About   Help   FAQ
Il5 Gene Detail
Summary
  • Symbol
    Il5
  • Name
    interleukin 5
  • Synonyms
    Il-5
  • Feature Type
    protein coding gene
  • IDs
    MGI:96557
    NCBI Gene: 16191
  • Gene Overview
    MyGene.info: IL5
Location & Maps
more
  • Sequence Map
    Chr11:53720794-53725106 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4313 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 31.99 cM, cytoband A5/B1
  • Mapping Data
    31 experiments
  • Sequence Tag
Homology
more
  • Human Ortholog
    IL5, interleukin 5
  • Vertebrate Orthologs
    7
  • Human Ortholog
    IL5, interleukin 5
    Orthology source: HGNC, HomoloGene
  • Synonyms
    EDF, IL-5, TRF
  • Links
    NCBI Gene ID: 3567
    neXtProt AC: NX_P05113

  • Chr Location
    5q31.1; chr5:132541444-132556890 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    39 phenotypes from 6 alleles in 7 genetic backgrounds
    14 phenotypes from multigenic genotypes
    127 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Chemically induced (other)
    1
  • Targeted
    7
  • Transgenic
    6
  • Genomic Mutations
    1 involving Il5
  • Incidental Mutations
Homozygotes for a targeted null mutation exhibit loss of normal airway hyperreactivity resulting from aeroallergen challenge, reduced numbers of CD5+ B cells in the peritoneal cavity at 2 weeks, and some altered responses to schistosomiasis infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005643 VEGA Gene Model | MGI Sequence Detail 4313 C57BL/6J ±  kb
transcript OTTMUST00000012554 VEGA | MGI Sequence Detail 1537 Not Applicable  
polypeptide OTTMUSP00000005818 VEGA | MGI Sequence Detail 133 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    57 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 35
    Genomic 11
    cDNA 15
    Primer pair 8
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-11356, MGD-MRK-11387
References
more
  • Summaries
    All 193
    Developmental Gene Expression 6
    Gene Ontology 15
    Phenotypes 127
  • Earliest
    J:8504 Kinashi T, et al., Cloning of complementary DNA encoding T-cell replacing factor and identity with B-cell growth factor II. Nature. 1986 Nov 6-12;324(6092):70-3
  • Latest
    J:220790 Van Gool F, et al., Interleukin-5-producing group 2 innate lymphoid cells control eosinophilia induced by interleukin-2 therapy. Blood. 2014 Dec 4;124(24):3572-6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/12/2016
MGI 6.04
The Jackson Laboratory