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Kdm8 Gene Detail
Summary
  • Symbol
    Kdm8
  • Name
    lysine (K)-specific demethylase 8
  • Synonyms
    3110005O21Rik, Jmjd5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924285
    NCBI Gene: 77035
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:125043848-125061441 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 68.85 cM, cytoband F3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    705 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924285
 protein coding gene Chr7:125043788-125062823 (+)
129S1/SvImJ ENSMUSG00200021049
 protein coding gene Chr7:111554115-111571682 (+)
A/J ENSMUSG00195037222
 protein coding gene Chr7:116080076-116097648 (+)
AKR/J ENSMUSG00220021044
 protein coding gene Chr7:109494998-109512707 (+)
BALB/cJ ENSMUSG00180013347
 protein coding gene Chr7:112735616-112753347 (+)
C3H/HeJ ENSMUSG00175017110
 protein coding gene Chr7:113471585-113489184 (+)
C57BL/6NJ ENSMUSG00215008793
 protein coding gene Chr7:112751358-112768951 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030432
 protein coding gene Chr7:127465272-127482945 (+)
CAST/EiJ ENSTCUG00005044034
 protein coding gene Chr7:115973081-115990617 (+)
CBA/J ENSMUSG00210022508
 protein coding gene Chr7:113232564-113250159 (+)
DBA/2J ENSMUSG00185049852
 protein coding gene Chr7:117545422-117563019 (+)
FVB/NJ ENSMUSG00205014524
 protein coding gene Chr7:113189950-113207517 (+)
JF1/MsJ ENSUMUG00000019450
 protein coding gene Chr7:122582769-122600515 (+)
LP/J ENSMUSG00230052059
 protein coding gene Chr7:123654127-123671692 (+)
NOD/ShiLtJ ENSMUSG00190014486
 protein coding gene Chr7:113398730-113416312 (+)
NZO/HlLtJ ENSMUSG00225011683
 protein coding gene Chr7:121892765-121910349 (+)
PWK/PhJ ENSLUMG00010011553
 protein coding gene Chr7:111739088-111756681 (+)
SPRET/EiJ ENSMSPG00010010558
 protein coding gene Chr7:113001733-113019195 (+)
WSB/EiJ ENSIUOG00005024873
 protein coding gene Chr7:114097029-114115093 (+)



Homology
more
  • Human Ortholog
    KDM8, lysine demethylase 8 (putative)
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KDM8, lysine demethylase 8 (putative)
  • Synonyms
    JMJD5
  • Links
    NCBI Gene ID: 79831
    UniProt: Q8N371

  • Chr Location
    16p12.1; chr16:27203486-27225987 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 6 alleles in 5 genetic backgrounds
    4 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene leads to complete embryonic lethality during organogenesis associated with severe growth retardation and abnormal embryo turning. Observed phenotypes include open neural tubes and absent vitelline blood vessels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    56
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    692
  • Tissues
    63
  • cDNA Data
    22
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030752 Ensembl Gene Model | MGI Sequence Detail 17594 C57BL/6J ±  kb
    transcript ENSMUST00000033010 Ensembl | MGI Sequence Detail 2389 Not Applicable  
    polypeptide ENSMUSP00000033010 Ensembl | MGI Sequence Detail 414 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      cDNA 22
      Primer pair 3

      Microarray probesets 3
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 10
      Gene Ontology 11
      Phenotypes 17
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:350444 Martinez-Mayer J, et al., Knockout mice with pituitary malformations help identify human cases of hypopituitarism. Genome Med. 2024 May 31;16(1):75
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory