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Il5
Gene Detail
Symbol

Name
ID
Il5
interleukin 5
MGI:96557
STS
Synonyms
Il-5
Feature Type
protein coding gene
Genetic Map
Chromosome 11
31.99 cM, cytoband A5/B1
Detailed Genetic Map ± 1 cM


Mapping data(31)
Sequence Map
Chr11:53720794-53725106 bp, + strand
From VEGA annotation of GRCm38

  4313 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:679  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: IL5
Protein SuperFamily: interleukin-5
Gene Tree: Il5

Human
homologs
IL5, interleukin 5
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3567
neXtProt AC: NX_P05113

Human Synonyms: EDF, IL-5, TRF

Human Chr (Location): 5q31.1; chr5:132541444-132556890 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for a targeted null mutation exhibit loss of normal airway hyperreactivity resulting from aeroallergen challenge, reduced numbers of CD5+ B cells in the peritoneal cavity at 2 weeks, and some altered responses to schistosomiasis infection.
 
Interactions
Il5 interacts with 194 markers (Mir19a, Mir23a, Mir27a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process cytokine-mediated signaling pathway, immune response, ...
Component extracellular region, extracellular space
Function cytokine activity, growth factor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (37)    Tissues (20)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 32
Nuclease S1 5
cDNA source data(10)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(35) Genomic(11) cDNA(15) Primer pair(8) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000005643 (Evidence)
Ensembl Gene Model ENSMUSG00000036117 (Evidence)
Entrez Gene 16191 (Evidence)
UniGene 4461
DFCI TC1591053
DoTS DT.87048101
NIA Mouse Gene Index U012602
PDB 3B5K
Consensus CDS Project CCDS24685.1
International Mouse Phenotyping Consortium Status Il5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005643 VEGA Gene Model | MGI Sequence Detail 4313 C57BL/6J ±  kb
transcript OTTMUST00000012554 VEGA | MGI Sequence Detail 1537 Not Applicable 
polypeptide OTTMUSP00000005818 VEGA | MGI Sequence Detail 133 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(4) UniProt(3)
Polymorphisms
All PCR and RFLP(15) : PCR(12) RFLP(3) SNPs within 2kb(57 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012351 Four-helical cytokine, core
InterPro IPR009079 Four-helical cytokine-like, core
InterPro IPR000186 Interleukin-5
Protein Ontology PR:000001392 interleukin-5
References
(Earliest) J:8504 Kinashi T, et al., Cloning of complementary DNA encoding T-cell replacing factor and identity with B-cell growth factor II. Nature. 1986 Nov 6-12;324(6092):70-3
(Latest) J:220790 Van Gool F, et al., Interleukin-5-producing group 2 innate lymphoid cells control eosinophilia induced by interleukin-2 therapy. Blood. 2014 Dec 4;124(24):3572-6
All references(192)
Other
accession IDs
MGD-MRK-11356, MGD-MRK-11387

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory