Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IL2
  • Mouse genes Il2
  • Rat genes Il2
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Il2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0030246	carbohydrate binding	Il2	IDA		Rat	PMID:6609839|RGD:1600093
Molecular Function	GO:0005125	cytokine activity	IL2	IDA		Human	PMID:10072077
Molecular Function	GO:0005125	cytokine activity	IL2	IDA		Human	PMID:1830926
Molecular Function	GO:0005125	cytokine activity	IL2	IDA		Human	PMID:21516110
Molecular Function	GO:0005125	cytokine activity	Il2	IDA		Mouse	PMID:10485657
Molecular Function	GO:0005125	cytokine activity	Il2	IMP		Mouse	PMID:12874832
Molecular Function	GO:0005125	cytokine activity	Il2	IDA		Mouse	PMID:23395675
Molecular Function	GO:0005125	cytokine activity	Il2	IDA		Mouse	PMID:1588041
Molecular Function	GO:0005125	cytokine activity	Il2	IDA		Rat	PMID:6979751|RGD:2303493
Molecular Function	GO:0043208	glycosphingolipid binding	Il2	IDA		Rat	PMID:6609839|RGD:1600093
Molecular Function	GO:0005134	interleukin-2 receptor binding	IL2	IDA		Human	PMID:8262055
Molecular Function	GO:0005134	interleukin-2 receptor binding	Il2	IDA		Mouse	PMID:1588041
Molecular Function	GO:0005134	interleukin-2 receptor binding	Il2	IDA		Mouse	PMID:7584142
Molecular Function	GO:0005134	interleukin-2 receptor binding	Il2	IDA		Mouse	PMID:8262055
Molecular Function	GO:0005134	interleukin-2 receptor binding	Il2	IMP		Rat	PMID:3124825|RGD:1600106
Molecular Function	GO:0031851	kappa-type opioid receptor binding	Il2	IMP		Rat	PMID:11907831|RGD:727354
Molecular Function	GO:0005515	protein binding	IL2	IPI	UniProtKB:P01589	Human	PMID:16477002
Molecular Function	GO:0005515	protein binding	IL2	IPI	UniProtKB:P14784	Human	PMID:16477002
Molecular Function	GO:0005515	protein binding	IL2	IPI	UniProtKB:P01589	Human	PMID:17032757
Molecular Function	GO:0005515	protein binding	IL2	IPI	UniProtKB:P14784	Human	PMID:22446627
Cellular Component	GO:0005615	extracellular space	IL2	IDA		Human	PMID:18273057
Cellular Component	GO:0005615	extracellular space	Il2	IDA		Mouse	PMID:23395675
Cellular Component	GO:0005615	extracellular space	Il2	IDA		Mouse	PMID:12874832
Cellular Component	GO:0005615	extracellular space	Il2	IDA		Mouse	PMID:16769892
Cellular Component	GO:0005615	extracellular space	Il2	IDA		Mouse	PMID:11728336
Cellular Component	GO:0005615	extracellular space	Il2	IDA		Mouse	PMID:8612131
Cellular Component	GO:0005615	extracellular space	Il2	IDA		Mouse	PMID:10072077
Cellular Component	GO:0005615	extracellular space	Il2	IDA		Mouse	PMID:1830926
Cellular Component	GO:0005615	extracellular space	Il2	IDA		Mouse	PMID:9492004
Cellular Component	GO:0005615	extracellular space	Il2	IDA		Mouse	PMID:7688139
Cellular Component	GO:0005615	extracellular space	Il2	IDA		Mouse	PMID:15087456
Cellular Component	GO:0005615	extracellular space	Il2	IDA		Mouse	PMID:19139201
Cellular Component	GO:0005615	extracellular space	Il2	IDA		Rat	PMID:8186377|RGD:1600098
Biological Process	GO:0050798	activated T cell proliferation	Il2	IDA		Mouse	PMID:7584142
Biological Process	GO:0050798	activated T cell proliferation	Il2	IMP	MGI:MGI:1857191	Mouse	PMID:1830926
Biological Process	GO:0050798	activated T cell proliferation	Il2	IDA		Mouse	PMID:10485657
Biological Process	GO:0071216	cellular response to biotic stimulus	Il2	IDA		Mouse	PMID:23262141
Biological Process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	Il2	IDA		Mouse	PMID:12082633
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	Il2	IMP		Rat	PMID:11907831|RGD:727354
Biological Process	GO:0010467	gene expression	Il2	IDA		Mouse	PMID:28396406
Biological Process	GO:0038110	interleukin-2-mediated signaling pathway	IL2	IDA		Human	PMID:22844114
Biological Process	GO:0002366	leukocyte activation involved in immune response	IL2	IDA		Human	PMID:16204630
Biological Process	GO:0046651	lymphocyte proliferation	Il2	IMP	MGI:MGI:1857191	Mouse	PMID:16227984
Biological Process	GO:0002903	negative regulation of B cell apoptotic process	IL2	IDA		Human	PMID:9184696
Biological Process	GO:0045822	negative regulation of heart contraction	Il2	IDA		Rat	PMID:11907831|RGD:727354
Biological Process	GO:0050728	negative regulation of inflammatory response	Il2	IMP	MGI:MGI:1857191	Mouse	PMID:8402910
Biological Process	GO:0050728	negative regulation of inflammatory response	Il2	IMP	MGI:MGI:1857191	Mouse	PMID:7589135
Biological Process	GO:0050672	negative regulation of lymphocyte proliferation	Il2	IMP	MGI:MGI:1857191	Mouse	PMID:16227984
Biological Process	GO:0001933	negative regulation of protein phosphorylation	Il2	IDA		Rat	PMID:3124825|RGD:1600106
Biological Process	GO:2000320	negative regulation of T-helper 17 cell differentiation	Il2	IGI	RNAcentral:URS000039ED8D_10090	Mouse	MGI:MGI:5634593|PMID:25642768
Biological Process	GO:0042104	positive regulation of activated T cell proliferation	IL2	IDA		Human	PMID:10072077
Biological Process	GO:0042104	positive regulation of activated T cell proliferation	IL2	IDA		Human	PMID:1830926
Biological Process	GO:0042104	positive regulation of activated T cell proliferation	Il2	IDA		Mouse	PMID:10485657
Biological Process	GO:0042104	positive regulation of activated T cell proliferation	Il2	IDA		Mouse	PMID:7584142
Biological Process	GO:0042104	positive regulation of activated T cell proliferation	Il2	IMP	MGI:MGI:1857191	Mouse	PMID:1830926
Biological Process	GO:0030890	positive regulation of B cell proliferation	IL2	IDA		Human	PMID:9184696
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	Il2	IDA		Rat	PMID:11907831|RGD:727354
Biological Process	GO:0060999	positive regulation of dendritic spine development	Il2	IDA		Rat	PMID:20225203|RGD:5147914
Biological Process	GO:0002639	positive regulation of immunoglobulin production	IL2	IGI	UniProtKB:P22301	Human	PMID:22962438
Biological Process	GO:0002639	positive regulation of immunoglobulin production	Il2	IMP	MGI:MGI:1857191	Mouse	PMID:1830926
Biological Process	GO:0032740	positive regulation of interleukin-17 production	IL2	IDA		Human	PMID:16482511
Biological Process	GO:0048304	positive regulation of isotype switching to IgG isotypes	Il2	IMP	MGI:MGI:1857191	Mouse	PMID:1830926
Biological Process	GO:1900100	positive regulation of plasma cell differentiation	IL2	IGI	UniProtKB:P22301	Human	PMID:22962438
Biological Process	GO:0001934	positive regulation of protein phosphorylation	Il2	IDA		Rat	PMID:3124825|RGD:1600106
Biological Process	GO:0045591	positive regulation of regulatory T cell differentiation	Il2	IDA		Rat	PMID:6233372|RGD:1600097
Biological Process	GO:0045582	positive regulation of T cell differentiation	Il2	IDA		Rat	PMID:9352365|RGD:1600138
Biological Process	GO:0042102	positive regulation of T cell proliferation	Il2	IMP	MGI:MGI:1857191	Mouse	PMID:22968459
Biological Process	GO:0042102	positive regulation of T cell proliferation	Il2	IDA		Mouse	PMID:1588041
Biological Process	GO:0042102	positive regulation of T cell proliferation	Il2	IDA		Rat	PMID:6609839|RGD:1600093
Biological Process	GO:0042102	positive regulation of T cell proliferation	Il2	IDA		Rat	PMID:6609879|RGD:2303494
Biological Process	GO:0042102	positive regulation of T cell proliferation	Il2	IDA		Rat	PMID:6979751|RGD:2303493
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Il2	IDA		Mouse	PMID:10485657
Biological Process	GO:0032729	positive regulation of type II interferon production	Il2	IDA		Mouse	PMID:17213291
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	IL2	IDA		Human	PMID:19088061
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	Il2	IDA		Mouse	PMID:10485657
Biological Process	GO:0007205	protein kinase C-activating G protein-coupled receptor signaling pathway	Il2	IMP		Rat	PMID:7859920|RGD:1600108
Biological Process	GO:2000561	regulation of CD4-positive, alpha-beta T cell proliferation	Il2	IMP	MGI:MGI:1857191	Mouse	PMID:16227984
Biological Process	GO:0046013	regulation of T cell homeostatic proliferation	Il2	IMP	MGI:MGI:1857191	Mouse	PMID:16227984
Biological Process	GO:0045471	response to ethanol	Il2	IDA		Rat	PMID:8045674|RGD:10047057
Biological Process	GO:0042098	T cell proliferation	Il2	IDA		Mouse	PMID:1588041
Biological Process	GO:0006366	transcription by RNA polymerase II	Il2	IDA		Mouse	PMID:10485657
Biological Process	GO:0007260	tyrosine phosphorylation of STAT protein	Il2	IDA		Mouse	PMID:10485657

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern