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Inpp5e
Gene Detail
Symbol

Name
ID
Inpp5e
inositol polyphosphate-5-phosphatase E
MGI:1927753
Synonyms
1200002L24Rik, 72kDa, mKIAA0123
Feature Type
protein coding gene
Genetic Map
Chromosome 2
18.88 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:26396249-26409203 bp, - strand
From VEGA annotation of GRCm38

  12955 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56863  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Inpp5e

Human
homologs
Human Homolog INPP5E, inositol polyphosphate-5-phosphatase, 72 kDa
NCBI Gene ID 56623
neXtProt AC  NX_Q9NRR6
Human Synonyms  CORS1, CPD4, JBTS1, MORMS, PPI5PIV
Human Chr (Location)  9q34.3; chr9:136428615-136439853 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human INPP5E
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Chemically induced (ENU)(1) Gene trapped(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation display signs of ciliopathies including prenatal and perinatal lethality, polycystic kidneys, arrest of eye development, abnormalities in primary cilia, cerebral developmental defects, and skeletal defects.
 
Interactions
Inpp5e interacts with 187 markers (Mir15b, Mir16-1, Mir16-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process dephosphorylation, inositol phosphate dephosphorylation, ...
Component axoneme, cell projection, ...
Function hydrolase activity, inositol-polyphosphate 5-phosphatase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (101)    Tissues (99)    Images (10)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 97
Western blot 4
cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(15) cDNA(14) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000012777 (Evidence)
Ensembl Gene ModelENSMUSG00000026925 (Evidence)
Entrez Gene64436 (Evidence)
NIA Mouse Gene IndexU022423
EC3.1.3.36
Consensus CDS ProjectCCDS15805.1, CCDS71007.1
International Mouse Knockout Project StatusInpp5e
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012777 VEGA Gene Model | MGI Sequence Detail 12955 C57BL/6J ±  kb
transcript OTTMUST00000030592 VEGA | MGI Sequence Detail 4147 Not Applicable 
polypeptide OTTMUSP00000013735 VEGA | MGI Sequence Detail 647 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(5) UniProt(9)
Polymorphisms
SNPs within 2kb(63 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005135 Endonuclease/exonuclease/phosphatase
InterPro IPR000300 Inositol polyphosphate-related phosphatase
Protein Ontology PR:000009049 72 kDa inositol polyphosphate 5-phosphatase
References
(Earliest) J:63827 Kong AM, et al., Cloning and characterization of a 72-kDa inositol-polyphosphate 5-phosphatase localized to the Golgi network. J Biol Chem. 2000 Aug 4;275(31):24052-64
(Latest) J:186861 Sun M, et al., Multiplex Chromosomal Exome Sequencing Accelerates Identification of ENU-Induced Mutations in the Mouse. G3 (Bethesda). 2012 Jan;2(1):143-50
All references(34)
Other
accession IDs
MGI:1914115

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory