Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes INPP5E
  • Mouse genes Inpp5e
  • Rat genes Inpp5e
  • Zfish genes inpp5e
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Inpp5e

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004445	inositol-polyphosphate 5-phosphatase activity	Inpp5e	IDA		Rat	PMID:10405344|RGD:1299274
Molecular Function	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	Inpp5e	IDA		Rat	PMID:21436142|RGD:12911213
Molecular Function	GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	Inpp5e	IDA		Mouse	PMID:10806194
Molecular Function	GO:0106019	phosphatidylinositol-4,5-bisphosphate phosphatase activity	Inpp5e	IDA		Rat	PMID:21436142|RGD:12911213
Cellular Component	GO:0005930	axoneme	INPP5E	IDA		Human	PMID:19668215
Cellular Component	GO:0005930	axoneme	Inpp5e	IDA		Mouse	MGI:MGI:4359555|PMID:19668215
Cellular Component	GO:0005929	cilium	Inpp5e	IDA		Mouse	PMID:28154160
Cellular Component	GO:0005737	cytoplasm	Inpp5e	IDA		Rat	PMID:10405344|RGD:1299274
Cellular Component	GO:0000139	Golgi membrane	Inpp5e	IDA		Mouse	PMID:10806194
Cellular Component	GO:0005634	nucleus	Inpp5e	IDA		Mouse	MGI:MGI:6099010|PMID:26051944
Cellular Component	GO:0005886	plasma membrane	Inpp5e	IDA		Rat	PMID:10405344|RGD:1299274
Cellular Component	GO:0001726	ruffle	Inpp5e	IDA		Rat	PMID:10405344|RGD:1299274
Biological Process	GO:0060271	cilium assembly	inpp5e	IMP	ZFIN:ZDB-MRPHLNO-130206-1	Zfish	PMID:23022135
Biological Process	GO:0035850	epithelial cell differentiation involved in kidney development	inpp5e	IMP	ZFIN:ZDB-GENO-170601-2	Zfish	PMID:27401686
Biological Process	GO:0032402	melanosome transport	inpp5e	IMP	ZFIN:ZDB-MRPHLNO-130206-1	Zfish	PMID:23022135
Biological Process	GO:0014067	negative regulation of phosphatidylinositol 3-kinase signaling	Inpp5e	IDA		Rat	PMID:21436142|RGD:12911213
Biological Process	GO:1903565	negative regulation of protein localization to cilium	Inpp5e	IMP		Mouse	PMID:28154160
Biological Process	GO:0017148	negative regulation of translation	Inpp5e	IDA		Rat	PMID:21436142|RGD:12911213
Biological Process	GO:0046856	phosphatidylinositol dephosphorylation	Inpp5e	IDA		Mouse	PMID:10806194
Biological Process	GO:0046488	phosphatidylinositol metabolic process	Inpp5e	IDA		Mouse	PMID:10806194
Biological Process	GO:0046488	phosphatidylinositol metabolic process	Inpp5e	IMP		Mouse	PMID:28154160
Biological Process	GO:1902017	regulation of cilium assembly	inpp5e	IMP	ZFIN:ZDB-GENO-170601-2	Zfish	PMID:27401686
Biological Process	GO:0060041	retina development in camera-type eye	inpp5e	IMP	ZFIN:ZDB-MRPHLNO-130206-1	Zfish	PMID:23022135

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern