cell cycle phase transition +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell cycle
                                        is-amitotic cell cycle
                                                part-ofmitotic cell cycle phase transition
                                                        is-aG1/S transition of mitotic cell cycle +
                                                        is-aG2/M transition of mitotic cell cycle [GO:0000086] (70 genes, 75 annotations)
                                                                negatively-regulatesnegative regulation of G2/M transition of mitotic cell cycle +
                                                                positively-regulatespositive regulation of G2/M transition of mitotic cell cycle
                                                                part-ofregulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle +
                                                                regulatesregulation of G2/M transition of mitotic cell cycle +
                                                                part-ofregulation of transcription involved in G2/M transition of mitotic cell cycle +
                                                        is-ametaphase/anaphase transition of mitotic cell cycle +
                                                        negatively-regulatesnegative regulation of mitotic cell cycle phase transition +
                                                        positively-regulatespositive regulation of mitotic cell cycle phase transition +
                                                        regulatesregulation of mitotic cell cycle phase transition +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell cycle
                                        is-amitotic cell cycle
                                                part-ofmitotic cell cycle process
                                                        is-amitotic cell cycle phase transition
                                                                is-aG1/S transition of mitotic cell cycle +
                                                                is-aG2/M transition of mitotic cell cycle [GO:0000086] (70 genes, 75 annotations)
                                                                        negatively-regulatesnegative regulation of G2/M transition of mitotic cell cycle +
                                                                        positively-regulatespositive regulation of G2/M transition of mitotic cell cycle
                                                                        part-ofregulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle +
                                                                        regulatesregulation of G2/M transition of mitotic cell cycle +
                                                                        part-ofregulation of transcription involved in G2/M transition of mitotic cell cycle +
                                                                is-ametaphase/anaphase transition of mitotic cell cycle +
                                                                negatively-regulatesnegative regulation of mitotic cell cycle phase transition +
                                                                positively-regulatespositive regulation of mitotic cell cycle phase transition +
                                                                regulatesregulation of mitotic cell cycle phase transition +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell cycle process
                                        is-acell cycle phase transition
                                                is-acell cycle G2/M phase transition
                                                        is-aG2/M transition of mitotic cell cycle [GO:0000086] (70 genes, 75 annotations)
                                                                negatively-regulatesnegative regulation of G2/M transition of mitotic cell cycle +
                                                                positively-regulatespositive regulation of G2/M transition of mitotic cell cycle
                                                                part-ofregulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle +
                                                                regulatesregulation of G2/M transition of mitotic cell cycle +
                                                                part-ofregulation of transcription involved in G2/M transition of mitotic cell cycle +
                                                        is-ameiotic G2/MI transition
                                                        negatively-regulatesnegative regulation of cell cycle G2/M phase transition +
                                                        positively-regulatespositive regulation of cell cycle G2/M phase transition +
                                                        regulatesregulation of cell cycle G2/M phase transition +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell cycle process
                                        is-acell cycle phase transition
                                                is-amitotic cell cycle phase transition
                                                        is-aG1/S transition of mitotic cell cycle +
                                                        is-aG2/M transition of mitotic cell cycle [GO:0000086] (70 genes, 75 annotations)
                                                                negatively-regulatesnegative regulation of G2/M transition of mitotic cell cycle +
                                                                positively-regulatespositive regulation of G2/M transition of mitotic cell cycle
                                                                part-ofregulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle +
                                                                regulatesregulation of G2/M transition of mitotic cell cycle +
                                                                part-ofregulation of transcription involved in G2/M transition of mitotic cell cycle +
                                                        is-ametaphase/anaphase transition of mitotic cell cycle +
                                                        negatively-regulatesnegative regulation of mitotic cell cycle phase transition +
                                                        positively-regulatespositive regulation of mitotic cell cycle phase transition +
                                                        regulatesregulation of mitotic cell cycle phase transition +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell cycle process
                                        is-amitotic cell cycle process
                                                is-amitotic cell cycle phase transition
                                                        is-aG1/S transition of mitotic cell cycle +
                                                        is-aG2/M transition of mitotic cell cycle [GO:0000086] (70 genes, 75 annotations)
                                                                negatively-regulatesnegative regulation of G2/M transition of mitotic cell cycle +
                                                                positively-regulatespositive regulation of G2/M transition of mitotic cell cycle
                                                                part-ofregulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle +
                                                                regulatesregulation of G2/M transition of mitotic cell cycle +
                                                                part-ofregulation of transcription involved in G2/M transition of mitotic cell cycle +
                                                        is-ametaphase/anaphase transition of mitotic cell cycle +
                                                        negatively-regulatesnegative regulation of mitotic cell cycle phase transition +
                                                        positively-regulatespositive regulation of mitotic cell cycle phase transition +
                                                        regulatesregulation of mitotic cell cycle phase transition +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell cycle
                                        part-ofcell cycle process
                                                is-acell cycle phase transition
                                                        is-acell cycle G2/M phase transition
                                                                is-aG2/M transition of mitotic cell cycle [GO:0000086] (70 genes, 75 annotations)
                                                                        negatively-regulatesnegative regulation of G2/M transition of mitotic cell cycle +
                                                                        positively-regulatespositive regulation of G2/M transition of mitotic cell cycle
                                                                        part-ofregulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle +
                                                                        regulatesregulation of G2/M transition of mitotic cell cycle +
                                                                        part-ofregulation of transcription involved in G2/M transition of mitotic cell cycle +
                                                                is-ameiotic G2/MI transition
                                                                negatively-regulatesnegative regulation of cell cycle G2/M phase transition +
                                                                positively-regulatespositive regulation of cell cycle G2/M phase transition +
                                                                regulatesregulation of cell cycle G2/M phase transition +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell cycle
                                        part-ofcell cycle process
                                                is-acell cycle phase transition
                                                        is-amitotic cell cycle phase transition
                                                                is-aG1/S transition of mitotic cell cycle +
                                                                is-aG2/M transition of mitotic cell cycle [GO:0000086] (70 genes, 75 annotations)
                                                                        negatively-regulatesnegative regulation of G2/M transition of mitotic cell cycle +
                                                                        positively-regulatespositive regulation of G2/M transition of mitotic cell cycle
                                                                        part-ofregulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle +
                                                                        regulatesregulation of G2/M transition of mitotic cell cycle +
                                                                        part-ofregulation of transcription involved in G2/M transition of mitotic cell cycle +
                                                                is-ametaphase/anaphase transition of mitotic cell cycle +
                                                                negatively-regulatesnegative regulation of mitotic cell cycle phase transition +
                                                                positively-regulatespositive regulation of mitotic cell cycle phase transition +
                                                                regulatesregulation of mitotic cell cycle phase transition +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell cycle
                                        part-ofcell cycle process
                                                is-amitotic cell cycle process
                                                        is-amitotic cell cycle phase transition
                                                                is-aG1/S transition of mitotic cell cycle +
                                                                is-aG2/M transition of mitotic cell cycle [GO:0000086] (70 genes, 75 annotations)
                                                                        negatively-regulatesnegative regulation of G2/M transition of mitotic cell cycle +
                                                                        positively-regulatespositive regulation of G2/M transition of mitotic cell cycle
                                                                        part-ofregulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle +
                                                                        regulatesregulation of G2/M transition of mitotic cell cycle +
                                                                        part-ofregulation of transcription involved in G2/M transition of mitotic cell cycle +
                                                                is-ametaphase/anaphase transition of mitotic cell cycle +
                                                                negatively-regulatesnegative regulation of mitotic cell cycle phase transition +
                                                                positively-regulatespositive regulation of mitotic cell cycle phase transition +
                                                                regulatesregulation of mitotic cell cycle phase transition +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell cycle
                                        is-amitotic cell cycle
                                                part-ofmitotic cell cycle phase transition
                                                        is-aG1/S transition of mitotic cell cycle +
                                                        is-aG2/M transition of mitotic cell cycle [GO:0000086] (70 genes, 75 annotations)
                                                                negatively-regulatesnegative regulation of G2/M transition of mitotic cell cycle +
                                                                positively-regulatespositive regulation of G2/M transition of mitotic cell cycle
                                                                part-ofregulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle +
                                                                regulatesregulation of G2/M transition of mitotic cell cycle +
                                                                part-ofregulation of transcription involved in G2/M transition of mitotic cell cycle +
                                                        is-ametaphase/anaphase transition of mitotic cell cycle +
                                                        negatively-regulatesnegative regulation of mitotic cell cycle phase transition +
                                                        positively-regulatespositive regulation of mitotic cell cycle phase transition +
                                                        regulatesregulation of mitotic cell cycle phase transition +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell cycle
                                        is-amitotic cell cycle
                                                part-ofmitotic cell cycle process
                                                        is-amitotic cell cycle phase transition
                                                                is-aG1/S transition of mitotic cell cycle +
                                                                is-aG2/M transition of mitotic cell cycle [GO:0000086] (70 genes, 75 annotations)
                                                                        negatively-regulatesnegative regulation of G2/M transition of mitotic cell cycle +
                                                                        positively-regulatespositive regulation of G2/M transition of mitotic cell cycle
                                                                        part-ofregulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle +
                                                                        regulatesregulation of G2/M transition of mitotic cell cycle +
                                                                        part-ofregulation of transcription involved in G2/M transition of mitotic cell cycle +
                                                                is-ametaphase/anaphase transition of mitotic cell cycle +
                                                                negatively-regulatesnegative regulation of mitotic cell cycle phase transition +
                                                                positively-regulatespositive regulation of mitotic cell cycle phase transition +
                                                                regulatesregulation of mitotic cell cycle phase transition +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell cycle process
                                        is-acell cycle phase transition
                                                is-acell cycle G2/M phase transition
                                                        is-aG2/M transition of mitotic cell cycle [GO:0000086] (70 genes, 75 annotations)
                                                                negatively-regulatesnegative regulation of G2/M transition of mitotic cell cycle +
                                                                positively-regulatespositive regulation of G2/M transition of mitotic cell cycle
                                                                part-ofregulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle +
                                                                regulatesregulation of G2/M transition of mitotic cell cycle +
                                                                part-ofregulation of transcription involved in G2/M transition of mitotic cell cycle +
                                                        is-ameiotic G2/MI transition
                                                        negatively-regulatesnegative regulation of cell cycle G2/M phase transition +
                                                        positively-regulatespositive regulation of cell cycle G2/M phase transition +
                                                        regulatesregulation of cell cycle G2/M phase transition +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell cycle process
                                        is-acell cycle phase transition
                                                is-amitotic cell cycle phase transition
                                                        is-aG1/S transition of mitotic cell cycle +
                                                        is-aG2/M transition of mitotic cell cycle [GO:0000086] (70 genes, 75 annotations)
                                                                negatively-regulatesnegative regulation of G2/M transition of mitotic cell cycle +
                                                                positively-regulatespositive regulation of G2/M transition of mitotic cell cycle
                                                                part-ofregulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle +
                                                                regulatesregulation of G2/M transition of mitotic cell cycle +
                                                                part-ofregulation of transcription involved in G2/M transition of mitotic cell cycle +
                                                        is-ametaphase/anaphase transition of mitotic cell cycle +
                                                        negatively-regulatesnegative regulation of mitotic cell cycle phase transition +
                                                        positively-regulatespositive regulation of mitotic cell cycle phase transition +
                                                        regulatesregulation of mitotic cell cycle phase transition +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell cycle process
                                        is-amitotic cell cycle process
                                                is-amitotic cell cycle phase transition
                                                        is-aG1/S transition of mitotic cell cycle +
                                                        is-aG2/M transition of mitotic cell cycle [GO:0000086] (70 genes, 75 annotations)
                                                                negatively-regulatesnegative regulation of G2/M transition of mitotic cell cycle +
                                                                positively-regulatespositive regulation of G2/M transition of mitotic cell cycle
                                                                part-ofregulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle +
                                                                regulatesregulation of G2/M transition of mitotic cell cycle +
                                                                part-ofregulation of transcription involved in G2/M transition of mitotic cell cycle +
                                                        is-ametaphase/anaphase transition of mitotic cell cycle +
                                                        negatively-regulatesnegative regulation of mitotic cell cycle phase transition +
                                                        positively-regulatespositive regulation of mitotic cell cycle phase transition +
                                                        regulatesregulation of mitotic cell cycle phase transition +


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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory