Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IL1RN
  • Mouse genes Il1rn
  • Rat genes Il1rn
  • Zfish genes il1fma
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Il1rn

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005152	interleukin-1 receptor antagonist activity	IL1RN	IDA		Human	PMID:2139180
Molecular Function	GO:0005149	interleukin-1 receptor binding	Il1rn	IDA		Rat	PMID:1834644|RGD:7174697
Molecular Function	GO:0045352	interleukin-1 type I receptor antagonist activity	IL1RN	IDA		Human	PMID:1828071
Molecular Function	GO:0045353	interleukin-1 type II receptor antagonist activity	IL1RN	IDA		Human	PMID:1830582
Molecular Function	GO:0005150	interleukin-1, type I receptor binding	IL1RN	IPI	UniProtKB:P13504	Human	PMID:1828071
Molecular Function	GO:0005151	interleukin-1, type II receptor binding	IL1RN	IPI	UniProtKB:P27930	Human	PMID:1830582
Molecular Function	GO:0005515	protein binding	IL1RN	IPI	UniProtKB:Q9NYB0	Human	PMID:21044950
Cellular Component	GO:0070062	extracellular exosome	IL1RN	HDA		Human	PMID:19056867
Cellular Component	GO:0005576	extracellular region	Il1rn	IDA		Mouse	PMID:15240711
Cellular Component	GO:0005615	extracellular space	IL1RN	IDA		Human	PMID:10443688
Cellular Component	GO:0005615	extracellular space	IL1RN	IDA		Human	PMID:12483741
Cellular Component	GO:0005615	extracellular space	Il1rn	IDA		Rat	PMID:17138728|RGD:1626670
Cellular Component	GO:0031982	vesicle	Il1rn	IDA		Mouse	PMID:15240711
Biological Process	GO:0019752	carboxylic acid metabolic process	Il1rn	IEP		Rat	PMID:9685640|RGD:7174732
Biological Process	GO:0071874	cellular response to norepinephrine stimulus	Il1rn	IEP		Rat	PMID:19818755|RGD:8551853
Biological Process	GO:0002439	chronic inflammatory response to antigenic stimulus	Il1rn	IEP		Rat	PMID:15050649|RGD:1626679
Biological Process	GO:0007565	female pregnancy	Il1rn	IEP		Rat	PMID:14603373|RGD:1626683
Biological Process	GO:0001660	fever generation	Il1rn	IMP		Rat	PMID:16455768|RGD:1626671
Biological Process	GO:0030073	insulin secretion	Il1rn	IMP	MGI:MGI:2157397	Mouse	PMID:12975454
Biological Process	GO:0006629	lipid metabolic process	Il1rn	IMP	MGI:MGI:2157397	Mouse	PMID:12975454
Biological Process	GO:0007613	memory	Il1rn	IMP		Rat	PMID:15050649|RGD:1626679
Biological Process	GO:0043066	negative regulation of apoptotic process	Il1rn	IMP		Rat	PMID:16038625|RGD:1626673
Biological Process	GO:0030336	negative regulation of cell migration	Il1rn	IDA		Rat	PMID:21244430|RGD:7174692
Biological Process	GO:0014050	negative regulation of glutamate secretion	Il1rn	IMP		Rat	PMID:12667655|RGD:1626684
Biological Process	GO:0034115	negative regulation of heterotypic cell-cell adhesion	IL1RN	IDA		Human	PMID:2139180
Biological Process	GO:2000660	negative regulation of interleukin-1-mediated signaling pathway	IL1RN	IDA		Human	PMID:2137200
Biological Process	GO:2000660	negative regulation of interleukin-1-mediated signaling pathway	IL1RN	IDA		Human	PMID:2139180
Biological Process	GO:0045837	negative regulation of membrane potential	Il1rn	IDA		Rat	PMID:20554014|RGD:7175067
Biological Process	GO:0043507	positive regulation of JUN kinase activity	Il1rn	IMP		Rat	PMID:12667655|RGD:1626684
Biological Process	GO:0014823	response to activity	Il1rn	IEP		Rat	PMID:22117073|RGD:7242191
Biological Process	GO:0051384	response to glucocorticoid	IL1RN	IDA		Human	PMID:10443688
Biological Process	GO:0070555	response to interleukin-1	Il1rn	IEP		Rat	PMID:8906613|RGD:8551743
Biological Process	GO:0070670	response to interleukin-4	Il1rn	IEP		Rat	PMID:8409406|RGD:7174710
Biological Process	GO:0032496	response to lipopolysaccharide	Il1rn	IEP		Rat	PMID:17138728|RGD:1626670
Biological Process	GO:0032496	response to lipopolysaccharide	Il1rn	IEP		Rat	PMID:23055766|RGD:6909174
Biological Process	GO:0014070	response to organic cyclic compound	Il1rn	IEP		Rat	PMID:15751073|RGD:1626675
Biological Process	GO:0010243	response to organonitrogen compound	Il1rn	IEP		Rat	PMID:17375077|RGD:1626669
Biological Process	GO:0042594	response to starvation	Il1rn	IEP		Rat	PMID:22117073|RGD:7242191
Biological Process	GO:0009410	response to xenobiotic stimulus	Il1rn	IEP		Rat	PMID:15837124|RGD:1626674
Biological Process	GO:0019233	sensory perception of pain	Il1rn	IMP		Rat	PMID:10903985|RGD:8549800

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern