Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IL1R2
  • Mouse genes Il1r2
  • Rat genes Il1r2
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Il1r2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019966	interleukin-1 binding	Il1r2	IPI	PR:000045525	Mouse	PMID:23395675
Molecular Function	GO:0004908	interleukin-1 receptor activity	Il1r2	IPI	PR:000045525	Mouse	PMID:23395675
Molecular Function	GO:0005515	protein binding	IL1R2	IPI	UniProtKB:P01583	Human	PMID:16971486
Molecular Function	GO:0005515	protein binding	IL1R2	IPI	UniProtKB:P18510	Human	PMID:1830582
Molecular Function	GO:0005515	protein binding	IL1R2	IPI	UniProtKB:P01583	Human	PMID:25241761
Cellular Component	GO:0005737	cytoplasm	Il1r2	IDA		Mouse	PMID:23395675
Biological Process	GO:1900016	negative regulation of cytokine production involved in inflammatory response	Il1r2	IMP		Mouse	PMID:23395675
Biological Process	GO:0032690	negative regulation of interleukin-1 alpha production	Il1r2	IMP		Mouse	PMID:23395675
Biological Process	GO:2000660	negative regulation of interleukin-1-mediated signaling pathway	Il1r2	IPI	PR:000045525	Mouse	PMID:23395675
Biological Process	GO:0010955	negative regulation of protein processing	Il1r2	IMP		Mouse	PMID:23395675
Biological Process	GO:0016485	protein processing	Il1r2	IMP		Mouse	PMID:23395675

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern