Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Irs2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes IRS2
- Mouse genes Irs2
- Rat genes Irs2
- Zfish genes irs2a,irs2b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Irs2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0071889	14-3-3 protein binding	Irs2	IDA		Rat	PMID:22912850\|RGD:7257698
Molecular Function	GO:0005158	insulin receptor binding	Irs2	IMP		Rat	PMID:12850498\|RGD:1580595
Molecular Function	GO:0140677	molecular function activator activity	Irs2	IDA		Mouse	PMID:8649419
Molecular Function	GO:0140677	molecular function activator activity	Irs2	IDA		Mouse	PMID:7534300
Molecular Function	GO:0043548	phosphatidylinositol 3-kinase binding	Irs2	IDA		Mouse	PMID:11375348
Molecular Function	GO:0043548	phosphatidylinositol 3-kinase binding	Irs2	IMP		Rat	PMID:12850498\|RGD:1580595
Molecular Function	GO:0043548	phosphatidylinositol 3-kinase binding	Irs2	IPI	RGD:3329	Rat	PMID:12891559\|RGD:1299201
Molecular Function	GO:0005515	protein binding	IRS2	IPI	UniProtKB:P63104	Human	PMID:15161933
Molecular Function	GO:0005515	protein binding	IRS2	IPI	UniProtKB:Q96EB6	Human	PMID:17901049
Molecular Function	GO:0005515	protein binding	IRS2	IPI	UniProtKB:P27986	Human	PMID:21241768
Molecular Function	GO:0005515	protein binding	IRS2	IPI	UniProtKB:Q96EB6	Human	PMID:21241768
Molecular Function	GO:0005515	protein binding	IRS2	IPI	UniProtKB:P27986	Human	PMID:23617393
Molecular Function	GO:0005515	protein binding	IRS2	IPI	UniProtKB:P27986	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	IRS2	IPI	UniProtKB:P63104	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	IRS2	IPI	UniProtKB:P63104	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	Irs2	IPI	UniProtKB:P06213-1	Mouse	MGI:MGI:5925484\|PMID:18278056
Molecular Function	GO:0005515	protein binding	Irs2	IPI	UniProtKB:Q923E4	Mouse	MGI:MGI:3767135\|PMID:17901049
Molecular Function	GO:0005515	protein binding	Irs2	IPI	PR:P26450	Mouse	PMID:26657864
Molecular Function	GO:0005515	protein binding	Irs2	IPI	PR:Q8BHZ4	Mouse	PMID:9813005
Molecular Function	GO:0005515	protein binding	Irs2	IPI	PR:Q8CGK3	Mouse	PMID:9813005
Molecular Function	GO:0005515	protein binding	Irs2	IPI	PR:P09405	Mouse	PMID:9813005
Molecular Function	GO:0005515	protein binding	Irs2	IPI	RGD:1303075	Rat	PMID:21742014\|RGD:5686378
Molecular Function	GO:0019904	protein domain specific binding	Irs2	IPI	RGD:619758	Rat	PMID:12891559\|RGD:1299201
Molecular Function	GO:0019901	protein kinase binding	Irs2	IDA		Mouse	PMID:14733908
Molecular Function	GO:0019903	protein phosphatase binding	Irs2	IPI	RGD:3447	Rat	PMID:12891559\|RGD:1299201
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	Irs2	IDA		Mouse	PMID:8649419
Molecular Function	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity	Irs2	IDA		Mouse	PMID:7534300
Cellular Component	GO:0005829	cytosol	Irs2	IDA		Mouse	PMID:17636024
Cellular Component	GO:0005886	plasma membrane	Irs2	IDA		Mouse	PMID:11375348
Cellular Component	GO:0032991	protein-containing complex	Irs2	IDA		Mouse	PMID:26657864
Biological Process	GO:0007420	brain development	Irs2	IMP	MGI:MGI:2158686	Mouse	PMID:12904469
Biological Process	GO:0016477	cell migration	Irs2	IGI	MGI:MGI:99454	Mouse	PMID:17662267
Biological Process	GO:0008283	cell population proliferation	Irs2	IGI	MGI:MGI:1932404	Mouse	PMID:17636024
Biological Process	GO:0008283	cell population proliferation	Irs2	IMP	MGI:MGI:2158686	Mouse	PMID:12904469
Biological Process	GO:0008283	cell population proliferation	Irs2	IGI	MGI:MGI:96432	Mouse	PMID:17636024
Biological Process	GO:0071333	cellular response to glucose stimulus	Irs2	IEP		Rat	PMID:16574657\|RGD:7257701
Biological Process	GO:0032869	cellular response to insulin stimulus	IRS2	IMP		Human	PMID:16814735
Biological Process	GO:0032869	cellular response to insulin stimulus	Irs2	IDA		Mouse	PMID:11375348
Biological Process	GO:0032869	cellular response to insulin stimulus	Irs2	IDA		Rat	PMID:22912850\|RGD:7257698
Biological Process	GO:1901653	cellular response to peptide	Irs2	IEP		Rat	PMID:18406357\|RGD:2316543
Biological Process	GO:0010631	epithelial cell migration	Irs2	IGI	MGI:MGI:99454	Mouse	PMID:17662267
Biological Process	GO:0008286	insulin receptor signaling pathway	Irs2	IDA		Mouse	PMID:8649419
Biological Process	GO:0008286	insulin receptor signaling pathway	Irs2	IDA		Mouse	PMID:7534300
Biological Process	GO:0008286	insulin receptor signaling pathway	Irs2	IDA		Mouse	PMID:9813005
Biological Process	GO:0008286	insulin receptor signaling pathway	Irs2	IMP	MGI:MGI:2158686	Mouse	PMID:12488434
Biological Process	GO:0008286	insulin receptor signaling pathway	Irs2	IMP		Rat	PMID:12891559\|RGD:1299201
Biological Process	GO:0030879	mammary gland development	Irs2	IGI	MGI:MGI:99454	Mouse	PMID:17662267
Biological Process	GO:0002903	negative regulation of B cell apoptotic process	Irs2	IMP		Mouse	MGI:MGI:4456946\|PMID:15572028
Biological Process	GO:0033673	negative regulation of kinase activity	Irs2	IMP		Mouse	MGI:MGI:3851274\|PMID:19523444
Biological Process	GO:0010748	negative regulation of long-chain fatty acid import across plasma membrane	IRS2	IMP		Human	PMID:16814735
Biological Process	GO:0030890	positive regulation of B cell proliferation	Irs2	IDA		Mouse	MGI:MGI:4456946\|PMID:15572028
Biological Process	GO:0008284	positive regulation of cell population proliferation	Irs2	IMP	MGI:MGI:2158686	Mouse	PMID:12904469
Biological Process	GO:0010634	positive regulation of epithelial cell migration	Irs2	IGI	MGI:MGI:99454	Mouse	PMID:17662267
Biological Process	GO:0032000	positive regulation of fatty acid beta-oxidation	IRS2	IMP		Human	PMID:16814735
Biological Process	GO:0046326	positive regulation of glucose import	IRS2	IMP		Human	PMID:16814735
Biological Process	GO:0010907	positive regulation of glucose metabolic process	IRS2	IMP		Human	PMID:16814735
Biological Process	GO:0045725	positive regulation of glycogen biosynthetic process	IRS2	IMP		Human	PMID:16814735
Biological Process	GO:0032024	positive regulation of insulin secretion	Irs2	IMP		Mouse	MGI:MGI:4456946\|PMID:15572028
Biological Process	GO:0002053	positive regulation of mesenchymal cell proliferation	Irs2	IGI	MGI:MGI:99454	Mouse	PMID:17662267
Biological Process	GO:1904692	positive regulation of type B pancreatic cell proliferation	Irs2	IGI	MGI:MGI:1932404	Mouse	PMID:17636024
Biological Process	GO:1904692	positive regulation of type B pancreatic cell proliferation	Irs2	IGI	MGI:MGI:96432	Mouse	PMID:17636024
Biological Process	GO:0009749	response to glucose	Irs2	IDA		Mouse	MGI:MGI:4456946\|PMID:15572028
Biological Process	GO:0001666	response to hypoxia	irs2a	IMP	ZFIN:ZDB-MRPHLNO-150826-5	Zfish	PMID:25840431
Biological Process	GO:0001666	response to hypoxia	irs2a	IEP		Zfish	PMID:26697342
Biological Process	GO:0044342	type B pancreatic cell proliferation	Irs2	IGI	MGI:MGI:96432	Mouse	PMID:17636024
Biological Process	GO:0044342	type B pancreatic cell proliferation	Irs2	IGI	MGI:MGI:1932404	Mouse	PMID:17636024

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.