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Il22
Gene Detail
Symbol

Name
ID
Il22
interleukin 22
MGI:1355307
Synonyms
IL-22, Iltif, IL-TIF
Feature Type
protein coding gene
Genetic Map
Chromosome 10
66.67 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr10:118204942-118210047 bp, + strand
From VEGA annotation of GRCm38

  5106 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9669  Vertebrate Homology Class
1 human; 2 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: interleukin-22
Gene Tree: Il22

Human
homologs
Human Homolog IL22, interleukin 22
NCBI Gene ID 50616
neXtProt AC  NX_Q9GZX6
Human Synonyms  IL-21, IL-22, IL-D110, ILTIF, IL-TIF, TIFa, TIFIL-23, zcyto18
Human Chr (Location)  12q15; chr12:68248245-68253599 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mutation of this locus results in abnormalities in Il23-induced dermal inflammation and acanthosis.
 
Interactions
Il22 interacts with 76 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (1 records)
cDNA source data(3)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(4) cDNA(3) Primer pair(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000042450 (Evidence)
Ensembl Gene ModelENSMUSG00000074695 (Evidence)
Entrez Gene50929 (Evidence)
UniGene103585
DoTSDT.87048417
Consensus CDS ProjectCCDS36070.1
International Mouse Knockout Project StatusIl22
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042450 VEGA Gene Model | MGI Sequence Detail 5106 C57BL/6J ±  kb
transcript OTTMUST00000111946 VEGA | MGI Sequence Detail 1110 Not Applicable 
polypeptide OTTMUSP00000062779 VEGA | MGI Sequence Detail 179 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(4) UniProt(3)
Polymorphisms
PCR(1) : SNPs within 2kb(121 from dbSNP Build 137)    SNPs within 2kb including multiple locations(181)
Protein-related
information
ResourceIDDescription
InterPro IPR012351 Four-helical cytokine, core
InterPro IPR009079 Four-helical cytokine-like, core
InterPro IPR020443 Interleukin-10/19/20/24
InterPro IPR020423 Interleukin-10, conserved site
InterPro IPR020453 Interleukin-22
Protein Ontology PR:000001383 interleukin-22
References
(Earliest) J:60655 Dumoutier L, et al., Cloning and characterization of IL-10-related T cell-derived inducible factor (IL-TIF), a novel cytokine structurally related to IL-10 and inducible by IL-9. J Immunol. 2000 Feb 15;164(4):1814-9
(Latest) J:213686 Perera GK, et al., Integrative biology approach identifies cytokine targeting strategies for psoriasis. Sci Transl Med. 2014 Feb 12;6(223):223ra22
All references(81)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory