About   Help   FAQ
Il22 Gene Detail
Summary
  • Symbol
    Il22
  • Name
    interleukin 22
  • Synonyms
    IL-22, Iltif, IL-TIF
  • Feature Type
    protein coding gene
  • IDs
    MGI:1355307
    NCBI Gene: 50929
  • Gene Overview
    MyGene.info: IL22
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:118204942-118210047 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 66.67 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    107 from dbSNP Build 142
  • Strain Annotations
    6
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1355307
protein coding gene Chr10:118204584-118210047 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017766
protein coding gene Chr10:121213227-121220209 (+)
A/J no annotation
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ no annotation
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J no annotation
FVB/NJ MGP_FVBNJ_G0017599
protein coding gene Chr10:114534797-114539059 (+)
LP/J MGP_LPJ_G0017677
protein coding gene Chr10:121834068-121839689 (-)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0018200
protein coding gene Chr10:119904884-119910327 (+)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0016664
protein coding gene Chr10:118835493-118840850 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    IL22, interleukin 22
  • Vertebrate Orthologs
    10
  • Human Ortholog
    IL22, interleukin 22
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IL-21, IL-22, IL-D110, ILTIF, IL-TIF, TIFa, TIFIL-23, zcyto18
  • Links
    NCBI Gene ID: 50616
    neXtProt AC: NX_Q9GZX6
    UniProt: Q9GZX6

  • Chr Location
    12q15; chr12:68248245-68253501 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Il22 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    35 phenotypes from 5 alleles in 7 genetic backgrounds
    9 phenotypes from multigenic genotypes
    87 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mutation of this locus results in abnormalities in Il23-induced dermal inflammation and acanthosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000074695 Ensembl Gene Model | MGI Sequence Detail 5106 C57BL/6J ±  kb
    transcript ENSMUST00000096691 Ensembl | MGI Sequence Detail 1110 Not Applicable  
    polypeptide ENSMUSP00000094449 Ensembl | MGI Sequence Detail 179 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR009079 Four-helical cytokine-like, core
      IPR020423 Interleukin-10, conserved site
      IPR020453 Interleukin-22
    Molecular
    Reagents
    less
    • All nucleic 5
      cDNA 3
      Primer pair 2

      Microarray probesets 2
    References
    more
    • Summaries
      All 166
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 6
      Phenotypes 87
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:272902 Bai L, et al., STAT1 activation represses IL-22 gene expression and psoriasis pathogenesis. Biochem Biophys Res Commun. 2018 Jun 22;501(2):563-569

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    06/04/2019
    MGI 6.14
    The Jackson Laboratory