Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IL22
  • Mouse genes Il22
  • Rat genes Il22
  • Zfish genes il22
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Il22

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005125	cytokine activity	Il22	IDA		Mouse	PMID:28811323
Molecular Function	GO:0005515	protein binding	IL22	IPI	UniProtKB:Q08334	Human	PMID:12513909
Molecular Function	GO:0005515	protein binding	IL22	IPI	UniProtKB:Q8N6P7	Human	PMID:12513909
Molecular Function	GO:0005515	protein binding	IL22	IPI	UniProtKB:Q8N6P7	Human	PMID:18599299
Molecular Function	GO:0005515	protein binding	IL22	IPI	UniProtKB:Q8N6P7	Human	PMID:18675809
Molecular Function	GO:0005515	protein binding	IL22	IPI	UniProtKB:Q08334	Human	PMID:20462497
Molecular Function	GO:0005515	protein binding	IL22	IPI	UniProtKB:Q8N6P7	Human	PMID:20462497
Molecular Function	GO:0005515	protein binding	Il22	IPI	PR:Q80XF5	Mouse	PMID:12700595
Cellular Component	GO:0005615	extracellular space	Il22	IDA		Mouse	PMID:28811323
Cellular Component	GO:0005615	extracellular space	Il22	IDA		Rat	PMID:19664145|RGD:5147412
Biological Process	GO:0050829	defense response to Gram-negative bacterium	il22	IDA		Zfish	PMID:16005068
Biological Process	GO:0006955	immune response	il22	IDA		Zfish	PMID:16005068
Biological Process	GO:0050728	negative regulation of inflammatory response	Il22	IDA		Mouse	PMID:28811323
Biological Process	GO:0050728	negative regulation of inflammatory response	Il22	IMP	MGI:MGI:3761615	Mouse	PMID:23075849
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Il22	IGI	MGI:MGI:2676631	Mouse	PMID:16982811
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Il22	IGI	UniProtKB:Q16552	Mouse	PMID:16982811
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Il22	IDA		Mouse	PMID:16982811
Biological Process	GO:0072593	reactive oxygen species metabolic process	Il22	IDA		Mouse	PMID:12700595
Biological Process	GO:0050727	regulation of inflammatory response	il22	IMP	ZFIN:ZDB-MRPHLNO-131202-3	Zfish	PMID:23999050
Biological Process	GO:0042509	regulation of tyrosine phosphorylation of STAT protein	Il22	IDA		Mouse	PMID:12700595
Biological Process	GO:0051384	response to glucocorticoid	Il22	IEP		Rat	PMID:19664145|RGD:5147412

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern