Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IL17F
  • Mouse genes Il17f
  • Rat genes Il17f
  • Zfish genes il17a/f1,il17a/f3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Il17f

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005125	cytokine activity	IL17F	IDA		Human	PMID:11591732
Molecular Function	GO:0019955	cytokine binding	IL17F	IDA		Human	PMID:11574464
Molecular Function	GO:0005126	cytokine receptor binding	Il17f	IPI	PR:Q8K4C2	Mouse	PMID:17911633
Molecular Function	GO:0005515	protein binding	IL17F	IPI	UniProtKB:Q53SE7	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	IL17F	IPI	UniProtKB:Q16552	Human	PMID:28827714
Molecular Function	GO:0005515	protein binding	IL17F	IPI	UniProtKB:Q8NAC3	Human	PMID:28827714
Molecular Function	GO:0005515	protein binding	IL17F	IPI	UniProtKB:Q96F46	Human	PMID:28827714
Molecular Function	GO:0005515	protein binding	Il17f	IPI	UniProtKB:Q62386	Mouse	MGI:MGI:4412246|PMID:18025225
Molecular Function	GO:0046982	protein heterodimerization activity	Il17f	IDA		Mouse	MGI:MGI:4412246|PMID:18025225
Molecular Function	GO:0042803	protein homodimerization activity	IL17F	IDA		Human	PMID:11574464
Molecular Function	GO:0042803	protein homodimerization activity	Il17f	IDA		Mouse	MGI:MGI:4412246|PMID:18025225
Cellular Component	GO:0005615	extracellular space	Il17f	IDA		Mouse	MGI:MGI:4412246|PMID:18025225
Cellular Component	GO:0005615	extracellular space	Il17f	IDA		Mouse	PMID:17982105
Biological Process	GO:0051216	cartilage development	IL17F	IDA		Human	PMID:11574464
Biological Process	GO:0071222	cellular response to lipopolysaccharide	il17a/f3	IDA		Zfish	PMID:16677828
Biological Process	GO:0050829	defense response to Gram-negative bacterium	Il17f	IMP		Mouse	MGI:MGI:3828868|PMID:19144317
Biological Process	GO:0050830	defense response to Gram-positive bacterium	Il17f	IMP		Mouse	MGI:MGI:3828868|PMID:19144317
Biological Process	GO:0097400	interleukin-17-mediated signaling pathway	IL17F	IDA		Human	PMID:21350122
Biological Process	GO:0016525	negative regulation of angiogenesis	IL17F	IDA		Human	PMID:11591732
Biological Process	GO:0002225	positive regulation of antimicrobial peptide production	Il17f	IDA		Mouse	MGI:MGI:3828868|PMID:19144317
Biological Process	GO:2000340	positive regulation of chemokine (C-X-C motif) ligand 1 production	IL17F	IDA		Human	PMID:21350122
Biological Process	GO:0001819	positive regulation of cytokine production	IL17F	IDA		Human	PMID:11591732
Biological Process	GO:1900017	positive regulation of cytokine production involved in inflammatory response	Il17f	IDA		Mouse	PMID:17982105
Biological Process	GO:1900017	positive regulation of cytokine production involved in inflammatory response	Il17f	IDA		Mouse	PMID:16785495
Biological Process	GO:1900017	positive regulation of cytokine production involved in inflammatory response	Il17f	IGI	MGI:MGI:107399	Mouse	PMID:16785495
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IL17F	IDA		Human	PMID:21350122
Biological Process	GO:0032755	positive regulation of interleukin-6 production	Il17f	IMP		Mouse	MGI:MGI:4462077|PMID:20554964
Biological Process	GO:0032761	positive regulation of lymphotoxin A production	IL17F	IDA		Human	PMID:11591732
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Il17f	IGI	MGI:MGI:1355307	Mouse	PMID:16982811
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Il17f	IDA		Mouse	PMID:16982811
Biological Process	GO:0032645	regulation of granulocyte macrophage colony-stimulating factor production	IL17F	IDA		Human	PMID:11574464
Biological Process	GO:0032663	regulation of interleukin-2 production	IL17F	IDA		Human	PMID:11591732
Biological Process	GO:0032675	regulation of interleukin-6 production	IL17F	IDA		Human	PMID:11574464
Biological Process	GO:0032677	regulation of interleukin-8 production	IL17F	IDA		Human	PMID:11574464
Biological Process	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	IL17F	IDA		Human	PMID:11591732

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern