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Il22 Gene Detail
Summary
  • Symbol
    Il22
  • Name
    interleukin 22
  • Synonyms
    IL-22, Iltif, IL-TIF
  • Feature Type
    protein coding gene
  • IDs
    MGI:1355307
    NCBI Gene: 50929
  • Gene Overview
    MyGene.info: IL22
Location & Maps
more
  • Sequence Map
    Chr10:118204942-118210047 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5106 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 66.67 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    IL22, interleukin 22
  • Vertebrate Orthologs
    10
  • Human Ortholog
    IL22, interleukin 22
    Orthology source: HGNC, HomoloGene
  • Synonyms
    IL-21, IL-22, IL-D110, ILTIF, IL-TIF, TIFa, TIFIL-23, zcyto18
  • Links
    NCBI Gene ID: 50616
    neXtProt AC: NX_Q9GZX6

  • Chr Location
    12q15; chr12:68248245-68253501 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    35 phenotypes from 5 alleles in 7 genetic backgrounds
    9 phenotypes from multigenic genotypes
    59 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Targeted
    6
  • Transgenic
    1
  • Genomic Mutations
    1 involving Il22
  • Incidental Mutations
Mutation of this locus results in abnormalities in Il23-induced dermal inflammation and acanthosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042450 VEGA Gene Model | MGI Sequence Detail 5106 C57BL/6J ±  kb
transcript OTTMUST00000111946 VEGA | MGI Sequence Detail 1110 Not Applicable  
polypeptide OTTMUSP00000062779 VEGA | MGI Sequence Detail 179 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    107 from dbSNP Build 142
  • PCR
Protein
Information
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  • UniProt
    2 Sequences
  • InterPro Domains
    IPR012351 Four-helical cytokine, core
    IPR009079 Four-helical cytokine-like, core
    IPR020443 Interleukin-10/19/20/22/24/26 family
    IPR020423 Interleukin-10, conserved site
    IPR020453 Interleukin-22
Molecular
Reagents
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  • All nucleic 4
    cDNA 3
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 90
    Developmental Gene Expression 1
    Gene Ontology 7
    Phenotypes 59
  • Earliest
    J:60655 Dumoutier L, et al., Cloning and characterization of IL-10-related T cell-derived inducible factor (IL-TIF), a novel cytokine structurally related to IL-10 and inducible by IL-9. J Immunol. 2000 Feb 15;164(4):1814-9
  • Latest
    J:233769 Lee JS, et al., Interleukin-23-Independent IL-17 Production Regulates Intestinal Epithelial Permeability. Immunity. 2015 Oct 20;43(4):727-38

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory