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Il5
Gene Detail
 Symbol
Name
ID
Il5
interleukin 5
MGI:96557
STS D11Nds9
Synonyms Il-5
Feature Type protein coding gene
Genetic Map
Chromosome 11
31.99 cM, cytoband A5/B1
Detailed Genetic Map ± 1 cM


Mapping data(31)
Sequence Map
Chr11:53720794-53725106 bp, + strand
From VEGA annotation of GRCm38

  4313 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:679  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog

Protein SuperFamily: interleukin-5
Gene Tree: Il5

Human
homologs
Human Homolog IL5, interleukin 5
NCBI Gene ID 3567
neXtProt AC  NX_P05113
Human Synonyms  EDF, IL-5, TRF
Human Chr (Location)  5q31.1; chr5:132541444-132556863 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit loss of normal airway hyperreactivity resulting from aeroallergen challenge, reduced numbers of CD5+ B cells in the peritoneal cavity at 2 weeks, and some altered responses to schistosomiasis infection.
 
Interactions
Il5 interacts with 194 markers (Mir19a, Mir23a, Mir27a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process cytokine-mediated signaling pathway, immune response, ...
Component extracellular region, extracellular space
Function cytokine activity, growth factor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (37)    Tissues (20)    Images (1)
Theiler Stages: 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
RT-PCR 32
Nuclease S1 5
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(35) Genomic(11) cDNA(15) Primer pair(8) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000005643 (Evidence)
Ensembl Gene ModelENSMUSG00000036117 (Evidence)
Entrez Gene16191 (Evidence)
UniGene4461
DFCITC1591053
DoTSDT.87048101
NIA Mouse Gene IndexU012602
PDB3B5K
Consensus CDS ProjectCCDS24685.1
International Mouse Knockout Project StatusIl5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005643 VEGA Gene Model | MGI Sequence Detail 4313 C57BL/6J ±  kb
transcript OTTMUST00000012554 VEGA | MGI Sequence Detail 1537 Not Applicable 
polypeptide OTTMUSP00000005818 VEGA | MGI Sequence Detail 133 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(3)
Polymorphisms All PCR and RFLP(15) : PCR(12) RFLP(3) SNPs within 2kb(57 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012351 Four-helical cytokine, core
InterPro IPR009079 Four-helical cytokine-like, core
InterPro IPR000186 Interleukin-5
Protein Ontology PR:000001392 interleukin-5
References (Earliest) J:8504 Kinashi T, et al., Cloning of complementary DNA encoding T-cell replacing factor and identity with B-cell growth factor II. Nature. 1986 Nov 6-12;324(6092):70-3
(Latest) J:209984 Hara K, et al., Airway uric acid is a sensor of inhaled protease allergens and initiates type 2 immune responses in respiratory mucosa. J Immunol. 2014 May 1;192(9):4032-42
All references(193)
Other
accession IDs
MGD-MRK-11356, MGD-MRK-11387

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory