Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IL5
  • Mouse genes Il5
  • Rat genes Il5
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Il5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005125	cytokine activity	IL5	IDA		Human	PMID:33099778
Molecular Function	GO:0005125	cytokine activity	Il5	IDA		Mouse	PMID:10872802
Molecular Function	GO:0005125	cytokine activity	Il5	IDA		Rat	PMID:10331007|RGD:2303508
Molecular Function	GO:0005125	cytokine activity	Il5	IDA		Rat	PMID:10529595|RGD:2303750
Molecular Function	GO:0005125	cytokine activity	Il5	IDA		Rat	PMID:10727846|RGD:2303509
Molecular Function	GO:0005125	cytokine activity	Il5	IMP		Rat	PMID:10867506|RGD:2303751
Molecular Function	GO:0005125	cytokine activity	Il5	IMP		Rat	PMID:1653053|RGD:728921
Molecular Function	GO:0005137	interleukin-5 receptor binding	Il5	IDA		Rat	PMID:10331007|RGD:2303508
Molecular Function	GO:0005137	interleukin-5 receptor binding	Il5	IMP		Rat	PMID:10867506|RGD:2303751
Molecular Function	GO:0005515	protein binding	IL5	IPI	UniProtKB:P32927	Human	PMID:1495999
Molecular Function	GO:0005515	protein binding	IL5	IPI	UniProtKB:Q01344	Human	PMID:1495999
Molecular Function	GO:0005515	protein binding	IL5	IPI	UniProtKB:Q01344-2	Human	PMID:22153509
Cellular Component	GO:0005576	extracellular region	IL5	IDA		Human	PMID:20041150
Cellular Component	GO:0005615	extracellular space	IL5	IDA		Human	PMID:33099778
Cellular Component	GO:0005615	extracellular space	Il5	IDA		Mouse	PMID:16769892
Cellular Component	GO:0005615	extracellular space	Il5	IDA		Mouse	PMID:21460847
Cellular Component	GO:0005615	extracellular space	Il5	IDA		Mouse	PMID:15240714
Cellular Component	GO:0005615	extracellular space	Il5	IDA		Mouse	PMID:16275384
Cellular Component	GO:0005615	extracellular space	Il5	IDA		Mouse	PMID:18997793
Cellular Component	GO:0005615	extracellular space	Il5	IDA		Mouse	PMID:15087456
Cellular Component	GO:0005615	extracellular space	Il5	IDA		Mouse	PMID:11057672
Cellular Component	GO:0005615	extracellular space	Il5	IDA		Rat	PMID:20232121|RGD:5134997
Biological Process	GO:0019221	cytokine-mediated signaling pathway	Il5	IMP		Rat	PMID:10867506|RGD:2303751
Biological Process	GO:0019221	cytokine-mediated signaling pathway	Il5	IDA		Rat	PMID:11335106|RGD:2303510
Biological Process	GO:0006954	inflammatory response	Il5	IEP		Rat	PMID:11884473|RGD:625643
Biological Process	GO:0038043	interleukin-5-mediated signaling pathway	IL5	IDA		Human	PMID:33099778
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	Il5	IDA		Mouse	PMID:10872802
Biological Process	GO:0030890	positive regulation of B cell proliferation	Il5	IDA		Rat	PMID:10529595|RGD:2303750
Biological Process	GO:0008284	positive regulation of cell population proliferation	Il5	IDA		Rat	PMID:10331007|RGD:2303508
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	Il5	IDA		Mouse	MGI:MGI:74350|PMID:7749983
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Il5	IDA		Mouse	MGI:MGI:74350|PMID:7749983
Biological Process	GO:0045645	positive regulation of eosinophil differentiation	Il5	IDA		Rat	PMID:10529595|RGD:2303750
Biological Process	GO:0045645	positive regulation of eosinophil differentiation	Il5	IDA		Rat	PMID:10727846|RGD:2303509
Biological Process	GO:0002639	positive regulation of immunoglobulin production	Il5	IGI	UniProtKB:Q8BVZ5	Mouse	MGI:MGI:3775141|PMID:18268038
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	Il5	IDA		Mouse	PMID:10872802
Biological Process	GO:0071803	positive regulation of podosome assembly	IL5	IDA		Human	PMID:15220135
Biological Process	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	Il5	IMP		Rat	PMID:10867506|RGD:2303751

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern